Pharmacokinetic and pharmacodynamic principles: unique considerations for optimal design of neonatal clinical trials
Core clinical pharmacology principles must be considered when designing and executing neonatal clinical trials. In this review, the authors discuss important aspects of drug dose selection, pharmacokinetics, pharmacogenetics and pharmacodynamics that stakeholders may consider when undertaking a neon...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1345969/full |
| _version_ | 1797356958320164864 |
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| author | Cindy Hoi Ting Yeung Ruud H. J. Verstegen Ruud H. J. Verstegen Rachel Greenberg Rachel Greenberg Tamorah Rae Lewis Tamorah Rae Lewis |
| author_facet | Cindy Hoi Ting Yeung Ruud H. J. Verstegen Ruud H. J. Verstegen Rachel Greenberg Rachel Greenberg Tamorah Rae Lewis Tamorah Rae Lewis |
| author_sort | Cindy Hoi Ting Yeung |
| collection | DOAJ |
| description | Core clinical pharmacology principles must be considered when designing and executing neonatal clinical trials. In this review, the authors discuss important aspects of drug dose selection, pharmacokinetics, pharmacogenetics and pharmacodynamics that stakeholders may consider when undertaking a neonatal or infant clinical trial. |
| first_indexed | 2024-03-08T14:37:22Z |
| format | Article |
| id | doaj.art-7e30c107ec72423bbb03eab5cc6866a6 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-08T14:37:22Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-7e30c107ec72423bbb03eab5cc6866a62024-01-12T04:32:07ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602024-01-011110.3389/fped.2023.13459691345969Pharmacokinetic and pharmacodynamic principles: unique considerations for optimal design of neonatal clinical trialsCindy Hoi Ting Yeung0Ruud H. J. Verstegen1Ruud H. J. Verstegen2Rachel Greenberg3Rachel Greenberg4Tamorah Rae Lewis5Tamorah Rae Lewis6Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, ON, CanadaDivision of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, ON, CanadaDepartment of Pediatrics, University of Toronto, Toronto, ON, CanadaDuke Clinical Research Institute, Durham, NC, United StatesDepartment of Pediatrics, Duke University School of Medicine, Durham, NC, United StatesDivision of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, ON, CanadaDepartment of Pediatrics, University of Toronto, Toronto, ON, CanadaCore clinical pharmacology principles must be considered when designing and executing neonatal clinical trials. In this review, the authors discuss important aspects of drug dose selection, pharmacokinetics, pharmacogenetics and pharmacodynamics that stakeholders may consider when undertaking a neonatal or infant clinical trial.https://www.frontiersin.org/articles/10.3389/fped.2023.1345969/fullneonateclinical trialpharmacokineticpharmacogeneticdosepharmacodynamic |
| spellingShingle | Cindy Hoi Ting Yeung Ruud H. J. Verstegen Ruud H. J. Verstegen Rachel Greenberg Rachel Greenberg Tamorah Rae Lewis Tamorah Rae Lewis Pharmacokinetic and pharmacodynamic principles: unique considerations for optimal design of neonatal clinical trials Frontiers in Pediatrics neonate clinical trial pharmacokinetic pharmacogenetic dose pharmacodynamic |
| title | Pharmacokinetic and pharmacodynamic principles: unique considerations for optimal design of neonatal clinical trials |
| title_full | Pharmacokinetic and pharmacodynamic principles: unique considerations for optimal design of neonatal clinical trials |
| title_fullStr | Pharmacokinetic and pharmacodynamic principles: unique considerations for optimal design of neonatal clinical trials |
| title_full_unstemmed | Pharmacokinetic and pharmacodynamic principles: unique considerations for optimal design of neonatal clinical trials |
| title_short | Pharmacokinetic and pharmacodynamic principles: unique considerations for optimal design of neonatal clinical trials |
| title_sort | pharmacokinetic and pharmacodynamic principles unique considerations for optimal design of neonatal clinical trials |
| topic | neonate clinical trial pharmacokinetic pharmacogenetic dose pharmacodynamic |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1345969/full |
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