Association between bronchopulmonary dysplasia and early respiratory morbidity in children with respiratory distress syndrome: a case–control study using nationwide data
Abstract Bronchopulmonary dysplasia (BPD) can cause respiratory morbidity beyond the neonatal period. We aimed to analyze the association of BPD on childhood lower respiratory illness (LRI) and asthma among patients diagnosed with respiratory distress syndrome (RDS). This case–control study analyzed...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-11657-z |
| _version_ | 1811253253112856576 |
|---|---|
| author | Jeong Eun Shin Haerin Jang Jung Ho Han Joonsik Park Soo Yeon Kim Yoon Hee Kim Ho Seon Eun Soon Min Lee Kook In Park Myung Hyun Sohn Min Soo Park Kyung Won Kim |
| author_facet | Jeong Eun Shin Haerin Jang Jung Ho Han Joonsik Park Soo Yeon Kim Yoon Hee Kim Ho Seon Eun Soon Min Lee Kook In Park Myung Hyun Sohn Min Soo Park Kyung Won Kim |
| author_sort | Jeong Eun Shin |
| collection | DOAJ |
| description | Abstract Bronchopulmonary dysplasia (BPD) can cause respiratory morbidity beyond the neonatal period. We aimed to analyze the association of BPD on childhood lower respiratory illness (LRI) and asthma among patients diagnosed with respiratory distress syndrome (RDS). This case–control study analyzed data between 2002 and 2015 from a nationwide database. We included 55,066 children with RDS. Two-year LRI and asthma at ages 3 and 5 were assessed. Readmission for LRIs within 2 years of birth occurred in 53.9% and 37.9% of the BPD (n = 9470) and non-BPD (n = 45,596) cases, respectively. In the BPD group, the median number of hospitalizations, mechanical ventilation and oxygen use rates were significantly higher, while the hospitalization duration was significantly longer (P < 0.001 for all). The relative risk of BPD was 1.42 (1.39–1.45) on total readmission and 6.53 (5.96–7.15) on intensive care unit readmission. Asthma prevalence was significantly higher in BPD group (57.6% vs. 48.9% at age 3 and 44.3% vs. 38.2% at age 5, P < 0.001). In children with RDS, BPD could affect repetitive and worse LRI as an independent risk factor for respiratory morbidity during the first 2 years of life. BPD may also be a crucial risk factor for asthma in preschoolers. |
| first_indexed | 2024-04-12T16:48:10Z |
| format | Article |
| id | doaj.art-7e378a84273a4f468f8c516ce97c7b21 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T16:48:10Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-7e378a84273a4f468f8c516ce97c7b212022-12-22T03:24:31ZengNature PortfolioScientific Reports2045-23222022-05-011211810.1038/s41598-022-11657-zAssociation between bronchopulmonary dysplasia and early respiratory morbidity in children with respiratory distress syndrome: a case–control study using nationwide dataJeong Eun Shin0Haerin Jang1Jung Ho Han2Joonsik Park3Soo Yeon Kim4Yoon Hee Kim5Ho Seon Eun6Soon Min Lee7Kook In Park8Myung Hyun Sohn9Min Soo Park10Kyung Won Kim11Department of Pediatrics, Yonsei University College of MedicineDepartment of Pediatrics, Yonsei University College of MedicineDepartment of Pediatrics, Yonsei University College of MedicineDepartment of Pediatrics, Yonsei University College of MedicineDepartment of Pediatrics, Yonsei University College of MedicineDepartment of Pediatrics, Yonsei University College of MedicineDepartment of Pediatrics, Yonsei University College of MedicineDepartment of Pediatrics, Yonsei University College of MedicineDepartment of Pediatrics, Yonsei University College of MedicineDepartment of Pediatrics, Yonsei University College of MedicineDepartment of Pediatrics, Yonsei University College of MedicineDepartment of Pediatrics, Yonsei University College of MedicineAbstract Bronchopulmonary dysplasia (BPD) can cause respiratory morbidity beyond the neonatal period. We aimed to analyze the association of BPD on childhood lower respiratory illness (LRI) and asthma among patients diagnosed with respiratory distress syndrome (RDS). This case–control study analyzed data between 2002 and 2015 from a nationwide database. We included 55,066 children with RDS. Two-year LRI and asthma at ages 3 and 5 were assessed. Readmission for LRIs within 2 years of birth occurred in 53.9% and 37.9% of the BPD (n = 9470) and non-BPD (n = 