Therapeutic Targeting of RNA Splicing in Cancer
RNA splicing is a key regulatory step in the proper control of gene expression. It is a highly dynamic process orchestrated by the spliceosome, a macro-molecular machinery that consists of protein and RNA components. The dysregulation of RNA splicing has been observed in many human pathologies rangi...
Main Authors: | Elizabeth A. Bonner, Stanley C. Lee |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-06-01
|
Series: | Genes |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4425/14/7/1378 |
Similar Items
-
Aberrant RNA Splicing in Cancer and Drug Resistance
by: Bi-Dar Wang, et al.
Published: (2018-11-01) -
Editorial: Therapeutic targeting of splicing variants in cancer
by: Pouya Sarvari, et al.
Published: (2023-05-01) -
Somatic Mutations in Core Spliceosome Components Promote Tumorigenesis and Generate an Exploitable Vulnerability in Human Cancer
by: Claudio Sette, et al.
Published: (2022-04-01) -
A Quality Control Mechanism of Splice Site Selection Abrogated under Stress and in Cancer
by: Maram Arafat, et al.
Published: (2022-03-01) -
SF3B1 mutations in myelodysplastic syndromes: A potential therapeutic target for modulating the entire disease process
by: Moqin Jiang, et al.
Published: (2023-03-01)