Matrix stiffness modulates tip cell formation through the p-PXN-Rac1-YAP signaling axis

Matrix stiffness modulates tip cell formation through the p-PXN-Rac1-YAP signaling axis

Endothelial tip cell outgrowth of blood-vessel sprouts marks the initiation of angiogenesis which is critical in physiological and pathophysiological procedures. However, how mechanical characteristics of extracellular matrix (ECM) modulates tip cell formation has been largely neglected. In this stu...

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Bibliographic Details
Main Authors: Yaru Guo, Feng Mei, Ying Huang, Siqin Ma, Yan Wei, Xuehui Zhang, Mingming Xu, Ying He, Boon Chin Heng, Lili Chen, Xuliang Deng
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-01-01
Series:Bioactive Materials
Subjects:
Tip cells
Mechanotransduction
Stiffness
Angiogenesis
Extracellular matrix
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X2100253X

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