Elevated plasma total cholesterol level is associated with the risk of asymptomatic intracranial arterial stenosis.
BACKGROUND: Intracranial arterial stenosis (ICAS) is one of the most common causes of stroke, and dyslipidemia was one of the most common risk factors related to ICAS. However, the correlation between the plasma total cholesterol level (PTC) and ICAS, especially asymptomatic ICAS (AICAS) is not clea...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4081648?pdf=render |
| _version_ | 1819020130523283456 |
|---|---|
| author | Yuan Shen Jing Wang Jianwei Wu Weikai Qu Chunxue Wang Xiang Gao Yong Zhou Anxin Wang Shouling Wu Xingquan Zhao |
| author_facet | Yuan Shen Jing Wang Jianwei Wu Weikai Qu Chunxue Wang Xiang Gao Yong Zhou Anxin Wang Shouling Wu Xingquan Zhao |
| author_sort | Yuan Shen |
| collection | DOAJ |
| description | BACKGROUND: Intracranial arterial stenosis (ICAS) is one of the most common causes of stroke, and dyslipidemia was one of the most common risk factors related to ICAS. However, the correlation between the plasma total cholesterol level (PTC) and ICAS, especially asymptomatic ICAS (AICAS) is not clear. MATERIALS AND METHODS: 5,300 participants were enrolled in this study. The diagnosis of AICAS was made by transcranial Doppler ultrasonography. The participants were then divided into 5 essentially equal-sized groups based on their PTC levels. The multivariate logistic regression was used to analyze the correlation between the PTC level and the prevalence of AICAS. RESULTS: 13.0% of the participants were diagnosed with AICAS. The prevalence of AICAS gradually increased with the increasing PTC level. After adjusted by the possible confounding factors, the Odds Ratios (OR) of the AICAS prevalence between the 1st quintile group and the other 4 groups were 1.13, 1.23, 1.63 and 1.75 with 95% confident intervals (CI) of 0.84-1.52, 0.91-1.66, 1.20-2.22 and 1.23-2.47, respectively. The further subgroup analysis revealed that the PTC level was stronger for males (OR 1.42 95%CI 1.23-1.64), regarding the prevalence of AICAS. CONCLUSIONS: In this large community-based study, the prevalence of AICAS is 13.0%, subjects with higher PTC levels showed a mild increase in the prevalence of AICAS. The PTC level is an independent risk factor of AICAS. Males seem to be significantly more vulnerable to the risk of AICAS. |
| first_indexed | 2024-12-21T03:46:19Z |
| format | Article |
| id | doaj.art-7e25315ff6824235bb35280ac23eec6d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T03:46:19Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7e25315ff6824235bb35280ac23eec6d2022-12-21T19:17:04ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0197e10123210.1371/journal.pone.0101232Elevated plasma total cholesterol level is associated with the risk of asymptomatic intracranial arterial stenosis.Yuan ShenJing WangJianwei WuWeikai QuChunxue WangXiang GaoYong ZhouAnxin WangShouling WuXingquan ZhaoBACKGROUND: Intracranial arterial stenosis (ICAS) is one of the most common causes of stroke, and dyslipidemia was one of the most common risk factors related to ICAS. However, the correlation between the plasma total cholesterol level (PTC) and ICAS, especially asymptomatic ICAS (AICAS) is not clear. MATERIALS AND METHODS: 5,300 participants were enrolled in this study. The diagnosis of AICAS was made by transcranial Doppler ultrasonography. The participants were then divided into 5 essentially equal-sized groups based on their PTC levels. The multivariate logistic regression was used to analyze the correlation between the PTC level and the prevalence of AICAS. RESULTS: 13.0% of the participants were diagnosed with AICAS. The prevalence of AICAS gradually increased with the increasing PTC level. After adjusted by the possible confounding factors, the Odds Ratios (OR) of the AICAS prevalence between the 1st quintile group and the other 4 groups were 1.13, 1.23, 1.63 and 1.75 with 95% confident intervals (CI) of 0.84-1.52, 0.91-1.66, 1.20-2.22 and 1.23-2.47, respectively. The further subgroup analysis revealed that the PTC level was stronger for males (OR 1.42 95%CI 1.23-1.64), regarding the prevalence of AICAS. CONCLUSIONS: In this large community-based study, the prevalence of AICAS is 13.0%, subjects with higher PTC levels showed a mild increase in the prevalence of AICAS. The PTC level is an independent risk factor of AICAS. Males seem to be significantly more vulnerable to the risk of AICAS.http://europepmc.org/articles/PMC4081648?pdf=render |
| spellingShingle | Yuan Shen Jing Wang Jianwei Wu Weikai Qu Chunxue Wang Xiang Gao Yong Zhou Anxin Wang Shouling Wu Xingquan Zhao Elevated plasma total cholesterol level is associated with the risk of asymptomatic intracranial arterial stenosis. PLoS ONE |
| title | Elevated plasma total cholesterol level is associated with the risk of asymptomatic intracranial arterial stenosis. |
| title_full | Elevated plasma total cholesterol level is associated with the risk of asymptomatic intracranial arterial stenosis. |
| title_fullStr | Elevated plasma total cholesterol level is associated with the risk of asymptomatic intracranial arterial stenosis. |
| title_full_unstemmed | Elevated plasma total cholesterol level is associated with the risk of asymptomatic intracranial arterial stenosis. |
| title_short | Elevated plasma total cholesterol level is associated with the risk of asymptomatic intracranial arterial stenosis. |
| title_sort | elevated plasma total cholesterol level is associated with the risk of asymptomatic intracranial arterial stenosis |
| url | http://europepmc.org/articles/PMC4081648?pdf=render |
| work_keys_str_mv | AT yuanshen elevatedplasmatotalcholesterollevelisassociatedwiththeriskofasymptomaticintracranialarterialstenosis AT jingwang elevatedplasmatotalcholesterollevelisassociatedwiththeriskofasymptomaticintracranialarterialstenosis AT jianweiwu elevatedplasmatotalcholesterollevelisassociatedwiththeriskofasymptomaticintracranialarterialstenosis AT weikaiqu elevatedplasmatotalcholesterollevelisassociatedwiththeriskofasymptomaticintracranialarterialstenosis AT chunxuewang elevatedplasmatotalcholesterollevelisassociatedwiththeriskofasymptomaticintracranialarterialstenosis AT xianggao elevatedplasmatotalcholesterollevelisassociatedwiththeriskofasymptomaticintracranialarterialstenosis AT yongzhou elevatedplasmatotalcholesterollevelisassociatedwiththeriskofasymptomaticintracranialarterialstenosis AT anxinwang elevatedplasmatotalcholesterollevelisassociatedwiththeriskofasymptomaticintracranialarterialstenosis AT shoulingwu elevatedplasmatotalcholesterollevelisassociatedwiththeriskofasymptomaticintracranialarterialstenosis AT xingquanzhao elevatedplasmatotalcholesterollevelisassociatedwiththeriskofasymptomaticintracranialarterialstenosis |