Understanding the Elements of Maternal Protection from Systemic Bacterial Infections during Early Life
Late-onset sepsis (LOS) and other systemic bloodstream infections are notable causes of neonatal mortality, particularly in prematurely born very low birth weight infants. Breastfeeding in early life has numerous health benefits, impacting the health of the newborn in both the short-term and in the...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/12/4/1045 |
| _version_ | 1797570970756579328 |
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| author | Sierra A. Kleist Kathryn A. Knoop |
| author_facet | Sierra A. Kleist Kathryn A. Knoop |
| author_sort | Sierra A. Kleist |
| collection | DOAJ |
| description | Late-onset sepsis (LOS) and other systemic bloodstream infections are notable causes of neonatal mortality, particularly in prematurely born very low birth weight infants. Breastfeeding in early life has numerous health benefits, impacting the health of the newborn in both the short-term and in the long-term. Though the known benefits of an exclusive mother’s own milk diet in early life have been well recognized and described, it is less understood how breastfed infants enjoy a potential reduction in risk of LOS and other systemic infections. Here we review how gut residing pathogens within the intestinal microbiota of infants can cause a subset of sepsis cases and the components of breastmilk that may prevent the dissemination of pathogens from the intestine. |
| first_indexed | 2024-03-10T20:33:01Z |
| format | Article |
| id | doaj.art-7e2e7370689f4890a347d128536b4afc |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T20:33:01Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-7e2e7370689f4890a347d128536b4afc2023-11-19T21:15:05ZengMDPI AGNutrients2072-66432020-04-01124104510.3390/nu12041045Understanding the Elements of Maternal Protection from Systemic Bacterial Infections during Early LifeSierra A. Kleist0Kathryn A. Knoop1Department of Immunology, Mayo Clinic, Rochester, MN 55905, USADepartment of Immunology, Mayo Clinic, Rochester, MN 55905, USALate-onset sepsis (LOS) and other systemic bloodstream infections are notable causes of neonatal mortality, particularly in prematurely born very low birth weight infants. Breastfeeding in early life has numerous health benefits, impacting the health of the newborn in both the short-term and in the long-term. Though the known benefits of an exclusive mother’s own milk diet in early life have been well recognized and described, it is less understood how breastfed infants enjoy a potential reduction in risk of LOS and other systemic infections. Here we review how gut residing pathogens within the intestinal microbiota of infants can cause a subset of sepsis cases and the components of breastmilk that may prevent the dissemination of pathogens from the intestine.https://www.mdpi.com/2072-6643/12/4/1045breastmilklate onset sepsisbloodstream infectionsenteric pathogens |
| spellingShingle | Sierra A. Kleist Kathryn A. Knoop Understanding the Elements of Maternal Protection from Systemic Bacterial Infections during Early Life Nutrients breastmilk late onset sepsis bloodstream infections enteric pathogens |
| title | Understanding the Elements of Maternal Protection from Systemic Bacterial Infections during Early Life |
| title_full | Understanding the Elements of Maternal Protection from Systemic Bacterial Infections during Early Life |
| title_fullStr | Understanding the Elements of Maternal Protection from Systemic Bacterial Infections during Early Life |
| title_full_unstemmed | Understanding the Elements of Maternal Protection from Systemic Bacterial Infections during Early Life |
| title_short | Understanding the Elements of Maternal Protection from Systemic Bacterial Infections during Early Life |
| title_sort | understanding the elements of maternal protection from systemic bacterial infections during early life |
| topic | breastmilk late onset sepsis bloodstream infections enteric pathogens |
| url | https://www.mdpi.com/2072-6643/12/4/1045 |
| work_keys_str_mv | AT sierraakleist understandingtheelementsofmaternalprotectionfromsystemicbacterialinfectionsduringearlylife AT kathrynaknoop understandingtheelementsofmaternalprotectionfromsystemicbacterialinfectionsduringearlylife |