Therapeutic Targeting of RNA Splicing in Cancer
RNA splicing is a key regulatory step in the proper control of gene expression. It is a highly dynamic process orchestrated by the spliceosome, a macro-molecular machinery that consists of protein and RNA components. The dysregulation of RNA splicing has been observed in many human pathologies rangi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Genes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4425/14/7/1378 |
| _version_ | 1797589180165914624 |
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| author | Elizabeth A. Bonner Stanley C. Lee |
| author_facet | Elizabeth A. Bonner Stanley C. Lee |
| author_sort | Elizabeth A. Bonner |
| collection | DOAJ |
| description | RNA splicing is a key regulatory step in the proper control of gene expression. It is a highly dynamic process orchestrated by the spliceosome, a macro-molecular machinery that consists of protein and RNA components. The dysregulation of RNA splicing has been observed in many human pathologies ranging from neurodegenerative diseases to cancer. The recent identification of recurrent mutations in the core components of the spliceosome in hematologic malignancies has advanced our knowledge of how splicing alterations contribute to disease pathogenesis. This review article will discuss our current understanding of how aberrant RNA splicing regulation drives tumor initiation and progression. We will also review current therapeutic modalities and highlight emerging technologies designed to target RNA splicing for cancer treatment. |
| first_indexed | 2024-03-11T01:02:45Z |
| format | Article |
| id | doaj.art-7e2d84932c9c4f4f8b709999c4682ec0 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-11T01:02:45Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-7e2d84932c9c4f4f8b709999c4682ec02023-11-18T19:29:33ZengMDPI AGGenes2073-44252023-06-01147137810.3390/genes14071378Therapeutic Targeting of RNA Splicing in CancerElizabeth A. Bonner0Stanley C. Lee1Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USATranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USARNA splicing is a key regulatory step in the proper control of gene expression. It is a highly dynamic process orchestrated by the spliceosome, a macro-molecular machinery that consists of protein and RNA components. The dysregulation of RNA splicing has been observed in many human pathologies ranging from neurodegenerative diseases to cancer. The recent identification of recurrent mutations in the core components of the spliceosome in hematologic malignancies has advanced our knowledge of how splicing alterations contribute to disease pathogenesis. This review article will discuss our current understanding of how aberrant RNA splicing regulation drives tumor initiation and progression. We will also review current therapeutic modalities and highlight emerging technologies designed to target RNA splicing for cancer treatment.https://www.mdpi.com/2073-4425/14/7/1378alternative splicingsplicing factor mutationsspliceosome inhibitorsanti-sense oligonucleotidesimmuno-oncology therapies |
| spellingShingle | Elizabeth A. Bonner Stanley C. Lee Therapeutic Targeting of RNA Splicing in Cancer Genes alternative splicing splicing factor mutations spliceosome inhibitors anti-sense oligonucleotides immuno-oncology therapies |
| title | Therapeutic Targeting of RNA Splicing in Cancer |
| title_full | Therapeutic Targeting of RNA Splicing in Cancer |
| title_fullStr | Therapeutic Targeting of RNA Splicing in Cancer |
| title_full_unstemmed | Therapeutic Targeting of RNA Splicing in Cancer |
| title_short | Therapeutic Targeting of RNA Splicing in Cancer |
| title_sort | therapeutic targeting of rna splicing in cancer |
| topic | alternative splicing splicing factor mutations spliceosome inhibitors anti-sense oligonucleotides immuno-oncology therapies |
| url | https://www.mdpi.com/2073-4425/14/7/1378 |
| work_keys_str_mv | AT elizabethabonner therapeutictargetingofrnasplicingincancer AT stanleyclee therapeutictargetingofrnasplicingincancer |