The effect of bariatric surgery on purine metabolism and gout
Gout is an auto-inflammatory tophaceous disease characterized by the deposition of crystals of monosodium urate and developing in connection with this inflammation in people with hyperuricemia (HU). Except to genetic factors, risk factors for the development of HU and gout are many modifiable factor...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2020-09-01
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| Series: | Ожирение и метаболизм |
| Subjects: | |
| Online Access: | https://www.omet-endojournals.ru/jour/article/view/12109 |
| _version_ | 1797204608701956096 |
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| author | Taras S. Panevin Maxim S. Eliseev Marina V. Shestakova |
| author_facet | Taras S. Panevin Maxim S. Eliseev Marina V. Shestakova |
| author_sort | Taras S. Panevin |
| collection | DOAJ |
| description | Gout is an auto-inflammatory tophaceous disease characterized by the deposition of crystals of monosodium urate and developing in connection with this inflammation in people with hyperuricemia (HU). Except to genetic factors, risk factors for the development of HU and gout are many modifiable factors, including metabolic syndrome and obesity, and their correction is the most important component of successful disease control. Obesity can change the clinical picture of gout, characterized by an earlier onset, a large number of affected joints. Weight loss helps reduce uric acid (UA) serum levels. Bariatric / metabolic surgery significantly reduces the incidence of comorbid obesity and mortality, and is by far the most effective way to combat obesity. In addition to improving health, an important goal of bariatric surgery is to improve the quality of life. Bariatric surgery can prevent the development of HU in subjects with an initially normal level of serum UA before surgery. The dynamics of the concentration of UA in serum can be a predictor of successful bariatric surgery and help in predicting the severity of postoperative weight loss. The decrease in body weight after bariatric surgery leads to a decrease in UA in the long-term postoperative period, however, there is a high frequency of acute gout attacks in the early postoperative period. Thus, bariatric surgery has a significant effect on HU and gout and can be an effective treatment for this disease. |
| first_indexed | 2024-03-08T09:13:17Z |
| format | Article |
| id | doaj.art-7e28798a4add4f7fbb8491f97b08aaa0 |
| institution | Directory Open Access Journal |
| issn | 2071-8713 2306-5524 |
| language | English |
| last_indexed | 2024-04-24T08:37:56Z |
| publishDate | 2020-09-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Ожирение и метаболизм |
| spelling | doaj.art-7e28798a4add4f7fbb8491f97b08aaa02024-04-16T16:16:12ZengEndocrinology Research CentreОжирение и метаболизм2071-87132306-55242020-09-0117213814610.14341/omet1210910681The effect of bariatric surgery on purine metabolism and goutTaras S. Panevin0Maxim S. Eliseev1Marina V. Shestakova2V.A. Nasonova Research Institute of Rheumatology; Endocrinology Research Centre; Advisory and Diagnostic center of the General Staff of the Armed Forces of the Russian FederationV.A. Nasonova Research Institute of RheumatologyEndocrinology Research CentreGout is an auto-inflammatory tophaceous disease characterized by the deposition of crystals of monosodium urate and developing in connection with this inflammation in people with hyperuricemia (HU). Except to genetic factors, risk factors for the development of HU and gout are many modifiable factors, including metabolic syndrome and obesity, and their correction is the most important component of successful disease control. Obesity can change the clinical picture of gout, characterized by an earlier onset, a large number of affected joints. Weight loss helps reduce uric acid (UA) serum levels. Bariatric / metabolic surgery significantly reduces the incidence of comorbid obesity and mortality, and is by far the most effective way to combat obesity. In addition to improving health, an important goal of bariatric surgery is to improve the quality of life. Bariatric surgery can prevent the development of HU in subjects with an initially normal level of serum UA before surgery. The dynamics of the concentration of UA in serum can be a predictor of successful bariatric surgery and help in predicting the severity of postoperative weight loss. The decrease in body weight after bariatric surgery leads to a decrease in UA in the long-term postoperative period, however, there is a high frequency of acute gout attacks in the early postoperative period. Thus, bariatric surgery has a significant effect on HU and gout and can be an effective treatment for this disease.https://www.omet-endojournals.ru/jour/article/view/12109obesitygouthyperuricemiauric acidtype 2 diabetesbariatric surgery |
| spellingShingle | Taras S. Panevin Maxim S. Eliseev Marina V. Shestakova The effect of bariatric surgery on purine metabolism and gout Ожирение и метаболизм obesity gout hyperuricemia uric acid type 2 diabetes bariatric surgery |
| title | The effect of bariatric surgery on purine metabolism and gout |
| title_full | The effect of bariatric surgery on purine metabolism and gout |
| title_fullStr | The effect of bariatric surgery on purine metabolism and gout |
| title_full_unstemmed | The effect of bariatric surgery on purine metabolism and gout |
| title_short | The effect of bariatric surgery on purine metabolism and gout |
| title_sort | effect of bariatric surgery on purine metabolism and gout |
| topic | obesity gout hyperuricemia uric acid type 2 diabetes bariatric surgery |
| url | https://www.omet-endojournals.ru/jour/article/view/12109 |
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