Monocarboxylate Transporters 1 and 4 and MTCO1 in Gastric Cancer
<i>Background:</i> Monocarboxylate transporters (MCTs) appear to play an important role in tumor development and aggressiveness. The present study aimed to evaluate associations between cytoplasmic MCT1, MCT4, and mitochondrial cytochrome c oxidase (MTCO1) expression and clinicopathologi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/9/2142 |
| _version_ | 1797535852656590848 |
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| author | Maarit Eskuri Niko Kemi Joonas H. Kauppila |
| author_facet | Maarit Eskuri Niko Kemi Joonas H. Kauppila |
| author_sort | Maarit Eskuri |
| collection | DOAJ |
| description | <i>Background:</i> Monocarboxylate transporters (MCTs) appear to play an important role in tumor development and aggressiveness. The present study aimed to evaluate associations between cytoplasmic MCT1, MCT4, and mitochondrial cytochrome c oxidase (MTCO1) expression and clinicopathological variables or survival in gastric cancer. <i>Material and methods</i>: A total of 568 gastric adenocarcinoma patients were included in this retrospective cohort study. Protein expressions were detected by immunohistochemical staining. The patients were divided into low expression and high expression groups by median value. The Chi-squared test was used to compare categorical variables. The T-test was used to compare continuous variables. Expressions were analyzed in relation to 5-year survival and overall survival. Cox regression provided HRs and 95% CIs, adjusted for confounders. <i>Results:</i> High cytoplasmic MCT1 expression was associated statistically significantly with higher T-class (<i>p</i> = 0.020). High cytoplasmic MCT4 expression was associated statistically significantly with positive lymph node status (<i>p</i> = 0.005) and was more common in Lauren’s intestinal type (<i>p</i> < 0.001). Low cytoplasmic MTCO1 expression was associated statistically significantly with positive distant metastases (<i>p</i> = 0.030), and high cytoplasmic MTCO1 expression was associated more often with intestinal type (<i>p</i> = 0.044). However, MCT1, MCT4, and MTCO1 were not associated with survival. <i>Conclusions:</i> Monocarboxylate receptors seem to be associated with gastric cancer progression but have no independent prognostic relevance. |
| first_indexed | 2024-03-10T11:50:13Z |
| format | Article |
| id | doaj.art-7e30105fe04b44f9b2e269145f1efb2c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T11:50:13Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-7e30105fe04b44f9b2e269145f1efb2c2023-11-21T17:44:03ZengMDPI AGCancers2072-66942021-04-01139214210.3390/cancers13092142Monocarboxylate Transporters 1 and 4 and MTCO1 in Gastric CancerMaarit Eskuri0Niko Kemi1Joonas H. Kauppila2Cancer and Translational Medicine Research Unit, Medical Research Center, University of Oulu and Oulu University Hospital, 90014 Oulu, FinlandCancer and Translational Medicine Research Unit, Medical Research Center, University of Oulu and Oulu University Hospital, 90014 Oulu, FinlandSurgery Research Unit, Medical Research Center, University of Oulu and Oulu University Hospital, 90014 Oulu, Finland<i>Background:</i> Monocarboxylate transporters (MCTs) appear to play an important role in tumor development and aggressiveness. The present study aimed to evaluate associations between cytoplasmic MCT1, MCT4, and mitochondrial cytochrome c oxidase (MTCO1) expression and clinicopathological variables or survival in gastric cancer. <i>Material and methods</i>: A total of 568 gastric adenocarcinoma patients were included in this retrospective cohort study. Protein expressions were detected by immunohistochemical staining. The patients were divided into low expression and high expression groups by median value. The Chi-squared test was used to compare categorical variables. The T-test was used to compare continuous variables. Expressions were analyzed in relation to 5-year survival and overall survival. Cox regression provided HRs and 95% CIs, adjusted for confounders. <i>Results:</i> High cytoplasmic MCT1 expression was associated statistically significantly with higher T-class (<i>p</i> = 0.020). High cytoplasmic MCT4 expression was associated statistically significantly with positive lymph node status (<i>p</i> = 0.005) and was more common in Lauren’s intestinal type (<i>p</i> < 0.001). Low cytoplasmic MTCO1 expression was associated statistically significantly with positive distant metastases (<i>p</i> = 0.030), and high cytoplasmic MTCO1 expression was associated more often with intestinal type (<i>p</i> = 0.044). However, MCT1, MCT4, and MTCO1 were not associated with survival. <i>Conclusions:</i> Monocarboxylate receptors seem to be associated with gastric cancer progression but have no independent prognostic relevance.https://www.mdpi.com/2072-6694/13/9/2142monocarboxylate transporterMTCO1gastric cancerimmunohistochemistry |
| spellingShingle | Maarit Eskuri Niko Kemi Joonas H. Kauppila Monocarboxylate Transporters 1 and 4 and MTCO1 in Gastric Cancer Cancers monocarboxylate transporter MTCO1 gastric cancer immunohistochemistry |
| title | Monocarboxylate Transporters 1 and 4 and MTCO1 in Gastric Cancer |
| title_full | Monocarboxylate Transporters 1 and 4 and MTCO1 in Gastric Cancer |
| title_fullStr | Monocarboxylate Transporters 1 and 4 and MTCO1 in Gastric Cancer |
| title_full_unstemmed | Monocarboxylate Transporters 1 and 4 and MTCO1 in Gastric Cancer |
| title_short | Monocarboxylate Transporters 1 and 4 and MTCO1 in Gastric Cancer |
| title_sort | monocarboxylate transporters 1 and 4 and mtco1 in gastric cancer |
| topic | monocarboxylate transporter MTCO1 gastric cancer immunohistochemistry |
| url | https://www.mdpi.com/2072-6694/13/9/2142 |
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