Ablation of epidermal RXRα in cooperation with activated CDK4 and oncogenic NRAS generates spontaneous and acute neonatal UVB induced malignant metastatic melanomas

Ablation of epidermal RXRα in cooperation with activated CDK4 and oncogenic NRAS generates spontaneous and acute neonatal UVB induced malignant metastatic melanomas

Abstract Background Understanding the underlying molecular mechanisms involved in the formation of cutaneous malignant melanoma is critical for improved diagnosis and treatment. Keratinocytic nuclear receptor Retinoid X Receptor α (RXRα) has a protective role against melanomagenesis and is involved...

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Bibliographic Details
Main Authors: Sharmeen Chagani, Rong Wang, Evan L. Carpenter, Christiane V. Löhr, Gitali Ganguli-Indra, Arup K. Indra
Format: Article
Language:English
Published: BMC 2017-11-01
Series:BMC Cancer
Subjects:
Keratinocytes
Melanocytes
Acute UVB
Retinoid-X-receptor α (RXRα)
Malignant melanoma
Trigenic
Online Access:http://link.springer.com/article/10.1186/s12885-017-3714-6

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