SOME BONE METABOLIC PARAMETERS IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS
Objective: To define the specific features of bone metabolism and to estimate bone mineral density (BMD) in patients with early rheumatoid arthritis (ERA). Subjects and methods. Fifty-three patients (9 males and 44 females) with ERA were examined. Markers of bone metabolism markers were assessed, by...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
IMA PRESS LLC
2010-08-01
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| Series: | Научно-практическая ревматология |
| Subjects: | |
| Online Access: | https://rsp.mediar-press.net/rsp/article/view/1079 |
| Summary: | Objective: To define the specific features of bone metabolism and to estimate bone mineral density (BMD) in patients with early rheumatoid arthritis (ERA). Subjects and methods. Fifty-three patients (9 males and 44 females) with ERA were examined. Markers of bone metabolism markers were assessed, by measuring the serum levels of osteocalcin and C-terminal telopeptides (bCrosslaps) by electrochemoluminescence immunoassay and those of type II interleukin (IL) 1 receptor (IL1RII) and IL-6 by enzyme-linked immunosorbent assay. Bone mineral density (BMD) was studied by distal forearm densitometry (dual-energy X-ray absorptiometry) on a DexaScan DX-10 apparatus. BMD was estimated in postmenopausal women by the T-test and in men and premenopausal women by the Z-test, as well as by the absolute value of BMD (g/cm2). Results. In patients with ERA, the level of bCrosslaps was 0.50.3 ng/ml (p0.05), which is accordingly higher and lower than the reference values. There were no changes in these parameters in relation to serogroup and Xray disease stage. With higher ERA activity, there was a tendency for bCrosslaps to increase and osteocalcin to remain unchanged. There was a tendency towards decreased IL1 RII and increased proinflammatory IL-6 levels. Correlation analysis revealed a correlation between the value of BMD and the content of bCrosslaps and osteocalcin in patients with ERA and between the levels of IL-6 and bCrosslaps. Regression analysis showed a significant impact of the parameters of the course of the disease and immunological parameters on BMD changes and bone metabolism markers. Age and body mass index also affected the parameters of BMD in patients with ERA. |
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| ISSN: | 1995-4484 1995-4492 |