Applications of macrocyclic molecules in cancer therapy: Target cancer development or overcome drug resistance
Abstract Cancer is a worldwide leading cause of cancer‐related death due to a lack of efficient disease control by drugs. With the increasing unmet needs in cancer treatment, developing novel effective cancer drugs is in great demand. Macrocyclic molecules represent a group of drug molecules with a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-09-01
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| Series: | MedComm – Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mog2.50 |
| _version_ | 1797672758428041216 |
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| author | Xiaoling Song Yifan Wu Xiaojuan Qu Biao Jiang |
| author_facet | Xiaoling Song Yifan Wu Xiaojuan Qu Biao Jiang |
| author_sort | Xiaoling Song |
| collection | DOAJ |
| description | Abstract Cancer is a worldwide leading cause of cancer‐related death due to a lack of efficient disease control by drugs. With the increasing unmet needs in cancer treatment, developing novel effective cancer drugs is in great demand. Macrocyclic molecules represent a group of drug molecules with a cyclic skeleton which endows them with unique drug properties such as improved bioavailability, enhanced metabolic stability, increased binding affinity, and favorable pharmacokinetics parameters. The Food and Drug Administration (FDA) has approved a bunch of macrocyclic drugs to treat cancer patients. However, the importance of such molecules in cancer drug development remains underestimated. Recent studies support that macrocyclic molecules can also serve as an effective strategy to overcome drug resistance in cancer treatment, but is a lack of review. The purpose of this manuscript was to provide shreds of evidence on the applications of macrocyclic molecules for cancer therapy: (1) act as cancer drugs to target different proteins critical for cancer development; (2) act as cancer drugs to target resistant mutants of oncogenes to overcome drug resistance in targeted therapy. This review will help to attract more interest in developing macrocyclic drugs for cancer therapy and potentially provide more novel strategies to benefit cancer patients and society. |
| first_indexed | 2024-03-11T21:34:53Z |
| format | Article |
| id | doaj.art-7e308bb49aeb46baa8710247d360e0b0 |
| institution | Directory Open Access Journal |
| issn | 2769-6448 |
| language | English |
| last_indexed | 2024-03-11T21:34:53Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm – Oncology |
| spelling | doaj.art-7e308bb49aeb46baa8710247d360e0b02023-09-27T04:32:33ZengWileyMedComm – Oncology2769-64482023-09-0123n/an/a10.1002/mog2.50Applications of macrocyclic molecules in cancer therapy: Target cancer development or overcome drug resistanceXiaoling Song0Yifan Wu1Xiaojuan Qu2Biao Jiang3Shanghai Institute for Advanced Immunochemical Studies ShanghaiTech University Shanghai People's Republic of ChinaShanghai Institute for Advanced Immunochemical Studies ShanghaiTech University Shanghai People's Republic of ChinaShanghai Institute for Advanced Immunochemical Studies ShanghaiTech University Shanghai People's Republic of ChinaShanghai Institute for Advanced Immunochemical Studies ShanghaiTech University Shanghai People's Republic of ChinaAbstract Cancer is a worldwide leading cause of cancer‐related death due to a lack of efficient disease control by drugs. With the increasing unmet needs in cancer treatment, developing novel effective cancer drugs is in great demand. Macrocyclic molecules represent a group of drug molecules with a cyclic skeleton which endows them with unique drug properties such as improved bioavailability, enhanced metabolic stability, increased binding affinity, and favorable pharmacokinetics parameters. The Food and Drug Administration (FDA) has approved a bunch of macrocyclic drugs to treat cancer patients. However, the importance of such molecules in cancer drug development remains underestimated. Recent studies support that macrocyclic molecules can also serve as an effective strategy to overcome drug resistance in cancer treatment, but is a lack of review. The purpose of this manuscript was to provide shreds of evidence on the applications of macrocyclic molecules for cancer therapy: (1) act as cancer drugs to target different proteins critical for cancer development; (2) act as cancer drugs to target resistant mutants of oncogenes to overcome drug resistance in targeted therapy. This review will help to attract more interest in developing macrocyclic drugs for cancer therapy and potentially provide more novel strategies to benefit cancer patients and society.https://doi.org/10.1002/mog2.50cancer therapydrug developmentdrug resistancemacrocyclic moleculestargeted therapy |
| spellingShingle | Xiaoling Song Yifan Wu Xiaojuan Qu Biao Jiang Applications of macrocyclic molecules in cancer therapy: Target cancer development or overcome drug resistance MedComm – Oncology cancer therapy drug development drug resistance macrocyclic molecules targeted therapy |
| title | Applications of macrocyclic molecules in cancer therapy: Target cancer development or overcome drug resistance |
| title_full | Applications of macrocyclic molecules in cancer therapy: Target cancer development or overcome drug resistance |
| title_fullStr | Applications of macrocyclic molecules in cancer therapy: Target cancer development or overcome drug resistance |
| title_full_unstemmed | Applications of macrocyclic molecules in cancer therapy: Target cancer development or overcome drug resistance |
| title_short | Applications of macrocyclic molecules in cancer therapy: Target cancer development or overcome drug resistance |
| title_sort | applications of macrocyclic molecules in cancer therapy target cancer development or overcome drug resistance |
| topic | cancer therapy drug development drug resistance macrocyclic molecules targeted therapy |
| url | https://doi.org/10.1002/mog2.50 |
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