Repulsive expansion dynamics in colony growth and gene expression.
Spatial expansion of a population of cells can arise from growth of microorganisms, plant cells, and mammalian cells. It underlies normal or dysfunctional tissue development, and it can be exploited as the foundation for programming spatial patterns. This expansion is often driven by continuous grow...
| Main Authors: | , , , , |
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| 格式: | 文件 |
| 语言: | English |
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Public Library of Science (PLoS)
2021-03-01
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| 丛编: | PLoS Computational Biology |
| 在线阅读: | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008168&type=printable |
| _version_ | 1826554817688895488 |
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| author | Yangxiaolu Cao John Neu Andrew E Blanchard Ting Lu Lingchong You |
| author_facet | Yangxiaolu Cao John Neu Andrew E Blanchard Ting Lu Lingchong You |
| author_sort | Yangxiaolu Cao |
| collection | DOAJ |
| description | Spatial expansion of a population of cells can arise from growth of microorganisms, plant cells, and mammalian cells. It underlies normal or dysfunctional tissue development, and it can be exploited as the foundation for programming spatial patterns. This expansion is often driven by continuous growth and division of cells within a colony, which in turn pushes the peripheral cells outward. This process generates a repulsion velocity field at each location within the colony. Here we show that this process can be approximated as coarse-grained repulsive-expansion kinetics. This framework enables accurate and efficient simulation of growth and gene expression dynamics in radially symmetric colonies with homogenous z-directional distribution. It is robust even if cells are not spherical and vary in size. The simplicity of the resulting mathematical framework also greatly facilitates generation of mechanistic insights. |
| first_indexed | 2024-12-21T00:35:32Z |
| format | Article |
| id | doaj.art-7e2a658e265040a29fa4128e655fc9be |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2025-03-14T07:46:57Z |
| publishDate | 2021-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-7e2a658e265040a29fa4128e655fc9be2025-03-03T05:31:35ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582021-03-01173e100816810.1371/journal.pcbi.1008168Repulsive expansion dynamics in colony growth and gene expression.Yangxiaolu CaoJohn NeuAndrew E BlanchardTing LuLingchong YouSpatial expansion of a population of cells can arise from growth of microorganisms, plant cells, and mammalian cells. It underlies normal or dysfunctional tissue development, and it can be exploited as the foundation for programming spatial patterns. This expansion is often driven by continuous growth and division of cells within a colony, which in turn pushes the peripheral cells outward. This process generates a repulsion velocity field at each location within the colony. Here we show that this process can be approximated as coarse-grained repulsive-expansion kinetics. This framework enables accurate and efficient simulation of growth and gene expression dynamics in radially symmetric colonies with homogenous z-directional distribution. It is robust even if cells are not spherical and vary in size. The simplicity of the resulting mathematical framework also greatly facilitates generation of mechanistic insights.https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008168&type=printable |
| spellingShingle | Yangxiaolu Cao John Neu Andrew E Blanchard Ting Lu Lingchong You Repulsive expansion dynamics in colony growth and gene expression. PLoS Computational Biology |
| title | Repulsive expansion dynamics in colony growth and gene expression. |
| title_full | Repulsive expansion dynamics in colony growth and gene expression. |
| title_fullStr | Repulsive expansion dynamics in colony growth and gene expression. |
| title_full_unstemmed | Repulsive expansion dynamics in colony growth and gene expression. |
| title_short | Repulsive expansion dynamics in colony growth and gene expression. |
| title_sort | repulsive expansion dynamics in colony growth and gene expression |
| url | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008168&type=printable |
| work_keys_str_mv | AT yangxiaolucao repulsiveexpansiondynamicsincolonygrowthandgeneexpression AT johnneu repulsiveexpansiondynamicsincolonygrowthandgeneexpression AT andreweblanchard repulsiveexpansiondynamicsincolonygrowthandgeneexpression AT tinglu repulsiveexpansiondynamicsincolonygrowthandgeneexpression AT lingchongyou repulsiveexpansiondynamicsincolonygrowthandgeneexpression |