Application of injectable hydrogels in cancer immunotherapy
Immunotherapy is a revolutionary and promising approach to cancer treatment. However, traditional cancer immunotherapy often has the disadvantages of limited immune response rate, poor targeting, and low treatment index due to systemic administration. Hydrogels are drug carriers with many advantages...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-02-01
|
| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1121887/full |
| _version_ | 1811173250262106112 |
|---|---|
| author | Chutong Liu Yingying Liao Lei Liu Luoyijun Xie Junbo Liu Yumao Zhang Yuzhen Li |
| author_facet | Chutong Liu Yingying Liao Lei Liu Luoyijun Xie Junbo Liu Yumao Zhang Yuzhen Li |
| author_sort | Chutong Liu |
| collection | DOAJ |
| description | Immunotherapy is a revolutionary and promising approach to cancer treatment. However, traditional cancer immunotherapy often has the disadvantages of limited immune response rate, poor targeting, and low treatment index due to systemic administration. Hydrogels are drug carriers with many advantages. They can be loaded and transported with immunotherapeutic agents, chemical anticancer drugs, radiopharmaceuticals, photothermal agents, photosensitizers, and other therapeutic agents to achieve controlled release of drugs, extend the retention time of drugs, and thus successfully trigger anti-tumor effects and maintain long-term therapeutic effects after administration. This paper reviews recent advances in injectable hydrogel-based cancer immunotherapy, including immunotherapy alone, immunotherapy with combination chemotherapy, radiotherapy, phototherapy, and DNA hydrogel-based immunotherapy. Finally, we review the potential and limitations of injectable hydrogels in cancer immunotherapy. |
| first_indexed | 2024-04-10T17:44:20Z |
| format | Article |
| id | doaj.art-7e3de665cd58421a96e11728719c6cfd |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-10T17:44:20Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-7e3de665cd58421a96e11728719c6cfd2023-02-03T05:45:02ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-02-011110.3389/fbioe.2023.11218871121887Application of injectable hydrogels in cancer immunotherapyChutong LiuYingying LiaoLei LiuLuoyijun XieJunbo LiuYumao ZhangYuzhen LiImmunotherapy is a revolutionary and promising approach to cancer treatment. However, traditional cancer immunotherapy often has the disadvantages of limited immune response rate, poor targeting, and low treatment index due to systemic administration. Hydrogels are drug carriers with many advantages. They can be loaded and transported with immunotherapeutic agents, chemical anticancer drugs, radiopharmaceuticals, photothermal agents, photosensitizers, and other therapeutic agents to achieve controlled release of drugs, extend the retention time of drugs, and thus successfully trigger anti-tumor effects and maintain long-term therapeutic effects after administration. This paper reviews recent advances in injectable hydrogel-based cancer immunotherapy, including immunotherapy alone, immunotherapy with combination chemotherapy, radiotherapy, phototherapy, and DNA hydrogel-based immunotherapy. Finally, we review the potential and limitations of injectable hydrogels in cancer immunotherapy.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1121887/fullinjectable hydrogelcancer immunotherapydelivery systemchemotherapyradiotherapyphototherapy |
| spellingShingle | Chutong Liu Yingying Liao Lei Liu Luoyijun Xie Junbo Liu Yumao Zhang Yuzhen Li Application of injectable hydrogels in cancer immunotherapy Frontiers in Bioengineering and Biotechnology injectable hydrogel cancer immunotherapy delivery system chemotherapy radiotherapy phototherapy |
| title | Application of injectable hydrogels in cancer immunotherapy |
| title_full | Application of injectable hydrogels in cancer immunotherapy |
| title_fullStr | Application of injectable hydrogels in cancer immunotherapy |
| title_full_unstemmed | Application of injectable hydrogels in cancer immunotherapy |
| title_short | Application of injectable hydrogels in cancer immunotherapy |
| title_sort | application of injectable hydrogels in cancer immunotherapy |
| topic | injectable hydrogel cancer immunotherapy delivery system chemotherapy radiotherapy phototherapy |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1121887/full |
| work_keys_str_mv | AT chutongliu applicationofinjectablehydrogelsincancerimmunotherapy AT yingyingliao applicationofinjectablehydrogelsincancerimmunotherapy AT leiliu applicationofinjectablehydrogelsincancerimmunotherapy AT luoyijunxie applicationofinjectablehydrogelsincancerimmunotherapy AT junboliu applicationofinjectablehydrogelsincancerimmunotherapy AT yumaozhang applicationofinjectablehydrogelsincancerimmunotherapy AT yuzhenli applicationofinjectablehydrogelsincancerimmunotherapy |