Pharmacokinetic and pharmacodynamic principles: unique considerations for optimal design of neonatal clinical trials

Pharmacokinetic and pharmacodynamic principles: unique considerations for optimal design of neonatal clinical trials

Core clinical pharmacology principles must be considered when designing and executing neonatal clinical trials. In this review, the authors discuss important aspects of drug dose selection, pharmacokinetics, pharmacogenetics and pharmacodynamics that stakeholders may consider when undertaking a neon...

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Bibliographic Details
Main Authors: Cindy Hoi Ting Yeung, Ruud H. J. Verstegen, Rachel Greenberg, Tamorah Rae Lewis
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Pediatrics
Subjects:
neonate
clinical trial
pharmacokinetic
pharmacogenetic
dose
pharmacodynamic
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2023.1345969/full

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