Co-Opting Host Receptors for Targeted Delivery of Bioconjugates—From Drugs to Bugs
Bioconjugation has allowed scientists to combine multiple functional elements into one biological or biochemical unit. This assembly can result in the production of constructs that are targeted to a specific site or cell type in order to enhance the response to, or activity of, the conjugated moiety...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/5/1479 |
| _version_ | 1797542120874049536 |
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| author | Kristen M. Tummillo Karsten R.O. Hazlett |
| author_facet | Kristen M. Tummillo Karsten R.O. Hazlett |
| author_sort | Kristen M. Tummillo |
| collection | DOAJ |
| description | Bioconjugation has allowed scientists to combine multiple functional elements into one biological or biochemical unit. This assembly can result in the production of constructs that are targeted to a specific site or cell type in order to enhance the response to, or activity of, the conjugated moiety. In the case of cancer treatments, selectively targeting chemotherapies to the cells of interest limit harmful side effects and enhance efficacy. Targeting through conjugation is also advantageous in delivering treatments to difficult-to-reach tissues, such as the brain or infections deep in the lung. Bacterial infections can be more selectively treated by conjugating antibiotics to microbe-specific entities; helping to avoid antibiotic resistance across commensal bacterial species. In the case of vaccine development, conjugation is used to enhance efficacy without compromising safety. In this work, we will review the previously mentioned areas in which bioconjugation has created new possibilities and advanced treatments. |
| first_indexed | 2024-03-10T13:25:12Z |
| format | Article |
| id | doaj.art-7e2b5d9c4a88438b9f835c835adade57 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T13:25:12Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-7e2b5d9c4a88438b9f835c835adade572023-11-21T09:42:36ZengMDPI AGMolecules1420-30492021-03-01265147910.3390/molecules26051479Co-Opting Host Receptors for Targeted Delivery of Bioconjugates—From Drugs to BugsKristen M. Tummillo0Karsten R.O. Hazlett1Department of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY 12208, USADepartment of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY 12208, USABioconjugation has allowed scientists to combine multiple functional elements into one biological or biochemical unit. This assembly can result in the production of constructs that are targeted to a specific site or cell type in order to enhance the response to, or activity of, the conjugated moiety. In the case of cancer treatments, selectively targeting chemotherapies to the cells of interest limit harmful side effects and enhance efficacy. Targeting through conjugation is also advantageous in delivering treatments to difficult-to-reach tissues, such as the brain or infections deep in the lung. Bacterial infections can be more selectively treated by conjugating antibiotics to microbe-specific entities; helping to avoid antibiotic resistance across commensal bacterial species. In the case of vaccine development, conjugation is used to enhance efficacy without compromising safety. In this work, we will review the previously mentioned areas in which bioconjugation has created new possibilities and advanced treatments.https://www.mdpi.com/1420-3049/26/5/1479antibody–drug conjugatesdrug deliveryvaccinesantibioticsconjugated vaccinestargeted vaccines |
| spellingShingle | Kristen M. Tummillo Karsten R.O. Hazlett Co-Opting Host Receptors for Targeted Delivery of Bioconjugates—From Drugs to Bugs Molecules antibody–drug conjugates drug delivery vaccines antibiotics conjugated vaccines targeted vaccines |
| title | Co-Opting Host Receptors for Targeted Delivery of Bioconjugates—From Drugs to Bugs |
| title_full | Co-Opting Host Receptors for Targeted Delivery of Bioconjugates—From Drugs to Bugs |
| title_fullStr | Co-Opting Host Receptors for Targeted Delivery of Bioconjugates—From Drugs to Bugs |
| title_full_unstemmed | Co-Opting Host Receptors for Targeted Delivery of Bioconjugates—From Drugs to Bugs |
| title_short | Co-Opting Host Receptors for Targeted Delivery of Bioconjugates—From Drugs to Bugs |
| title_sort | co opting host receptors for targeted delivery of bioconjugates from drugs to bugs |
| topic | antibody–drug conjugates drug delivery vaccines antibiotics conjugated vaccines targeted vaccines |
| url | https://www.mdpi.com/1420-3049/26/5/1479 |
| work_keys_str_mv | AT kristenmtummillo cooptinghostreceptorsfortargeteddeliveryofbioconjugatesfromdrugstobugs AT karstenrohazlett cooptinghostreceptorsfortargeteddeliveryofbioconjugatesfromdrugstobugs |