Polymorphism of genes of predisposition to cardiovascular diseases in population and prospective study
Analysis of polymorphism of genes of predisposition to cardiovascular diseases (CVD) in population and prospective study in Novosibirsk. Within the framework of the program MONICA is observed 7111 men and 5523 women from a unorganized population of Novosibirsk. For detection of the independent facto...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics
2007-12-01
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| Series: | Атеросклероз |
| Subjects: | |
| Online Access: | https://ateroskleroz.elpub.ru/jour/article/view/567/503 |
| _version_ | 1828073321977085952 |
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| author | M. I. Voevoda V. N. Maksimov S. K. Malujtina V. V. Gafarov S. V. Shishkin A. G. Romaschenko I. B. Kulikov S. N. Ustinov E. V. Shahtshneider V. P. Kobzev |
| author_facet | M. I. Voevoda V. N. Maksimov S. K. Malujtina V. V. Gafarov S. V. Shishkin A. G. Romaschenko I. B. Kulikov S. N. Ustinov E. V. Shahtshneider V. P. Kobzev |
| author_sort | M. I. Voevoda |
| collection | DOAJ |
| description | Analysis of polymorphism of genes of predisposition to cardiovascular diseases (CVD) in population and prospective study in Novosibirsk. Within the framework of the program MONICA is observed 7111 men and 5523 women from a unorganized population of Novosibirsk. For detection of the independent factors influential on risk of death from CVD, the multiple logistics regression analysis was conducted. On group of 838 men the association of polymorphism of genes - candidates CVD with the factors of risk, morbidity and death rate from CVD was studied. The data of epidemiological prospective study confirm independent influencing of a heritable predisposition on CVD on death rate from CVD in an opened population of Novosibirsk. The polymorphism of a gene FMS in man’s population sample is associated with an stroke (the data of prospective study) and with the factors of risk CVD in population research. I/D polymorphism of genes an ACE and A2b-adrenoreceptor is associated with CVD in a man’s population of Novosibirsk. The primary prevention of CVD should actuate a family history and polymorphism of genes - candidates, as the relevant factor for including of groups of risk. |
| first_indexed | 2024-04-11T01:26:09Z |
| format | Article |
| id | doaj.art-7e3c4daad76c4579a21b05b9181b8da0 |
| institution | Directory Open Access Journal |
| issn | 2078-256X |
| language | Russian |
| last_indexed | 2024-04-11T01:26:09Z |
| publishDate | 2007-12-01 |
| publisher | Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics |
| record_format | Article |
| series | Атеросклероз |
| spelling | doaj.art-7e3c4daad76c4579a21b05b9181b8da02023-01-03T10:17:07ZrusSiberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and GeneticsАтеросклероз2078-256X2007-12-01312428Polymorphism of genes of predisposition to cardiovascular diseases in population and prospective studyM. I. Voevoda0V. N. Maksimov1S. K. Malujtina2V. V. Gafarov3S. V. Shishkin4A. G. Romaschenko5I. B. Kulikov6S. N. Ustinov7E. V. Shahtshneider8V. P. Kobzev9RAMS Russian Federation SB RAMS Research Institute of Therapy NovosibirskRAMS Russian Federation SB RAMS Research Institute of Therapy NovosibirskRAMS Russian Federation SB RAMS Research Institute of Therapy NovosibirskRAMS Russian Federation SB RAMS Research Institute of Therapy NovosibirskRAMS Russian Federation SB RAMS Research Institute of Therapy NovosibirskRAS Russian Federation SB RAS Institute of Cytology and Genetics NovosibirskRAMS Russian Federation SB RAMS Research Institute of Therapy NovosibirskRAMS Russian Federation SB RAMS Research Institute of Therapy NovosibirskRAMS Russian Federation SB RAMS Research Institute of Therapy NovosibirskRAS Russian Federation SB RAS Institute of Cytology and Genetics NovosibirskAnalysis of polymorphism of genes of predisposition to cardiovascular diseases (CVD) in population and prospective study in Novosibirsk. Within the framework of the program MONICA is observed 7111 men and 5523 women from a unorganized population of Novosibirsk. For detection of the independent factors influential on risk of death from CVD, the multiple logistics regression analysis was conducted. On group of 838 men the association of polymorphism of genes - candidates CVD with the factors of risk, morbidity and death rate from CVD was studied. The data of epidemiological prospective study confirm independent influencing of a heritable predisposition on CVD on death rate from CVD in an opened population of Novosibirsk. The polymorphism of a gene FMS in man’s population sample is associated with an stroke (the data of prospective study) and with the factors of risk CVD in population research. I/D polymorphism of genes an ACE and A2b-adrenoreceptor is associated with CVD in a man’s population of Novosibirsk. The primary prevention of CVD should actuate a family history and polymorphism of genes - candidates, as the relevant factor for including of groups of risk.https://ateroskleroz.elpub.ru/jour/article/view/567/503epidemiologycoronary heart diseasefamily historypopulation studiespolymorphism of candidate genes |
| spellingShingle | M. I. Voevoda V. N. Maksimov S. K. Malujtina V. V. Gafarov S. V. Shishkin A. G. Romaschenko I. B. Kulikov S. N. Ustinov E. V. Shahtshneider V. P. Kobzev Polymorphism of genes of predisposition to cardiovascular diseases in population and prospective study Атеросклероз epidemiology coronary heart disease family history population studies polymorphism of candidate genes |
| title | Polymorphism of genes of predisposition to cardiovascular diseases in population and prospective study |
| title_full | Polymorphism of genes of predisposition to cardiovascular diseases in population and prospective study |
| title_fullStr | Polymorphism of genes of predisposition to cardiovascular diseases in population and prospective study |
| title_full_unstemmed | Polymorphism of genes of predisposition to cardiovascular diseases in population and prospective study |
| title_short | Polymorphism of genes of predisposition to cardiovascular diseases in population and prospective study |
| title_sort | polymorphism of genes of predisposition to cardiovascular diseases in population and prospective study |
| topic | epidemiology coronary heart disease family history population studies polymorphism of candidate genes |
| url | https://ateroskleroz.elpub.ru/jour/article/view/567/503 |
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