Multidisciplinary management of adolescents and young adults (AYA) sarcoma: A successful effort of an adult high‐volume cancer center
Abstract Introduction The aim of this retrospective study was to investigate the clinicopathological characteristics of AYA sarcomas and their clinical outcomes at a high‐volume single center. Methods Demographic, clinicopathological data on the diagnosis, treatment and follow‐up of all sarcoma pati...
Main Authors: | , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
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Wiley
2023-08-01
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Series: | Cancer Medicine |
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Online Access: | https://doi.org/10.1002/cam4.6289 |
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author | Alexia Francesca Bertuzzi Maria Susanna Grimaudo Alice Laffi Laura Giordano Nicolò Gennaro Umberto Cariboni Licia Vanessa Siracusano Vittorio Quagliuolo Piergiuseppe Colombo D’Orazio Federico Salvatore Lorenzo Renne Cristina Specchia Ferdinando Cananzi Andrea Marrari Pierina Navarria Primo Andrea Daolio Stefano Bastoni Armando Santoro |
author_facet | Alexia Francesca Bertuzzi Maria Susanna Grimaudo Alice Laffi Laura Giordano Nicolò Gennaro Umberto Cariboni Licia Vanessa Siracusano Vittorio Quagliuolo Piergiuseppe Colombo D’Orazio Federico Salvatore Lorenzo Renne Cristina Specchia Ferdinando Cananzi Andrea Marrari Pierina Navarria Primo Andrea Daolio Stefano Bastoni Armando Santoro |
author_sort | Alexia Francesca Bertuzzi |
collection | DOAJ |
description | Abstract Introduction The aim of this retrospective study was to investigate the clinicopathological characteristics of AYA sarcomas and their clinical outcomes at a high‐volume single center. Methods Demographic, clinicopathological data on the diagnosis, treatment and follow‐up of all sarcoma patients aged 16–39 years (ys) observed at our Institute between January 2010 and December 2021 were retrospectively collected, including diagnostic (TTD) and treatment delay(TTT), clinical outcomes (OS and PFS), and late‐treatment effects. Results We identified 228 AYA patients, median age 30 years, 29% ≤ 25 years, 57% males, 88% soft tissue sarcomas (STS), and 12% bone sarcomas (BS). Among STSs, 13% were small round cell tumors (SRCT), 52% intermediate–high‐grade, 24% low‐grade STSs. Among BS, 32% were high‐grade. Median TTD and TTT were 120 (0–8255) and 7 days (0–83), respectively. Surgery was performed in 83%, radiotherapy in 29%, and systemic therapy in 27%. Median follow‐up was 72.9 months(1.6–145), 5‐year and 10‐year OS were 78.5% and 62%, respectively. Kaplan–Meyer analysis showed a significantly better 5‐year OS and PFS for patients with >92 days of TTD (OS 85.7% vs. 66.7%, p = 0.001, PFS 50.2% vs. 24.9%, p = 0.009). According to age (≤25 years vs. > 25 years), 5‐year OS was 69.8% versus 82.2%, respectively (p = 0.047). Conclusion Our analysis confirmed previous data on sarcoma AYA patients followed in a referral center. Unexpectedly, diagnostic delay was not associated with poor OS and PFS. Patients <25 years showed a poorer prognosis due to the higher incidence of SRCT. |
first_indexed | 2024-03-08T15:50:50Z |
format | Article |
id | doaj.art-7e41660ffae240f593090873594dd21e |
institution | Directory Open Access Journal |
issn | 2045-7634 |
language | English |
last_indexed | 2024-03-08T15:50:50Z |
publishDate | 2023-08-01 |
publisher | Wiley |
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series | Cancer Medicine |
spelling | doaj.art-7e41660ffae240f593090873594dd21e2024-01-09T05:41:08ZengWileyCancer Medicine2045-76342023-08-011215162541626310.1002/cam4.6289Multidisciplinary management of adolescents and young adults (AYA) sarcoma: A successful effort of an adult high‐volume cancer centerAlexia Francesca Bertuzzi0Maria Susanna Grimaudo1Alice Laffi2Laura Giordano3Nicolò Gennaro4Umberto Cariboni5Licia Vanessa Siracusano6Vittorio Quagliuolo7Piergiuseppe Colombo8D’Orazio Federico9Salvatore Lorenzo Renne10Cristina Specchia11Ferdinando Cananzi12Andrea Marrari13Pierina Navarria14Primo Andrea Daolio15Stefano Bastoni16Armando Santoro17Department of Oncology & Hematology IRCCS Humanitas Research Hospital Rozzano ItalyDepartment of Biomedical Sciences Humanitas University ItalyDepartment of Oncology & Hematology