Investigation of the therapeutic properties of the leaves of Eriobotrya japonica (Thunb.) Lindl.
Following previous studies that have confirmed the therapeutic potential of medicinal plants, scientists are now focusing on the potential of these medicinal plants in resolving issues associated with adverse drug reactions. Reports have been made on medicinal plants having fewer...
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| Format: | Article |
| Language: | English |
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Plovdiv University Press
2024-01-01
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| Series: | Journal of BioScience and Biotechnology |
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| Online Access: | https://editorial.uni-plovdiv.bg/index.php/JBB/article/view/482/342 |
| _version_ | 1797354021403492352 |
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| author | Tapiwa Makaza Oleen Machona Rumbidzai Mangoyi |
| author_facet | Tapiwa Makaza Oleen Machona Rumbidzai Mangoyi |
| author_sort | Tapiwa Makaza |
| collection | DOAJ |
| description | Following previous studies that have confirmed the therapeutic potential of medicinal plants, scientists are now focusing on the potential of these medicinal plants in resolving issues associated with adverse drug reactions. Reports have been made on medicinal plants having fewer adverse drug reactions than synthetic drugs though a few medicinal plants have been approved by the Food and Drug Administration for therapeutic uses. The main aim of this research was to investigate the therapeutic properties of the leaves of Eriobotrya japonica (Thunb.) Lindl. The leaf constituents of E. japonica were extracted and quantified using maceration methods. The therapeutic potential of these phytochemicals was then investigated focusing on the antioxidant, anti-inflammatory, and antibacterial properties. The antioxidant properties were investigated using a newly proposed method called the Nitrocellulose Permanganometry assay. The anti-inflammatory and antibacterial assays were investigated using the albumin denaturation assay and broth dilution technique respectively. Alkaloids, flavonoids, and saponins showed anti-inflammatory activity by inhibiting albumin denaturation, with alkaloids having the most anti-inflammatory activity as compared to flavonoids and saponins. The relative intensities representing antioxidant potential showed that tannins had the highest antioxidant potency compared to the other tested phytochemicals. All the phytochemicals showed antibacterial activity against Staphylococcus aureus with cardiac glycosides being the most potent. Thus, E. japonica proved to have therapeutic potential as all the phytochemicals obtained from this plant showed anti-inflammatory, antioxidant, and antibacterial activity. Toxicity studies are therefore required to recommend the use of E. japonica as a natural remedy. |
| first_indexed | 2024-03-08T13:39:19Z |
| format | Article |
| id | doaj.art-7e317071a3f0420ca0b57f97e739d3fc |
| institution | Directory Open Access Journal |
| issn | 1314-6238 1314-6246 |
| language | English |
| last_indexed | 2024-03-08T13:39:19Z |
| publishDate | 2024-01-01 |
| publisher | Plovdiv University Press |
| record_format | Article |
| series | Journal of BioScience and Biotechnology |
| spelling | doaj.art-7e317071a3f0420ca0b57f97e739d3fc2024-01-16T11:47:47ZengPlovdiv University PressJournal of BioScience and Biotechnology1314-62381314-62462024-01-0112295101Investigation of the therapeutic properties of the leaves of Eriobotrya japonica (Thunb.) Lindl.Tapiwa Makaza0Oleen Machona1Rumbidzai Mangoyi2Department of Biotechnology and Biochemistry, University of Zimbabwe, P.O. Box MP 167, Mt Pleasant, Harare, Zimbabwe.Department of Biotechnology and Biochemistry, University of Zimbabwe, P.O. Box MP 167, Mt Pleasant, Harare, Zimbabwe.Department of Biotechnology and Biochemistry, University of Zimbabwe, P.O. Box MP 167, Mt Pleasant, Harare, Zimbabwe.Following previous studies that have confirmed the therapeutic potential of medicinal plants, scientists are now focusing on the potential of these medicinal plants in resolving issues associated with adverse drug reactions. Reports have been made on medicinal plants having fewer adverse drug reactions than synthetic drugs though a few medicinal plants have been approved by the Food and Drug Administration for therapeutic uses. The main aim of this research was to investigate the therapeutic properties of the leaves of Eriobotrya japonica (Thunb.) Lindl. The leaf constituents of E. japonica were extracted and quantified using maceration methods. The therapeutic potential of these phytochemicals was then investigated focusing on the antioxidant, anti-inflammatory, and antibacterial properties. The antioxidant properties were investigated using a newly proposed method called the Nitrocellulose Permanganometry assay. The anti-inflammatory and antibacterial assays were investigated using the albumin denaturation assay and broth dilution technique respectively. Alkaloids, flavonoids, and saponins showed anti-inflammatory activity by inhibiting albumin denaturation, with alkaloids having the most anti-inflammatory activity as compared to flavonoids and saponins. The relative intensities representing antioxidant potential showed that tannins had the highest antioxidant potency compared to the other tested phytochemicals. All the phytochemicals showed antibacterial activity against Staphylococcus aureus with cardiac glycosides being the most potent. Thus, E. japonica proved to have therapeutic potential as all the phytochemicals obtained from this plant showed anti-inflammatory, antioxidant, and antibacterial activity. Toxicity studies are therefore required to recommend the use of E. japonica as a natural remedy. https://editorial.uni-plovdiv.bg/index.php/JBB/article/view/482/342eriobotrya japonicatherapeuticalkaloidsflavonoidssaponinscardiac glycosidestanninsanti-inflammatoryantibacterialantioxidant |
| spellingShingle | Tapiwa Makaza Oleen Machona Rumbidzai Mangoyi Investigation of the therapeutic properties of the leaves of Eriobotrya japonica (Thunb.) Lindl. Journal of BioScience and Biotechnology eriobotrya japonica therapeutic alkaloids flavonoids saponins cardiac glycosides tannins anti-inflammatory antibacterial antioxidant |
| title | Investigation of the therapeutic properties of the leaves of Eriobotrya japonica (Thunb.) Lindl. |
| title_full | Investigation of the therapeutic properties of the leaves of Eriobotrya japonica (Thunb.) Lindl. |
| title_fullStr | Investigation of the therapeutic properties of the leaves of Eriobotrya japonica (Thunb.) Lindl. |
| title_full_unstemmed | Investigation of the therapeutic properties of the leaves of Eriobotrya japonica (Thunb.) Lindl. |
| title_short | Investigation of the therapeutic properties of the leaves of Eriobotrya japonica (Thunb.) Lindl. |
| title_sort | investigation of the therapeutic properties of the leaves of eriobotrya japonica thunb lindl |
| topic | eriobotrya japonica therapeutic alkaloids flavonoids saponins cardiac glycosides tannins anti-inflammatory antibacterial antioxidant |
| url | https://editorial.uni-plovdiv.bg/index.php/JBB/article/view/482/342 |
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