Impact of dietary fiber on gut microbiota composition, function and gut-brain-modules in healthy adults – a systematic review protocol [version 2; peer review: 2 approved]
Background The gut microbiota has been extensively implicated in health and disease. The functional outputs of the gut microbiota, such as microbial metabolites, are considered particularly important in this regard. Significant associations exist between alterations in the relative abundance of spec...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2024-02-01
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| Series: | HRB Open Research |
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| Online Access: | https://hrbopenresearch.org/articles/6-62/v2 |
| _version_ | 1827311996742139904 |
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| author | Benjamin Valderrama David Antoine Lachmansingh John Cryan Thomaz Bastiaanssen Gerard Clarke Aonghus Lavelle |
| author_facet | Benjamin Valderrama David Antoine Lachmansingh John Cryan Thomaz Bastiaanssen Gerard Clarke Aonghus Lavelle |
| author_sort | Benjamin Valderrama |
| collection | DOAJ |
| description | Background The gut microbiota has been extensively implicated in health and disease. The functional outputs of the gut microbiota, such as microbial metabolites, are considered particularly important in this regard. Significant associations exist between alterations in the relative abundance of specific microbial taxa and mental health disorders. Dietary fiber has the potential to alter gut microbiota composition and function, modifying bacterial enzymatic function and the production of metabolites. As many taxa of microorganisms have enzymes capable of producing or degrading neurochemicals i.e. neuroactive gut brain modules, new predictive tools can be applied to existing datasets such as those harvested from dietary fiber interventions. We endeavor to perform a systematic review in order to identify studies reporting compositional gut microbiota alterations after interventions with dietary fiber in healthy individuals. We aim to also extract from the selected studies publicly available microbial genomic sequence datasets for reanalysis with a consistent bioinformatics pipeline, with the ultimate intention of identifying altered gut brain modules following dietary fiber interventions. Methods Interventional trials and randomized controlled studies that are originally published, including cross-over and non-crossover design and involving healthy adult humans will be included. A systematic search of PubMed/MEDLINE and EMBASE, two electronic databases, will be completed. Discussion Various types of dietary fiber have an impact on the gut microbiota composition, with some promoting the growth of particular taxa while others are reduced in relative abundance. Our search focuses on the impact of this food component on the microbiota of healthy individuals. Compositional gut microbial changes have been reported and our review will compile and update these observations after reanalysis of their datasets with a consistent bioinformatic pipeline. From this it may be possible to predict more detailed functional consequences in terms of neuroactive gut brain modules, of the compositional alterations in gut microbial taxa. |
| first_indexed | 2024-04-24T20:29:05Z |
| format | Article |
| id | doaj.art-7e2698f35ba641da83e03b5a8ec41caf |
| institution | Directory Open Access Journal |
| issn | 2515-4826 |
| language | English |
| last_indexed | 2024-04-24T20:29:05Z |
| publishDate | 2024-02-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | HRB Open Research |
| spelling | doaj.art-7e2698f35ba641da83e03b5a8ec41caf2024-03-22T01:00:00ZengF1000 Research LtdHRB Open Research2515-48262024-02-01615197Impact of dietary fiber on gut microbiota composition, function and gut-brain-modules in healthy adults – a systematic review protocol [version 2; peer review: 2 approved]Benjamin Valderrama0David Antoine Lachmansingh1https://orcid.org/0000-0003-2800-6431John Cryan2Thomaz Bastiaanssen3Gerard Clarke4Aonghus Lavelle5APC Microbiome Ireland, University College Cork, Cork, County Cork, IrelandDepartment of Psychiatry and Neurobehavioural Science, University College Cork, Cork, County Cork, IrelandAPC Microbiome Ireland, University College Cork, Cork, County Cork, IrelandAPC Microbiome Ireland, University College Cork, Cork, County Cork, IrelandDepartment of Psychiatry and Neurobehavioural Science, University College Cork, Cork, County Cork, IrelandAPC Microbiome Ireland, University College Cork, Cork, County Cork, IrelandBackground The gut microbiota has been extensively implicated in health and disease. The functional outputs of the gut microbiota, such as microbial metabolites, are considered particularly important in this regard. Significant associations exist between alterations in the relative abundance of specific microbial taxa and mental health disorders. Dietary fiber has the potential to alter gut microbiota composition and function, modifying bacterial enzymatic function and the production of metabolites. As many taxa of microorganisms have enzymes capable of producing or degrading neurochemicals i.e. neuroactive gut brain modules, new predictive tools can be applied to existing datasets such as those harvested from dietary fiber interventions. We endeavor to perform a systematic review in order to identify studies reporting compositional gut microbiota alterations after interventions with dietary fiber in healthy individuals. We aim to also extract from the selected studies publicly available microbial genomic sequence datasets for reanalysis with a consistent bioinformatics pipeline, with the ultimate intention of identifying altered gut brain modules following dietary fiber interventions. Methods Interventional trials and randomized controlled studies that are originally published, including cross-over and non-crossover design and involving healthy adult humans will be included. A systematic search of PubMed/MEDLINE and EMBASE, two electronic databases, will be completed. Discussion Various types of dietary fiber have an impact on the gut microbiota composition, with some promoting the growth of particular taxa while others are reduced in relative abundance. Our search focuses on the impact of this food component on the microbiota of healthy individuals. Compositional gut microbial changes have been reported and our review will compile and update these observations after reanalysis of their datasets with a consistent bioinformatic pipeline. From this it may be possible to predict more detailed functional consequences in terms of neuroactive gut brain modules, of the compositional alterations in gut microbial taxa.https://hrbopenresearch.org/articles/6-62/v2Microbiome dietary fiber gut microbes healthy individuals fiber interventioneng |
| spellingShingle | Benjamin Valderrama David Antoine Lachmansingh John Cryan Thomaz Bastiaanssen Gerard Clarke Aonghus Lavelle Impact of dietary fiber on gut microbiota composition, function and gut-brain-modules in healthy adults – a systematic review protocol [version 2; peer review: 2 approved] HRB Open Research Microbiome dietary fiber gut microbes healthy individuals fiber intervention eng |
| title | Impact of dietary fiber on gut microbiota composition, function and gut-brain-modules in healthy adults – a systematic review protocol [version 2; peer review: 2 approved] |
| title_full | Impact of dietary fiber on gut microbiota composition, function and gut-brain-modules in healthy adults – a systematic review protocol [version 2; peer review: 2 approved] |
| title_fullStr | Impact of dietary fiber on gut microbiota composition, function and gut-brain-modules in healthy adults – a systematic review protocol [version 2; peer review: 2 approved] |
| title_full_unstemmed | Impact of dietary fiber on gut microbiota composition, function and gut-brain-modules in healthy adults – a systematic review protocol [version 2; peer review: 2 approved] |
| title_short | Impact of dietary fiber on gut microbiota composition, function and gut-brain-modules in healthy adults – a systematic review protocol [version 2; peer review: 2 approved] |
| title_sort | impact of dietary fiber on gut microbiota composition function and gut brain modules in healthy adults a systematic review protocol version 2 peer review 2 approved |
| topic | Microbiome dietary fiber gut microbes healthy individuals fiber intervention eng |
| url | https://hrbopenresearch.org/articles/6-62/v2 |
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