Chronic NKG2D Engagement In Vivo Differentially Impacts NK Cell Responsiveness by Activating NK Receptors

Chronic NKG2D Engagement In Vivo Differentially Impacts NK Cell Responsiveness by Activating NK Receptors

Immunosuppression is a typical hallmark of cancer and frequently includes perturbations of the NKG2D tumor recognition system as well as impaired signaling by other activating NK cell receptors. Several in vitro studies suggested that sustained engagement of the NKG2D receptor, as it is occurring in...

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Bibliographic Details
Main Authors: Christine Koch, Younghoon Kim, Tobias Zöller, Christina Born, Alexander Steinle
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
NKG2D
NK cells
MICA
signal transduction
NK receptors
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01466/full

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