Association between HLA‐B and HLA‐DRB1 polymorphisms and systemic lupus erythematosus in Han population in China
Abstract We explored the association between HLA‐B and HLA‐DRB1 polymorphisms and reviewed clinical characteristics of systemic lupus erythematosus (SLE) in Han population in Yunnan, China. Methods There were 295 patients and 265 healthy control subjects (HCs) enrolled in the study. Clinical data an...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-03-01
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| Series: | Rheumatology & Autoimmunity |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rai2.12023 |
| _version_ | 1811274040659148800 |
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| author | Xiangyu Wang Yifan Yang Bibhuti Upreti Shuang Liu Ruomei Cui Yuqi Cheng Li Tao Jing Dong Luqiong Li Jian Xu |
| author_facet | Xiangyu Wang Yifan Yang Bibhuti Upreti Shuang Liu Ruomei Cui Yuqi Cheng Li Tao Jing Dong Luqiong Li Jian Xu |
| author_sort | Xiangyu Wang |
| collection | DOAJ |
| description | Abstract We explored the association between HLA‐B and HLA‐DRB1 polymorphisms and reviewed clinical characteristics of systemic lupus erythematosus (SLE) in Han population in Yunnan, China. Methods There were 295 patients and 265 healthy control subjects (HCs) enrolled in the study. Clinical data and blood samples were collected from the patients. The HLA‐B and HLA‐DRB1 genotypes were detected in SLE patients and HCs. Results A total of 74 genotypes on HLA‐B loci were determined in 288 patients as well as 57 genotypes in 265 HCs. The results showed SLE was associated with the HLA‐B*40:01 and HLA‐DRB1*08:03 alleles, and the HLA‐B*46:01, HLA‐DRB1*12:02, DRB1*04:03, DRB1*14:01, DRB1*04:06, and DRB1*11:01 alleles were less likely to appear in SLE patients. Additionally, HLA‐B*07:02 and B*40:06 were associated with disease activity. HLA‐DRB1*03:01, DRB1*13:02, and DRB1*12:01 were associated with proteinuria. Furthermore, HLA‐B*51:01, B*13:02, B*38:02, B*35:01, HLA‐DRB1*15:02, DRB1*15:04, DRB1*15:01, and DRB1*08:03 were correlated with inflammatory factors and immune dysfunction. HLA‐B*15:25 was related to the production of multiple antibodies. HLA‐DRB1*12:02 might be a protective factor for pancytopenia. The haplotype of HLA‐B*40:01/DRB1*08:03 was linked with SLE. Conclusion SLE in Han population in Yunnan province was associated with the HLA‐B*40:01 and HLA‐DRB1*08:03 alleles, and the haplotype HLA‐B*40:01/DRB1*08:03. Several alleles were associated with inflammation, immune disorders, and organ involvement in SLE. Those alleles might be potential genetic markers of SLE. |
| first_indexed | 2024-04-12T23:11:54Z |
| format | Article |
| id | doaj.art-7e3014f8332d46a1be70cc2d7d499f19 |
| institution | Directory Open Access Journal |
| issn | 2767-1429 |
| language | English |
| last_indexed | 2024-04-12T23:11:54Z |
| publishDate | 2022-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Rheumatology & Autoimmunity |
| spelling | doaj.art-7e3014f8332d46a1be70cc2d7d499f192022-12-22T03:12:47ZengWileyRheumatology & Autoimmunity2767-14292022-03-0121313910.1002/rai2.12023Association between HLA‐B and HLA‐DRB1 polymorphisms and systemic lupus erythematosus in Han population in ChinaXiangyu Wang0Yifan Yang1Bibhuti Upreti2Shuang Liu3Ruomei Cui4Yuqi Cheng5Li Tao6Jing Dong7Luqiong Li8Jian Xu9Department of Rheumatology and Immunology First Affiliated Hospital of Kunming Medical University Kunming Yunnan ChinaDepartment of Rheumatology and Immunology First Affiliated Hospital of Kunming Medical University Kunming Yunnan ChinaDepartment of Rheumatology and Immunology First Affiliated Hospital of Kunming Medical University Kunming Yunnan ChinaDepartment