IRCCS Humanitas Research Hospital Rozzano ItalyBiostatistic Unit IRCCS Humanitas Research Hospital Rozzano ItalyFeinberg School of Medicine Northwestern University Chicago USADepartment of Surgery IRCCS Humanitas Research Hospital Rozzano ItalyDepartment of Oncology & Hematology IRCCS Humanitas Research Hospital Rozzano ItalyDepartment of Surgery IRCCS Humanitas Research Hospital Rozzano ItalyDepartment of Biomedical Sciences Humanitas University ItalyDepartment of Radiology IRCCS Humanitas Research Hospital Rozzano ItalyDepartment of Biomedical Sciences Humanitas University ItalyDepartment of Gynecology IRCCS Humanitas Research Hospital Rozzano ItalyDepartment of Biomedical Sciences Humanitas University ItalyDepartment of Oncology Istituto Ortopedico Rizzoli Bologna ItalyDepartment of Radiotherapy and Radiosurgery IRCCS Humanitas Research Hospital Rozzano ItalyDepartment of Orthopedics ASST‐Gaetano Pini‐CTO Milano ItalyDepartment of Orthopedics ASST‐Gaetano Pini‐CTO Milano ItalyDepartment of Oncology & Hematology IRCCS Humanitas Research Hospital Rozzano ItalyAbstract Introduction The aim of this retrospective study was to investigate the clinicopathological characteristics of AYA sarcomas and their clinical outcomes at a high‐volume single center. Methods Demographic, clinicopathological data on the diagnosis, treatment and follow‐up of all sarcoma patients aged 16–39 years (ys) observed at our Institute between January 2010 and December 2021 were retrospectively collected, including diagnostic (TTD) and treatment delay(TTT), clinical outcomes (OS and PFS), and late‐treatment effects. Results We identified 228 AYA patients, median age 30 years, 29% ≤ 25 years, 57% males, 88% soft tissue sarcomas (STS), and 12% bone sarcomas (BS). Among STSs, 13% were small round cell tumors (SRCT), 52% intermediate–high‐grade, 24% low‐grade STSs. Among BS, 32% were high‐grade. Median TTD and TTT were 120 (0–8255) and 7 days (0–83), respectively. Surgery was performed in 83%, radiotherapy in 29%, and systemic therapy in 27%. Median follow‐up was 72.9 months(1.6–145), 5‐year and 10‐year OS were 78.5% and 62%, respectively. Kaplan–Meyer analysis showed a significantly better 5‐year OS and PFS for patients with >92 days of TTD (OS 85.7% vs. 66.7%, p = 0.001, PFS 50.2% vs. 24.9%, p = 0.009). According to age (≤25 years vs. > 25 years), 5‐year OS was 69.8% versus 82.2%, respectively (p = 0.047). Conclusion Our analysis confirmed previous data on sarcoma AYA patients followed in a referral center. Unexpectedly, diagnostic delay was not associated with poor OS and PFS. Patients <25 years showed a poorer prognosis due to the higher incidence of SRCT.https://doi.org/10.1002/cam4.6289adolescentAYAoncologysarcomayoung adult |
spellingShingle | Alexia Francesca Bertuzzi Maria Susanna Grimaudo Alice Laffi Laura Giordano Nicolò Gennaro Umberto Cariboni Licia Vanessa Siracusano Vittorio Quagliuolo Piergiuseppe Colombo D’Orazio Federico Salvatore Lorenzo Renne Cristina Specchia Ferdinando Cananzi Andrea Marrari Pierina Navarria Primo Andrea Daolio Stefano Bastoni Armando Santoro Multidisciplinary management of adolescents and young adults (AYA) sarcoma: A successful effort of an adult high‐volume cancer center Cancer Medicine adolescent AYA oncology sarcoma young adult |
title | Multidisciplinary management of adolescents and young adults (AYA) sarcoma: A successful effort of an adult high‐volume cancer center |
title_full | Multidisciplinary management of adolescents and young adults (AYA) sarcoma: A successful effort of an adult high‐volume cancer center |
title_fullStr | Multidisciplinary management of adolescents and young adults (AYA) sarcoma: A successful effort of an adult high‐volume cancer center |
title_full_unstemmed | Multidisciplinary management of adolescents and young adults (AYA) sarcoma: A successful effort of an adult high‐volume cancer center |
title_short | Multidisciplinary management of adolescents and young adults (AYA) sarcoma: A successful effort of an adult high‐volume cancer center |
title_sort | multidisciplinary management of adolescents and young adults aya sarcoma a successful effort of an adult high volume cancer center |
topic | adolescent AYA oncology sarcoma young adult |
url | https://doi.org/10.1002/cam4.6289 |
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