We Are One: Multispecies Metabolism of a Biofilm Consortium and Their Treatment Strategies
The ecological and medical significance of bacterial biofilms have been well recognized. Biofilms are harder to control than their planktonic free-living counterparts and quite recently, the focus of the study has shifted to the multispecies consortia, which represent the vast majority of real-case...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2021.635432/full |
| _version_ | 1818648380019048448 |
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| author | Ruchika Vinod Joshi Cindy Gunawan Cindy Gunawan Riti Mann |
| author_facet | Ruchika Vinod Joshi Cindy Gunawan Cindy Gunawan Riti Mann |
| author_sort | Ruchika Vinod Joshi |
| collection | DOAJ |
| description | The ecological and medical significance of bacterial biofilms have been well recognized. Biofilms are harder to control than their planktonic free-living counterparts and quite recently, the focus of the study has shifted to the multispecies consortia, which represent the vast majority of real-case infection scenarios. Studies have begun to explore the complex interspecies interactions within these biofilms. However, only little attention is currently given to the role of cellular metabolites in the cell-to-cell communication. The concentration gradients of metabolic substrates and products affect the spatial growth of bacteria in multispecies biofilm. This, if looked into more deeply, can lead to identification of potential therapies targeting the specific metabolites and hence the coordinated protection in the bacterial community. Herein, we review the interspecies communications, including their metabolic cross-talking, in multispecies biofilm, to signify the importance of such interactions on the initial formation and subsequent growth of these biofilms. Multispecies biofilms with their species heterogeneity are more resilient to antimicrobial agents than their single species biofilm counterparts and this characteristic is of particular interest when dealing with pathogenic bacteria. In this Review, we also discuss the treatment options available, to include current and emerging avenues to combat pathogenic multispecies biofilms in the clinical, environmental, as well as industrial settings. |
| first_indexed | 2024-12-17T01:17:30Z |
| format | Article |
| id | doaj.art-7e250b87f5444841a11ee9d3aa13bd19 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-17T01:17:30Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-7e250b87f5444841a11ee9d3aa13bd192022-12-21T22:08:56ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-01-011210.3389/fmicb.2021.635432635432We Are One: Multispecies Metabolism of a Biofilm Consortium and Their Treatment StrategiesRuchika Vinod Joshi0Cindy Gunawan1Cindy Gunawan2Riti Mann3iThree Institute, University of Technology Sydney, Sydney, NSW, AustraliaiThree Institute, University of Technology Sydney, Sydney, NSW, AustraliaSchool of Chemical Engineering, University of New South Wales, Sydney, NSW, AustraliaiThree Institute, University of Technology Sydney, Sydney, NSW, AustraliaThe ecological and medical significance of bacterial biofilms have been well recognized. Biofilms are harder to control than their planktonic free-living counterparts and quite recently, the focus of the study has shifted to the multispecies consortia, which represent the vast majority of real-case infection scenarios. Studies have begun to explore the complex interspecies interactions within these biofilms. However, only little attention is currently given to the role of cellular metabolites in the cell-to-cell communication. The concentration gradients of metabolic substrates and products affect the spatial growth of bacteria in multispecies biofilm. This, if looked into more deeply, can lead to identification of potential therapies targeting the specific metabolites and hence the coordinated protection in the bacterial community. Herein, we review the interspecies communications, including their metabolic cross-talking, in multispecies biofilm, to signify the importance of such interactions on the initial formation and subsequent growth of these biofilms. Multispecies biofilms with their species heterogeneity are more resilient to antimicrobial agents than their single species biofilm counterparts and this characteristic is of particular interest when dealing with pathogenic bacteria. In this Review, we also discuss the treatment options available, to include current and emerging avenues to combat pathogenic multispecies biofilms in the clinical, environmental, as well as industrial settings.https://www.frontiersin.org/articles/10.3389/fmicb.2021.635432/fullbiofilmsmultispeciesmetabolismtreatmentinteractions |
| spellingShingle | Ruchika Vinod Joshi Cindy Gunawan Cindy Gunawan Riti Mann We Are One: Multispecies Metabolism of a Biofilm Consortium and Their Treatment Strategies Frontiers in Microbiology biofilms multispecies metabolism treatment interactions |
| title | We Are One: Multispecies Metabolism of a Biofilm Consortium and Their Treatment Strategies |
| title_full | We Are One: Multispecies Metabolism of a Biofilm Consortium and Their Treatment Strategies |
| title_fullStr | We Are One: Multispecies Metabolism of a Biofilm Consortium and Their Treatment Strategies |
| title_full_unstemmed | We Are One: Multispecies Metabolism of a Biofilm Consortium and Their Treatment Strategies |
| title_short | We Are One: Multispecies Metabolism of a Biofilm Consortium and Their Treatment Strategies |
| title_sort | we are one multispecies metabolism of a biofilm consortium and their treatment strategies |
| topic | biofilms multispecies metabolism treatment interactions |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2021.635432/full |
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