Current progress of Atractylodes macrocephala Koidz.: A review of its biogeography, PAO-ZHI processing, biological activities, biosynthesis pathways, and technology applications
The Atractylodes macrocephala Koidz. is a traditional Chinese rhizome herb, consumed for its well-known medicinal value. This review summarizes the recent research findings on biological activities, main biosynthesis pathways, PAO-ZHI processing, and technology application. The impact of biogeograph...
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| Format: | Article |
| Language: | English |
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Maximum Academic Press
2023-02-01
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| Series: | Medicinal Plant Biology |
| Subjects: | |
| Online Access: | https://www.maxapress.com/article/doi/10.48130/MPB-2023-0005 |
| _version_ | 1797279331276292096 |
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| author | Ruiwen Yang Huiyan Fan Beihui He Qingyan Ruan Baoyu Wei Bing Han Xiaolong Hao Itay Maoz Guoyin Kai |
| author_facet | Ruiwen Yang Huiyan Fan Beihui He Qingyan Ruan Baoyu Wei Bing Han Xiaolong Hao Itay Maoz Guoyin Kai |
| author_sort | Ruiwen Yang |
| collection | DOAJ |
| description | The Atractylodes macrocephala Koidz. is a traditional Chinese rhizome herb, consumed for its well-known medicinal value. This review summarizes the recent research findings on biological activities, main biosynthesis pathways, PAO-ZHI processing, and technology application. The impact of biogeography led to significant differences in phenotypes and chemotypes. The PAO-ZHI processing also significantly affected A. macrocephala rhizome (AMR) bioactivity. A further systemic mechanistic investigation is required. Besides, new AMR polysaccharides with immunomodulatory effects, improving gastrointestinal function, and antitumor activity are constantly being isolated and characterized. Also, the discovery of novel families of compounds, such as the atractylenolides possessing antitumor, neuroprotective, immunomodulatory, and anti-inflammatory activities, is still ongoing work. Advanced genetics tools, such as in-depth transcriptomics, provide the basis for exploring A. macrocephala resources' functional genetic and molecular regulatory mechanisms. Still, some pathways are more elusive than others, and the biosynthetic pathways of sesquiterpenes, one of the prominent active families, still present a challenge in AMR and other plants. We propose here new directions and opportunities to advance current research in AMR. This review lays the theoretical foundation for fully developing and utilizing A. macrocephala resources. |
| first_indexed | 2024-03-07T16:23:45Z |
| format | Article |
| id | doaj.art-7e27f4f3e1034683bb197cc63aff8659 |
| institution | Directory Open Access Journal |
| issn | 2835-6969 |
| language | English |
| last_indexed | 2024-03-07T16:23:45Z |
| publishDate | 2023-02-01 |
| publisher | Maximum Academic Press |
| record_format | Article |
| series | Medicinal Plant Biology |
| spelling | doaj.art-7e27f4f3e1034683bb197cc63aff86592024-03-04T01:28:11ZengMaximum Academic PressMedicinal Plant Biology2835-69692023-02-012111810.48130/MPB-2023-0005MPB-2023-0005Current progress of Atractylodes macrocephala Koidz.: A review of its biogeography, PAO-ZHI processing, biological activities, biosynthesis pathways, and technology applicationsRuiwen Yang0Huiyan Fan1Beihui He2Qingyan Ruan3Baoyu Wei4Bing Han5Xiaolong Hao6Itay Maoz7Guoyin Kai8Jinhua Academy, Zhejiang Provincial International S&T Cooperation Base for Active Ingredients of Medicinal and Edible Plants and Health, Zhejiang Provincial Key TCM Laboratory for Chinese Resource Innovation and Transformation, Institute of Chinese Medicine Resource Innovation and Quality Evaluation, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, ChinaJinhua Academy, Zhejiang Provincial International S&T Cooperation Base for Active Ingredients of Medicinal and Edible Plants and Health, Zhejiang Provincial Key TCM Laboratory for Chinese Resource Innovation and Transformation, Institute of Chinese Medicine Resource Innovation and Quality Evaluation, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, ChinaJinhua Academy, Zhejiang Provincial International S&T Cooperation Base for Active Ingredients of Medicinal and Edible Plants and Health, Zhejiang Provincial Key TCM Laboratory for Chinese Resource Innovation and Transformation, Institute of Chinese Medicine Resource Innovation and Quality Evaluation, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, ChinaJinhua Academy, Zhejiang Provincial International S&T Cooperation Base for Active Ingredients of Medicinal and Edible Plants and Health, Zhejiang Provincial Key TCM Laboratory for Chinese Resource Innovation and Transformation, Institute of Chinese Medicine Resource Innovation and Quality Evaluation, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, ChinaJinhua Academy, Zhejiang Provincial International S&T Cooperation