Clinical findings, viral load, and outcomes of COVID-19: Comparison of patients with negative and positive initial chest computed tomography
Reports detailing the clinical characteristics, viral load, and outcomes of patients with normal initial chest CT findings are lacking. We sought to compare the differences in clinical findings, viral loads, and outcomes between patients with confirmed COVID-19 who initially tested negative on chest...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893619/?tool=EBI |
| _version_ | 1818920668408840192 |
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| author | Cherry Kim Ji-Yeon Kim Eun Joo Lee Yu Min Kang Kyoung-Ho Song Eu Suk Kim Eun Jin Kim Seungsoo Sheen Yoo Ra Lee BeoDeul Kang Joon Ho Kim Myoung Lyeol Woo Chul Hee Park Soohoon Kwon Eun Ju Choo Tark Kim Donghoon Kim Hong Sang Oh Won Suk Choi |
| author_facet | Cherry Kim Ji-Yeon Kim Eun Joo Lee Yu Min Kang Kyoung-Ho Song Eu Suk Kim Eun Jin Kim Seungsoo Sheen Yoo Ra Lee BeoDeul Kang Joon Ho Kim Myoung Lyeol Woo Chul Hee Park Soohoon Kwon Eun Ju Choo Tark Kim Donghoon Kim Hong Sang Oh Won Suk Choi |
| author_sort | Cherry Kim |
| collection | DOAJ |
| description | Reports detailing the clinical characteristics, viral load, and outcomes of patients with normal initial chest CT findings are lacking. We sought to compare the differences in clinical findings, viral loads, and outcomes between patients with confirmed COVID-19 who initially tested negative on chest CT (CT negative) with patients who tested initially positive on chest CT (CT positive). The clinical data, viral loads, and outcomes of initial CT-positive and CT-negative patients examined between January 2020 and April 2020 were retrospectively compared. The efficacy of viral load (cyclic threshold value [Ct value]) in predicting pneumonia was evaluated using receiver operating characteristic (ROC) curve and area under the curve (AUC). In total, 128 patients underwent initial chest CT (mean age, 54.3 ± 19.0 years, 50% male). Of those, 36 were initially CT negative, and 92 were CT positive. The CT-positive patients were significantly older (P < .001) than the CT-negative patients. Only age was significantly associated with the initial presence of pneumonia (odds ratio, 1.060; confidence interval (CI), 1.020-1-102; P = .003). In addition, age (OR, 1.062; CI, 1.014–1.112; P = .011), fever at diagnosis (OR, 6.689; CI, 1.715–26.096; P = .006), and CRP level (OR, 1.393; CI, 1.150–1.687; P = .001) were significantly associated with the need for O2 therapy. Viral load was significantly higher in the CT-positive group than in the CT-negative group (P = .017). The cutoff Ct value for predicting the presence of pneumonia was 27.71. Outcomes including the mean hospital stay, intensive care unit admission, and O2 therapy were significantly worse in the CT-positive group than in the CT-negative group (all P < .05). In conclusion, initially CT-negative patients showed better outcomes than initially CT-positive patients. Age was significantly associated with the initial presence of pneumonia, and viral load may help in predicting the initial presence of pneumonia. |
| first_indexed | 2024-12-20T01:25:25Z |
| format | Article |
| id | doaj.art-7e2bb58bc3cb40c288e3558163a6b52d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T01:25:25Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7e2bb58bc3cb40c288e3558163a6b52d2022-12-21T19:58:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01173Clinical findings, viral load, and outcomes of COVID-19: Comparison of patients with negative and positive initial chest computed tomographyCherry KimJi-Yeon KimEun Joo LeeYu Min KangKyoung-Ho SongEu Suk KimEun Jin KimSeungsoo SheenYoo Ra LeeBeoDeul KangJoon Ho KimMyoung Lyeol WooChul Hee ParkSoohoon KwonEun Ju ChooTark KimDonghoon KimHong Sang OhWon Suk ChoiReports detailing the clinical characteristics, viral load, and outcomes of patients with normal initial chest CT findings are lacking. We sought to compare the differences in clinical findings, viral loads, and outcomes between patients with confirmed COVID-19 who initially tested negative on chest CT (CT negative) with patients who tested initially positive on chest CT (CT positive). The clinical data, viral loads, and outcomes of initial CT-positive and CT-negative patients examined between January 2020 and April 2020 were retrospectively compared. The efficacy of viral load (cyclic threshold value [Ct value]) in predicting pneumonia was evaluated using receiver operating characteristic (ROC) curve and area under the curve (AUC). In total, 128 patients underwent initial chest CT (mean age, 54.3 ± 19.0 years, 50% male). Of those, 36 were initially CT negative, and 92 were CT positive. The CT-positive patients were significantly older (P < .001) than the CT-negative patients. Only age was significantly associated with the initial presence of pneumonia (odds ratio, 1.060; confidence interval (CI), 1.020-1-102; P = .003). In addition, age (OR, 1.062; CI, 1.014–1.112; P = .011), fever at diagnosis (OR, 6.689; CI, 1.715–26.096; P = .006), and CRP level (OR, 1.393; CI, 1.150–1.687; P = .001) were significantly associated with the need for O2 therapy. Viral load was significantly higher in the CT-positive group than in the CT-negative group (P = .017). The cutoff Ct value for predicting the presence of pneumonia was 27.71. Outcomes including the mean hospital stay, intensive care unit admission, and O2 therapy were significantly worse in the CT-positive group than in the CT-negative group (all P < .05). In conclusion, initially CT-negative patients showed better outcomes than initially CT-positive patients. Age was significantly associated with the initial presence of pneumonia, and viral load may help in predicting the initial presence of pneumonia.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893619/?tool=EBI |
| spellingShingle | Cherry Kim Ji-Yeon Kim Eun Joo Lee Yu Min Kang Kyoung-Ho Song Eu Suk Kim Eun Jin Kim Seungsoo Sheen Yoo Ra Lee BeoDeul Kang Joon Ho Kim Myoung Lyeol Woo Chul Hee Park Soohoon Kwon Eun Ju Choo Tark Kim Donghoon Kim Hong Sang Oh Won Suk Choi Clinical findings, viral load, and outcomes of COVID-19: Comparison of patients with negative and positive initial chest computed tomography PLoS ONE |
| title | Clinical findings, viral load, and outcomes of COVID-19: Comparison of patients with negative and positive initial chest computed tomography |
| title_full | Clinical findings, viral load, and outcomes of COVID-19: Comparison of patients with negative and positive initial chest computed tomography |
| title_fullStr | Clinical findings, viral load, and outcomes of COVID-19: Comparison of patients with negative and positive initial chest computed tomography |
| title_full_unstemmed | Clinical findings, viral load, and outcomes of COVID-19: Comparison of patients with negative and positive initial chest computed tomography |
| title_short | Clinical findings, viral load, and outcomes of COVID-19: Comparison of patients with negative and positive initial chest computed tomography |
| title_sort | clinical findings viral load and outcomes of covid 19 comparison of patients with negative and positive initial chest computed tomography |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893619/?tool=EBI |
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