Novel Functionalized Spiro [Indoline-3,5′-pyrroline]-2,2′dione Derivatives: Synthesis, Characterization, Drug-Likeness, ADME, and Anticancer Potential

Novel Functionalized Spiro [Indoline-3,5′-pyrroline]-2,2′dione Derivatives: Synthesis, Characterization, Drug-Likeness, ADME, and Anticancer Potential

A highly stereo-selective, one-pot, multicomponent method was chosen to synthesize the novel functionalized 1, 3-cycloaddition spirooxindoles (SOXs) (<b>4a</b>–<b>4h</b>). Synthesized SOXs were analyzed for their drug-likeness and ADME parameters and screened for their antica...

Full description

Bibliographic Details
Main Authors: Mohd Asif, Sahir Sultan Alvi, Tazeen Azaz, Abdul Rahman Khan, Bhoopendra Tiwari, Bilal Bin Hafeez, Malik Nasibullah
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
isatin-derived spirooxindoles (SOXs)
cancer cells
drug-likeness
ADMET studies
ROS generation
and anticancer effects
Online Access:https://www.mdpi.com/1422-0067/24/8/7336

Internet

https://www.mdpi.com/1422-0067/24/8/7336

Similar Items