Vitamin D Levels in Pregnant Women Do Not Affect Neonatal Bone Strength
Vitamin D plays a key role in regulating calcium and phosphate metabolism. However, whether maternal vitamin D levels affect fetal bone strength is unclear. This study assessed correlations between maternal 25(OH)D status and neonatal bone strength 25(OH)D levels, these were measured in the maternal...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/9/6/883 |
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| author | Orly Levkovitz Elena Lagerev Sofia Bauer-Rusak Ita Litmanovitz Eynit Grinblatt Gisela Laura Sirota Shachar Shalit Shmuel Arnon |
| author_facet | Orly Levkovitz Elena Lagerev Sofia Bauer-Rusak Ita Litmanovitz Eynit Grinblatt Gisela Laura Sirota Shachar Shalit Shmuel Arnon |
| author_sort | Orly Levkovitz |
| collection | DOAJ |
| description | Vitamin D plays a key role in regulating calcium and phosphate metabolism. However, whether maternal vitamin D levels affect fetal bone strength is unclear. This study assessed correlations between maternal 25(OH)D status and neonatal bone strength 25(OH)D levels, these were measured in the maternal and infant cord blood of 81 mother–infant dyads. Bone strength was measured using a quantitative ultrasound (QUS) of tibial bone speed of sound (SOS). Maternal vitamin D intake, medical history and lifestyle were evaluated from questionnaires. Maternal 25(OH)D levels were deficient (<25 nmol/L) in 24.7%, insufficient (25–50 nmol/L) in 37% and sufficient (>50 nmol/L) in 38.3%. The maternal and cord blood 25(OH)D levels correlated (r = 0.85, <i>p</i> < 0.001). Cord blood levels (57.9 ± 33.5 nmol/L) were higher than the maternal blood levels (46.3 ± 23.2: <i>p</i> < 0.001). The mean SOS was 3042 ± 130 m/s. The neonatal SOS and 25(OH)D levels were not correlated. The mean bone SOS levels were comparable in the three maternal and cord blood 25(OH)D groups. No correlation was found between the maternal 25(OH)D levels and the neonatal anthropometrics. Although the 25(OH)D levels were higher in Jewish mothers than they were in Muslim mothers (51.1 ± 22.6 nmol/L vs. 24 ± 14.7 nmol/L, respectively: <i>p</i> = 0.002) and in those who took supplemental vitamin D, the bone SOS levels were comparable. In conclusion, maternal vitamin D levels correlate with cord levels but do not affect bone strength or growth parameters. |
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| id | doaj.art-7e2d11d1103949ab9d3d23333a880a23 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T00:07:17Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-7e2d11d1103949ab9d3d23333a880a232023-11-23T16:06:24ZengMDPI AGChildren2227-90672022-06-019688310.3390/children9060883Vitamin D Levels in Pregnant Women Do Not Affect Neonatal Bone StrengthOrly Levkovitz0Elena Lagerev1Sofia Bauer-Rusak2Ita Litmanovitz3Eynit Grinblatt4Gisela Laura Sirota5Shachar Shalit6Shmuel Arnon7Department of Neonatology, Meir Medical Center, Kfar Saba 4428163, IsraelDepartment of Neonatology, Assuta-Ashdod Medical Center, Ashdod 7747629, IsraelDepartment of Neonatology, Meir Medical Center, Kfar Saba 4428163, IsraelDepartment of Neonatology, Meir Medical Center, Kfar Saba 4428163, IsraelDepartment of Neonatology, Meir Medical Center, Kfar Saba 4428163, IsraelDepartment of Neonatology, Meir Medical Center, Kfar Saba 4428163, IsraelDepartment of Neonatology, Meir Medical Center, Kfar Saba 4428163, IsraelDepartment of Neonatology, Meir Medical Center, Kfar Saba 4428163, IsraelVitamin D plays a key role in regulating calcium and phosphate metabolism. However, whether maternal vitamin D levels affect fetal bone strength is unclear. This study assessed correlations between maternal 25(OH)D status and neonatal bone strength 25(OH)D levels, these were measured in the maternal and infant cord blood of 81 mother–infant dyads. Bone strength was measured using a quantitative ultrasound (QUS) of tibial bone speed of sound (SOS). Maternal vitamin D intake, medical history and lifestyle were evaluated from questionnaires. Maternal 25(OH)D levels were deficient (<25 nmol/L) in 24.7%, insufficient (25–50 nmol/L) in 37% and sufficient (>50 nmol/L) in 38.3%. The maternal and cord blood 25(OH)D levels correlated (r = 0.85, <i>p</i> < 0.001). Cord blood levels (57.9 ± 33.5 nmol/L) were higher than the maternal blood levels (46.3 ± 23.2: <i>p</i> < 0.001). The mean SOS was 3042 ± 130 m/s. The neonatal SOS and 25(OH)D levels were not correlated. The mean bone SOS levels were comparable in the three maternal and cord blood 25(OH)D groups. No correlation was found between the maternal 25(OH)D levels and the neonatal anthropometrics. Although the 25(OH)D levels were higher in Jewish mothers than they were in Muslim mothers (51.1 ± 22.6 nmol/L vs. 24 ± 14.7 nmol/L, respectively: <i>p</i> = 0.002) and in those who took supplemental vitamin D, the bone SOS levels were comparable. In conclusion, maternal vitamin D levels correlate with cord levels but do not affect bone strength or growth parameters.https://www.mdpi.com/2227-9067/9/6/883neonatepregnancyquantitative ultrasoundspeed of sound25-hydroxy vitamin Dbone strength |
| spellingShingle | Orly Levkovitz Elena Lagerev Sofia Bauer-Rusak Ita Litmanovitz Eynit Grinblatt Gisela Laura Sirota Shachar Shalit Shmuel Arnon Vitamin D Levels in Pregnant Women Do Not Affect Neonatal Bone Strength Children neonate pregnancy quantitative ultrasound speed of sound 25-hydroxy vitamin D bone strength |
| title | Vitamin D Levels in Pregnant Women Do Not Affect Neonatal Bone Strength |
| title_full | Vitamin D Levels in Pregnant Women Do Not Affect Neonatal Bone Strength |
| title_fullStr | Vitamin D Levels in Pregnant Women Do Not Affect Neonatal Bone Strength |
| title_full_unstemmed | Vitamin D Levels in Pregnant Women Do Not Affect Neonatal Bone Strength |
| title_short | Vitamin D Levels in Pregnant Women Do Not Affect Neonatal Bone Strength |
| title_sort | vitamin d levels in pregnant women do not affect neonatal bone strength |
| topic | neonate pregnancy quantitative ultrasound speed of sound 25-hydroxy vitamin D bone strength |
| url | https://www.mdpi.com/2227-9067/9/6/883 |
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