Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance
Abstract Lipids are essential constituents for malignant tumors, as they are absolutely required for tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by cancer cells themselves through activation of de novo synthesis pathways, they orchestrate a large variety of pro-tu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2022-08-01
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| Series: | Oncogenesis |
| Online Access: | https://doi.org/10.1038/s41389-022-00420-8 |
| _version_ | 1811215644290449408 |
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| author | Sophie Vasseur Fabienne Guillaumond |
| author_facet | Sophie Vasseur Fabienne Guillaumond |
| author_sort | Sophie Vasseur |
| collection | DOAJ |
| description | Abstract Lipids are essential constituents for malignant tumors, as they are absolutely required for tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by cancer cells themselves through activation of de novo synthesis pathways, they orchestrate a large variety of pro-tumorigenic functions. Importantly, TME cells, especially immune cells, cancer-associated fibroblasts (CAFs) and cancer-associated adipocytes (CAAs), are also prone to changes in their lipid content, which hinder or promote tumor aggressiveness. In this review, we address the significant findings for lipid contribution in tumor progression towards a metastatic disease and in the poor response to therapeutic treatments. We also highlight the benefits of targeting lipid pathways in preclinical models to slow down metastasis development and overcome chemo-and immunotherapy resistance. |
| first_indexed | 2024-04-12T06:26:04Z |
| format | Article |
| id | doaj.art-7e3d102706634a44b80250aa8187e0b4 |
| institution | Directory Open Access Journal |
| issn | 2157-9024 |
| language | English |
| last_indexed | 2024-04-12T06:26:04Z |
| publishDate | 2022-08-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Oncogenesis |
| spelling | doaj.art-7e3d102706634a44b80250aa8187e0b42022-12-22T03:44:09ZengNature Publishing GroupOncogenesis2157-90242022-08-0111111510.1038/s41389-022-00420-8Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistanceSophie Vasseur0Fabienne Guillaumond1Centre de Recherche en Cancérologie de Marseille, INSERM, Aix-Marseille Université, CNRS, Institut Paoli-CalmettesCentre de Recherche en Cancérologie de Marseille, INSERM, Aix-Marseille Université, CNRS, Institut Paoli-CalmettesAbstract Lipids are essential constituents for malignant tumors, as they are absolutely required for tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by cancer cells themselves through activation of de novo synthesis pathways, they orchestrate a large variety of pro-tumorigenic functions. Importantly, TME cells, especially immune cells, cancer-associated fibroblasts (CAFs) and cancer-associated adipocytes (CAAs), are also prone to changes in their lipid content, which hinder or promote tumor aggressiveness. In this review, we address the significant findings for lipid contribution in tumor progression towards a metastatic disease and in the poor response to therapeutic treatments. We also highlight the benefits of targeting lipid pathways in preclinical models to slow down metastasis development and overcome chemo-and immunotherapy resistance.https://doi.org/10.1038/s41389-022-00420-8 |
| spellingShingle | Sophie Vasseur Fabienne Guillaumond Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance Oncogenesis |
| title | Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance |
| title_full | Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance |
| title_fullStr | Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance |
| title_full_unstemmed | Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance |
| title_short | Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance |
| title_sort | lipids in cancer a global view of the contribution of lipid pathways to metastatic formation and treatment resistance |
| url | https://doi.org/10.1038/s41389-022-00420-8 |
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