Role of ubiquitination in IGF-1 receptor signaling and degradation.

Role of ubiquitination in IGF-1 receptor signaling and degradation.

BACKGROUND: The insulin-like growth factor 1 receptor (IGF-1R) plays numerous crucial roles in cancer biology. The majority of knowledge on IGF-1R signaling is concerned with its role in the activation of the canonical phosphatidyl inositol-3 kinase (PI3K)/Akt and MAPK/ERK pathways. However, the rol...

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Bibliographic Details
Main Authors:	Bita Sehat, Sandra Andersson, Radu Vasilcanu, Leonard Girnita, Olle Larsson
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2007-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC1838569?pdf=render

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