of Rheumatology and Immunology First Affiliated Hospital of Kunming Medical University Kunming Yunnan ChinaDepartment of Rheumatology and Immunology First Affiliated Hospital of Kunming Medical University Kunming Yunnan ChinaDepartment of Psychiatry First Affiliated Hospital of Kunming Medical University Kunming Yunnan ChinaDepartment of Rheumatology and Immunology First Affiliated Hospital of Kunming Medical University Kunming Yunnan ChinaDepartment of Rheumatology and Immunology First Affiliated Hospital of Kunming Medical University Kunming Yunnan ChinaDepartment of Rheumatology and Immunology First Affiliated Hospital of Kunming Medical University Kunming Yunnan ChinaDepartment of Rheumatology and Immunology First Affiliated Hospital of Kunming Medical University Kunming Yunnan ChinaAbstract We explored the association between HLA‐B and HLA‐DRB1 polymorphisms and reviewed clinical characteristics of systemic lupus erythematosus (SLE) in Han population in Yunnan, China. Methods There were 295 patients and 265 healthy control subjects (HCs) enrolled in the study. Clinical data and blood samples were collected from the patients. The HLA‐B and HLA‐DRB1 genotypes were detected in SLE patients and HCs. Results A total of 74 genotypes on HLA‐B loci were determined in 288 patients as well as 57 genotypes in 265 HCs. The results showed SLE was associated with the HLA‐B*40:01 and HLA‐DRB1*08:03 alleles, and the HLA‐B*46:01, HLA‐DRB1*12:02, DRB1*04:03, DRB1*14:01, DRB1*04:06, and DRB1*11:01 alleles were less likely to appear in SLE patients. Additionally, HLA‐B*07:02 and B*40:06 were associated with disease activity. HLA‐DRB1*03:01, DRB1*13:02, and DRB1*12:01 were associated with proteinuria. Furthermore, HLA‐B*51:01, B*13:02, B*38:02, B*35:01, HLA‐DRB1*15:02, DRB1*15:04, DRB1*15:01, and DRB1*08:03 were correlated with inflammatory factors and immune dysfunction. HLA‐B*15:25 was related to the production of multiple antibodies. HLA‐DRB1*12:02 might be a protective factor for pancytopenia. The haplotype of HLA‐B*40:01/DRB1*08:03 was linked with SLE. Conclusion SLE in Han population in Yunnan province was associated with the HLA‐B*40:01 and HLA‐DRB1*08:03 alleles, and the haplotype HLA‐B*40:01/DRB1*08:03. Several alleles were associated with inflammation, immune disorders, and organ involvement in SLE. Those alleles might be potential genetic markers of SLE.https://doi.org/10.1002/rai2.12023genetic polymorphismHLA‐BHLA‐DRB1SLE |
| spellingShingle | Xiangyu Wang Yifan Yang Bibhuti Upreti Shuang Liu Ruomei Cui Yuqi Cheng Li Tao Jing Dong Luqiong Li Jian Xu Association between HLA‐B and HLA‐DRB1 polymorphisms and systemic lupus erythematosus in Han population in China Rheumatology & Autoimmunity genetic polymorphism HLA‐B HLA‐DRB1 SLE |
| title | Association between HLA‐B and HLA‐DRB1 polymorphisms and systemic lupus erythematosus in Han population in China |
| title_full | Association between HLA‐B and HLA‐DRB1 polymorphisms and systemic lupus erythematosus in Han population in China |
| title_fullStr | Association between HLA‐B and HLA‐DRB1 polymorphisms and systemic lupus erythematosus in Han population in China |
| title_full_unstemmed | Association between HLA‐B and HLA‐DRB1 polymorphisms and systemic lupus erythematosus in Han population in China |
| title_short | Association between HLA‐B and HLA‐DRB1 polymorphisms and systemic lupus erythematosus in Han population in China |
| title_sort | association between hla b and hla drb1 polymorphisms and systemic lupus erythematosus in han population in china |
| topic | genetic polymorphism HLA‐B HLA‐DRB1 SLE |
| url | https://doi.org/10.1002/rai2.12023 |
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