Tuberculosis in a Portuguese Cohort
Background: Tuberculosis (TB) is a multisystemic disease and a leading cause of infectious disease-related mortality worldwide. Objectives: This study aims to characterize patients with TB in a portuguese cohort. Methods: Retrospective analysis of files pertaining inpatients with TB admitted betwe...
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| Format: | Article |
| Language: | English |
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Sociedade Galega de Medicina Interna
2017-06-01
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| Series: | Galicia Clínica |
| Subjects: | |
| Online Access: | http://www.galiciaclinica.info/publicacion.asp?f=997 |
| _version_ | 1819116665743343616 |
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| author | António Guerra-Maio Daniel Coutinho Sofia Nunes Jorge Velez Filomena Oliveira Célia Oliveira |
| author_facet | António Guerra-Maio Daniel Coutinho Sofia Nunes Jorge Velez Filomena Oliveira Célia Oliveira |
| author_sort | António Guerra-Maio |
| collection | DOAJ |
| description | Background: Tuberculosis (TB) is a multisystemic disease and a leading cause of infectious disease-related mortality worldwide.
Objectives: This study aims to characterize patients with TB in a portuguese cohort.
Methods: Retrospective analysis of files pertaining inpatients with TB admitted between 1/2005 - 12/2014. Data were analysed using χ2 or Fisher exact test (p<0.005 = statistically significant) and odds ratio was calculated.
Results: 222 cases were found: 128 patients had pulmonary involvement (PTB) and 100 extrapulmonary disease (ETB) (6 had overlapping disease), with men being mostly affected. The most common locations of ETB were lymphatic (27.0%), meningeal and osteoarticular (both 19.0%).
The majority exhibited risk factors (64.0%, p<0.005). PTB was associated with smoking (p=0.000, OR=5.05) and contact with TB-infected person (p=0.002, OR=7.53). HIV infection (p=0.000, OR=5.16) and age > 65 (p=0.005, OR=3.34) were associated with ETB.
48 patients were HIV-infected, with median CD4 count of 74.5 cells/µL (13-136), most cases occurring in the setting of new HIV diagnosis. HIV infection was statistically associated with disseminated (OR=12.64), pleural (OR=8.50), meningeal (OR=2.96) and lymphatic TB (OR=2.38). HIV negativity was associated with pulmonary (OR=4.08) and osteoarticular disease (OR=5.42).
PTB was confirmed mainly by culture or PCR test plus smear (81.3%). ETB diagnosis was more complex.
Clinical outcome was favourable (PTB 98.4%; ETB 94.0%). Eight patients died.
Conclusions: TB remains an important healthcare issue in Portugal. Contact with TB-infected person and smoking (PTB) and HIV infection and age > 65 (ETB), were significant risk factors. HIV infection was associated with disseminated, pleural, meningeal and lymphatic disease. |
| first_indexed | 2024-12-22T05:20:42Z |
| format | Article |
| id | doaj.art-7e2e2eb06c814e329806c083f4174636 |
| institution | Directory Open Access Journal |
| issn | 0304-4866 1989-3922 |
| language | English |
| last_indexed | 2024-12-22T05:20:42Z |
| publishDate | 2017-06-01 |
| publisher | Sociedade Galega de Medicina Interna |
| record_format | Article |
| series | Galicia Clínica |
| spelling | doaj.art-7e2e2eb06c814e329806c083f41746362022-12-21T18:37:44ZengSociedade Galega de Medicina InternaGalicia Clínica0304-48661989-39222017-06-01782657210.22546/44/997997Tuberculosis in a Portuguese CohortAntónio Guerra-Maio0Daniel Coutinho1Sofia Nunes2Jorge Velez3Filomena Oliveira4Célia Oliveira5Centro Hospitalar do Baixo Vouga, E.P.E.Centro Hospitalar do Baixo Vouga, E.P.E.Centro Hospitalar do Baixo Vouga, E.P.E.Centro Hospitalar do Baixo Vouga, E.P.E.Centro Hospitalar do Baixo Vouga, E.P.E.Centro Hospitalar do Baixo Vouga, E.P.E.Background: Tuberculosis (TB) is a multisystemic disease and a leading cause of infectious disease-related mortality worldwide. Objectives: This study aims to characterize patients with TB in a portuguese cohort. Methods: Retrospective analysis of files pertaining inpatients with TB admitted between 1/2005 - 12/2014. Data were analysed using χ2 or Fisher exact test (p<0.005 = statistically significant) and odds ratio was calculated. Results: 222 cases were found: 128 patients had pulmonary involvement (PTB) and 100 extrapulmonary disease (ETB) (6 had overlapping disease), with men being mostly affected. The most common locations of ETB were lymphatic (27.0%), meningeal and osteoarticular (both 19.0%). The majority exhibited risk factors (64.0%, p<0.005). PTB was associated with smoking (p=0.000, OR=5.05) and contact with TB-infected person (p=0.002, OR=7.53). HIV infection (p=0.000, OR=5.16) and age > 65 (p=0.005, OR=3.34) were associated with ETB. 48 patients were HIV-infected, with median CD4 count of 74.5 cells/µL (13-136), most cases occurring in the setting of new HIV diagnosis. HIV infection was statistically associated with disseminated (OR=12.64), pleural (OR=8.50), meningeal (OR=2.96) and lymphatic TB (OR=2.38). HIV negativity was associated with pulmonary (OR=4.08) and osteoarticular disease (OR=5.42). PTB was confirmed mainly by culture or PCR test plus smear (81.3%). ETB diagnosis was more complex. Clinical outcome was favourable (PTB 98.4%; ETB 94.0%). Eight patients died. Conclusions: TB remains an important healthcare issue in Portugal. Contact with TB-infected person and smoking (PTB) and HIV infection and age > 65 (ETB), were significant risk factors. HIV infection was associated with disseminated, pleural, meningeal and lymphatic disease.http://www.galiciaclinica.info/publicacion.asp?f=997TuberculosisExtrapulmonaresPulmonaresVIHFactores de riesgo |
| spellingShingle | António Guerra-Maio Daniel Coutinho Sofia Nunes Jorge Velez Filomena Oliveira Célia Oliveira Tuberculosis in a Portuguese Cohort Galicia Clínica Tuberculosis Extrapulmonares Pulmonares VIH Factores de riesgo |
| title | Tuberculosis in a Portuguese Cohort |
| title_full | Tuberculosis in a Portuguese Cohort |
| title_fullStr | Tuberculosis in a Portuguese Cohort |
| title_full_unstemmed | Tuberculosis in a Portuguese Cohort |
| title_short | Tuberculosis in a Portuguese Cohort |
| title_sort | tuberculosis in a portuguese cohort |
| topic | Tuberculosis Extrapulmonares Pulmonares VIH Factores de riesgo |
| url | http://www.galiciaclinica.info/publicacion.asp?f=997 |
| work_keys_str_mv | AT antonioguerramaio tuberculosisinaportuguesecohort AT danielcoutinho tuberculosisinaportuguesecohort AT sofianunes tuberculosisinaportuguesecohort AT jorgevelez tuberculosisinaportuguesecohort AT filomenaoliveira tuberculosisinaportuguesecohort AT celiaoliveira tuberculosisinaportuguesecohort |