Breastfeeding is not a risk factor for mother-to-child transmission of hepatitis B virus.
BACKGROUND: Many clinicians do not encourage breastfeeding in hepatitis B virus (HBV) carriers, since HBV DNA can be detected in breast milk and breast lesions may increase exposure of infants to HBV. The aim of this study was to determine whether breastfeeding may add risk for perinatal HBV transmi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3557270?pdf=render |
| _version_ | 1811338263918542848 |
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| author | Xiangru Chen Jie Chen Jian Wen Chenyu Xu Shu Zhang Yi-Hua Zhou Yali Hu |
| author_facet | Xiangru Chen Jie Chen Jian Wen Chenyu Xu Shu Zhang Yi-Hua Zhou Yali Hu |
| author_sort | Xiangru Chen |
| collection | DOAJ |
| description | BACKGROUND: Many clinicians do not encourage breastfeeding in hepatitis B virus (HBV) carriers, since HBV DNA can be detected in breast milk and breast lesions may increase exposure of infants to HBV. The aim of this study was to determine whether breastfeeding may add risk for perinatal HBV transmission. METHODOLOGY/PRINCIPAL FINDINGS: Totally 546 children (1-7-year-old) of 544 HBV-infected mothers were investigated, with 397 breastfed and 149 formula-fed; 137 were born to HBeAg-positive mothers. All children had been vaccinated against hepatitis B but only 53.3% received hepatitis B immune globulin (HBIG). The overall prevalence of HBsAg+, HBsAg-/anti-HBc+, and anti-HBs (≥10 mIU/ml) in children was 2.4%, 3.1%, and 71.6% respectively. The HBsAg prevalence in breast- and formula-fed children was 1.5% and 4.7% respectively (P = 0.063); the difference was likely due to the higher mothers' HBeAg-positive rate in formula-fed group (formula-fed 49.0% vs. breastfed 15.9%, P<0.001). Further logistic regression analyses showed that breastfeeding was not associated with the HBV infection in the children, adjusting for the effect of maternal HBeAg status and other factors different between the two groups. CONCLUSIONS/SIGNIFICANCE: Under the recommended prophylaxis, breastfeeding is not a risk factor for mother-to-child transmission of HBV. Therefore, clinicians should encourage HBV-infected mothers to breastfeed their infants. |
| first_indexed | 2024-04-13T18:08:23Z |
| format | Article |
| id | doaj.art-7e3d6efaca7742258a60d5ee67787b70 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T18:08:23Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7e3d6efaca7742258a60d5ee67787b702022-12-22T02:36:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0181e5530310.1371/journal.pone.0055303Breastfeeding is not a risk factor for mother-to-child transmission of hepatitis B virus.Xiangru ChenJie ChenJian WenChenyu XuShu ZhangYi-Hua ZhouYali HuBACKGROUND: Many clinicians do not encourage breastfeeding in hepatitis B virus (HBV) carriers, since HBV DNA can be detected in breast milk and breast lesions may increase exposure of infants to HBV. The aim of this study was to determine whether breastfeeding may add risk for perinatal HBV transmission. METHODOLOGY/PRINCIPAL FINDINGS: Totally 546 children (1-7-year-old) of 544 HBV-infected mothers were investigated, with 397 breastfed and 149 formula-fed; 137 were born to HBeAg-positive mothers. All children had been vaccinated against hepatitis B but only 53.3% received hepatitis B immune globulin (HBIG). The overall prevalence of HBsAg+, HBsAg-/anti-HBc+, and anti-HBs (≥10 mIU/ml) in children was 2.4%, 3.1%, and 71.6% respectively. The HBsAg prevalence in breast- and formula-fed children was 1.5% and 4.7% respectively (P = 0.063); the difference was likely due to the higher mothers' HBeAg-positive rate in formula-fed group (formula-fed 49.0% vs. breastfed 15.9%, P<0.001). Further logistic regression analyses showed that breastfeeding was not associated with the HBV infection in the children, adjusting for the effect of maternal HBeAg status and other factors different between the two groups. CONCLUSIONS/SIGNIFICANCE: Under the recommended prophylaxis, breastfeeding is not a risk factor for mother-to-child transmission of HBV. Therefore, clinicians should encourage HBV-infected mothers to breastfeed their infants.http://europepmc.org/articles/PMC3557270?pdf=render |
| spellingShingle | Xiangru Chen Jie Chen Jian Wen Chenyu Xu Shu Zhang Yi-Hua Zhou Yali Hu Breastfeeding is not a risk factor for mother-to-child transmission of hepatitis B virus. PLoS ONE |
| title | Breastfeeding is not a risk factor for mother-to-child transmission of hepatitis B virus. |
| title_full | Breastfeeding is not a risk factor for mother-to-child transmission of hepatitis B virus. |
| title_fullStr | Breastfeeding is not a risk factor for mother-to-child transmission of hepatitis B virus. |
| title_full_unstemmed | Breastfeeding is not a risk factor for mother-to-child transmission of hepatitis B virus. |
| title_short | Breastfeeding is not a risk factor for mother-to-child transmission of hepatitis B virus. |
| title_sort | breastfeeding is not a risk factor for mother to child transmission of hepatitis b virus |
| url | http://europepmc.org/articles/PMC3557270?pdf=render |
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