45,596) cases, respectively. In the BPD group, the median number of hospitalizations, mechanical ventilation and oxygen use rates were significantly higher, while the hospitalization duration was significantly longer (P < 0.001 for all). The relative risk of BPD was 1.42 (1.39–1.45) on total readmission and 6.53 (5.96–7.15) on intensive care unit readmission. Asthma prevalence was significantly higher in BPD group (57.6% vs. 48.9% at age 3 and 44.3% vs. 38.2% at age 5, P < 0.001). In children with RDS, BPD could affect repetitive and worse LRI as an independent risk factor for respiratory morbidity during the first 2 years of life. BPD may also be a crucial risk factor for asthma in preschoolers.https://doi.org/10.1038/s41598-022-11657-z |
| spellingShingle | Jeong Eun Shin Haerin Jang Jung Ho Han Joonsik Park Soo Yeon Kim Yoon Hee Kim Ho Seon Eun Soon Min Lee Kook In Park Myung Hyun Sohn Min Soo Park Kyung Won Kim Association between bronchopulmonary dysplasia and early respiratory morbidity in children with respiratory distress syndrome: a case–control study using nationwide data Scientific Reports |
| title | Association between bronchopulmonary dysplasia and early respiratory morbidity in children with respiratory distress syndrome: a case–control study using nationwide data |
| title_full | Association between bronchopulmonary dysplasia and early respiratory morbidity in children with respiratory distress syndrome: a case–control study using nationwide data |
| title_fullStr | Association between bronchopulmonary dysplasia and early respiratory morbidity in children with respiratory distress syndrome: a case–control study using nationwide data |
| title_full_unstemmed | Association between bronchopulmonary dysplasia and early respiratory morbidity in children with respiratory distress syndrome: a case–control study using nationwide data |
| title_short | Association between bronchopulmonary dysplasia and early respiratory morbidity in children with respiratory distress syndrome: a case–control study using nationwide data |
| title_sort | association between bronchopulmonary dysplasia and early respiratory morbidity in children with respiratory distress syndrome a case control study using nationwide data |
| url | https://doi.org/10.1038/s41598-022-11657-z |
| work_keys_str_mv | AT jeongeunshin associationbetweenbronchopulmonarydysplasiaandearlyrespiratorymorbidityinchildrenwithrespiratorydistresssyndromeacasecontrolstudyusingnationwidedata AT haerinjang associationbetweenbronchopulmonarydysplasiaandearlyrespiratorymorbidityinchildrenwithrespiratorydistresssyndromeacasecontrolstudyusingnationwidedata AT junghohan associationbetweenbronchopulmonarydysplasiaandearlyrespiratorymorbidityinchildrenwithrespiratorydistresssyndromeacasecontrolstudyusingnationwidedata AT joonsikpark associationbetweenbronchopulmonarydysplasiaandearlyrespiratorymorbidityinchildrenwithrespiratorydistresssyndromeacasecontrolstudyusingnationwidedata AT sooyeonkim associationbetweenbronchopulmonarydysplasiaandearlyrespiratorymorbidityinchildrenwithrespiratorydistresssyndromeacasecontrolstudyusingnationwidedata AT yoonheekim associationbetweenbronchopulmonarydysplasiaandearlyrespiratorymorbidityinchildrenwithrespiratorydistresssyndromeacasecontrolstudyusingnationwidedata AT hoseoneun associationbetweenbronchopulmonarydysplasiaandearlyrespiratorymorbidityinchildrenwithrespiratorydistresssyndromeacasecontrolstudyusingnationwidedata AT soonminlee associationbetweenbronchopulmonarydysplasiaandearlyrespiratorymorbidityinchildrenwithrespiratorydistresssyndromeacasecontrolstudyusingnationwidedata AT kookinpark associationbetweenbronchopulmonarydysplasiaandearlyrespiratorymorbidityinchildrenwithrespiratorydistresssyndromeacasecontrolstudyusingnationwidedata AT myunghyunsohn associationbetweenbronchopulmonarydysplasiaandearlyrespiratorymorbidityinchildrenwithrespiratorydistresssyndromeacasecontrolstudyusingnationwidedata AT minsoopark associationbetweenbronchopulmonarydysplasiaandearlyrespiratorymorbidityinchildrenwithrespiratorydistresssyndromeacasecontrolstudyusingnationwidedata AT kyungwonkim associationbetweenbronchopulmonarydysplasiaandearlyrespiratorymorbidityinchildrenwithrespiratorydistresssyndromeacasecontrolstudyusingnationwidedata |