Base for Active Ingredients of Medicinal and Edible Plants and Health, Zhejiang Provincial Key TCM Laboratory for Chinese Resource Innovation and Transformation, Institute of Chinese Medicine Resource Innovation and Quality Evaluation, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, ChinaJinhua Academy, Zhejiang Provincial International S&T Cooperation Base for Active Ingredients of Medicinal and Edible Plants and Health, Zhejiang Provincial Key TCM Laboratory for Chinese Resource Innovation and Transformation, Institute of Chinese Medicine Resource Innovation and Quality Evaluation, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, ChinaJinhua Academy, Zhejiang Provincial International S&T Cooperation Base for Active Ingredients of Medicinal and Edible Plants and Health, Zhejiang Provincial Key TCM Laboratory for Chinese Resource Innovation and Transformation, Institute of Chinese Medicine Resource Innovation and Quality Evaluation, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, ChinaDepartment of Postharvest Science, Agricultural Research Organization, Volcani Center, PO Box 15159, HaMaccabim Road 68, Rishon LeZion 7505101, IsraelJinhua Academy, Zhejiang Provincial International S&T Cooperation Base for Active Ingredients of Medicinal and Edible Plants and Health, Zhejiang Provincial Key TCM Laboratory for Chinese Resource Innovation and Transformation, Institute of Chinese Medicine Resource Innovation and Quality Evaluation, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, ChinaThe Atractylodes macrocephala Koidz. is a traditional Chinese rhizome herb, consumed for its well-known medicinal value. This review summarizes the recent research findings on biological activities, main biosynthesis pathways, PAO-ZHI processing, and technology application. The impact of biogeography led to significant differences in phenotypes and chemotypes. The PAO-ZHI processing also significantly affected A. macrocephala rhizome (AMR) bioactivity. A further systemic mechanistic investigation is required. Besides, new AMR polysaccharides with immunomodulatory effects, improving gastrointestinal function, and antitumor activity are constantly being isolated and characterized. Also, the discovery of novel families of compounds, such as the atractylenolides possessing antitumor, neuroprotective, immunomodulatory, and anti-inflammatory activities, is still ongoing work. Advanced genetics tools, such as in-depth transcriptomics, provide the basis for exploring A. macrocephala resources' functional genetic and molecular regulatory mechanisms. Still, some pathways are more elusive than others, and the biosynthetic pathways of sesquiterpenes, one of the prominent active families, still present a challenge in AMR and other plants. We propose here new directions and opportunities to advance current research in AMR. This review lays the theoretical foundation for fully developing and utilizing A. macrocephala resources.https://www.maxapress.com/article/doi/10.48130/MPB-2023-0005atractylodes macrocephala koidz.origin distributionbiological activitiesbiosynthetic pathwaystranscriptome sequencing |
| spellingShingle | Ruiwen Yang Huiyan Fan Beihui He Qingyan Ruan Baoyu Wei Bing Han Xiaolong Hao Itay Maoz Guoyin Kai Current progress of Atractylodes macrocephala Koidz.: A review of its biogeography, PAO-ZHI processing, biological activities, biosynthesis pathways, and technology applications Medicinal Plant Biology atractylodes macrocephala koidz. origin distribution biological activities biosynthetic pathways transcriptome sequencing |
| title | Current progress of Atractylodes macrocephala Koidz.: A review of its biogeography, PAO-ZHI processing, biological activities, biosynthesis pathways, and technology applications |
| title_full | Current progress of Atractylodes macrocephala Koidz.: A review of its biogeography, PAO-ZHI processing, biological activities, biosynthesis pathways, and technology applications |
| title_fullStr | Current progress of Atractylodes macrocephala Koidz.: A review of its biogeography, PAO-ZHI processing, biological activities, biosynthesis pathways, and technology applications |
| title_full_unstemmed | Current progress of Atractylodes macrocephala Koidz.: A review of its biogeography, PAO-ZHI processing, biological activities, biosynthesis pathways, and technology applications |
| title_short | Current progress of Atractylodes macrocephala Koidz.: A review of its biogeography, PAO-ZHI processing, biological activities, biosynthesis pathways, and technology applications |
| title_sort | current progress of atractylodes macrocephala koidz a review of its biogeography pao zhi processing biological activities biosynthesis pathways and technology applications |
| topic | atractylodes macrocephala koidz. origin distribution biological activities biosynthetic pathways transcriptome sequencing |
| url | https://www.maxapress.com/article/doi/10.48130/MPB-2023-0005 |
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