Programming Hippocampal Neural Stem/Progenitor Cells into Oligodendrocytes Enhances Remyelination in the Adult Brain after Injury
Demyelinating diseases are characterized by a loss of oligodendrocytes leading to axonal degeneration and impaired brain function. Current strategies used for the treatment of demyelinating disease such as multiple sclerosis largely rely on modulation of the immune system. Only limited treatment opt...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-06-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124715005501 |
| _version_ | 1819030224794288128 |
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| author | Simon M.G. Braun Gregor-Alexander Pilz Raquel A.C. Machado Jonathan Moss Burkhard Becher Nicolas Toni Sebastian Jessberger |
| author_facet | Simon M.G. Braun Gregor-Alexander Pilz Raquel A.C. Machado Jonathan Moss Burkhard Becher Nicolas Toni Sebastian Jessberger |
| author_sort | Simon M.G. Braun |
| collection | DOAJ |
| description | Demyelinating diseases are characterized by a loss of oligodendrocytes leading to axonal degeneration and impaired brain function. Current strategies used for the treatment of demyelinating disease such as multiple sclerosis largely rely on modulation of the immune system. Only limited treatment options are available for treating the later stages of the disease, and these treatments require regenerative therapies to ameliorate the consequences of oligodendrocyte loss and axonal impairment. Directed differentiation of adult hippocampal neural stem/progenitor cells (NSPCs) into oligodendrocytes may represent an endogenous source of glial cells for cell-replacement strategies aiming to treat demyelinating disease. Here, we show that Ascl1-mediated conversion of hippocampal NSPCs into mature oligodendrocytes enhances remyelination in a diphtheria-toxin (DT)-inducible, genetic model for demyelination. These findings highlight the potential of targeting hippocampal NSPCs for the treatment of demyelinated lesions in the adult brain. |
| first_indexed | 2024-12-21T06:26:46Z |
| format | Article |
| id | doaj.art-7e3113b93f2e434ba60e41769232145c |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-21T06:26:46Z |
| publishDate | 2015-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-7e3113b93f2e434ba60e41769232145c2022-12-21T19:13:05ZengElsevierCell Reports2211-12472015-06-0111111679168510.1016/j.celrep.2015.05.024Programming Hippocampal Neural Stem/Progenitor Cells into Oligodendrocytes Enhances Remyelination in the Adult Brain after InjurySimon M.G. Braun0Gregor-Alexander Pilz1Raquel A.C. Machado2Jonathan Moss3Burkhard Becher4Nicolas Toni5Sebastian Jessberger6Brain Research Institute, Faculty of Medicine and Science, University of Zurich, 8057 Zurich, SwitzerlandBrain Research Institute, Faculty of Medicine and Science, University of Zurich, 8057 Zurich, SwitzerlandBrain Research Institute, Faculty of Medicine and Science, University of Zurich, 8057 Zurich, SwitzerlandDepartment of Fundamental Neurosciences, University of Lausanne, 1015 Lausanne, SwitzerlandNeuroscience Center Zurich, University of Zurich and ETH, 8057 Zurich, SwitzerlandDepartment of Fundamental Neurosciences, University of Lausanne, 1015 Lausanne, SwitzerlandBrain Research Institute, Faculty of Medicine and Science, University of Zurich, 8057 Zurich, SwitzerlandDemyelinating diseases are characterized by a loss of oligodendrocytes leading to axonal degeneration and impaired brain function. Current strategies used for the treatment of demyelinating disease such as multiple sclerosis largely rely on modulation of the immune system. Only limited treatment options are available for treating the later stages of the disease, and these treatments require regenerative therapies to ameliorate the consequences of oligodendrocyte loss and axonal impairment. Directed differentiation of adult hippocampal neural stem/progenitor cells (NSPCs) into oligodendrocytes may represent an endogenous source of glial cells for cell-replacement strategies aiming to treat demyelinating disease. Here, we show that Ascl1-mediated conversion of hippocampal NSPCs into mature oligodendrocytes enhances remyelination in a diphtheria-toxin (DT)-inducible, genetic model for demyelination. These findings highlight the potential of targeting hippocampal NSPCs for the treatment of demyelinated lesions in the adult brain.http://www.sciencedirect.com/science/article/pii/S2211124715005501 |
| spellingShingle | Simon M.G. Braun Gregor-Alexander Pilz Raquel A.C. Machado Jonathan Moss Burkhard Becher Nicolas Toni Sebastian Jessberger Programming Hippocampal Neural Stem/Progenitor Cells into Oligodendrocytes Enhances Remyelination in the Adult Brain after Injury Cell Reports |
| title | Programming Hippocampal Neural Stem/Progenitor Cells into Oligodendrocytes Enhances Remyelination in the Adult Brain after Injury |
| title_full | Programming Hippocampal Neural Stem/Progenitor Cells into Oligodendrocytes Enhances Remyelination in the Adult Brain after Injury |
| title_fullStr | Programming Hippocampal Neural Stem/Progenitor Cells into Oligodendrocytes Enhances Remyelination in the Adult Brain after Injury |
| title_full_unstemmed | Programming Hippocampal Neural Stem/Progenitor Cells into Oligodendrocytes Enhances Remyelination in the Adult Brain after Injury |
| title_short | Programming Hippocampal Neural Stem/Progenitor Cells into Oligodendrocytes Enhances Remyelination in the Adult Brain after Injury |
| title_sort | programming hippocampal neural stem progenitor cells into oligodendrocytes enhances remyelination in the adult brain after injury |
| url | http://www.sciencedirect.com/science/article/pii/S2211124715005501 |
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