Oral Administration of Platinum Nanoparticles with SOD/CAT Cascade Catalytic Activity to Alleviate Ulcerative Colitis
Ulcerative colitis (UC) is a refractory chronic inflammatory disease involving the colon and rectum, falling under the category of inflammatory bowel disease (IBD). The accumulation of reactive oxygen species (ROS) in local tissues has been identified as a crucial contributor to the escalation of in...
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MDPI AG
2023-11-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/14/11/548 |
| _version_ | 1797458782917230592 |
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| author | Hao Liu Yujie Zhang Mingzhen Zhang Zhaoxiang Yu Mingxin Zhang |
| author_facet | Hao Liu Yujie Zhang Mingzhen Zhang Zhaoxiang Yu Mingxin Zhang |
| author_sort | Hao Liu |
| collection | DOAJ |
| description | Ulcerative colitis (UC) is a refractory chronic inflammatory disease involving the colon and rectum, falling under the category of inflammatory bowel disease (IBD). The accumulation of reactive oxygen species (ROS) in local tissues has been identified as a crucial contributor to the escalation of inflammatory responses. Therefore, eliminating ROS in the inflamed colon is a promising approach to treating UC. Nanomaterials with intrinsic enzyme-like activities (nanozymes) have shown significant therapeutic potential in UC. In this study, we found that platinum nanoparticles (Pt NPs) exhibited remarkable superoxide dismutase (SOD) and catalase (CAT) cascade catalytic activities, as well as effective hydroxyl radical (•OH) scavenging ability. The in vitro experiments showed that Pt NPs could eliminate excessive ROS to protect cells against oxidative stress. In the colitis model, oral administration of Pt NPs (loaded in chitosan/alginate hydrogel) could significantly alleviate UC, including reducing the colon length, the damaged epithelium, and the infiltration of inflammatory cells. Without appreciable systemic toxicity, Pt NPs represent a novel therapeutic approach to UC and are expected to achieve long-term inflammatory remission. |
| first_indexed | 2024-03-09T16:43:06Z |
| format | Article |
| id | doaj.art-7e469b12cd944a30a3058bfe3e82ba61 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-09T16:43:06Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-7e469b12cd944a30a3058bfe3e82ba612023-11-24T14:50:00ZengMDPI AGJournal of Functional Biomaterials2079-49832023-11-01141154810.3390/jfb14110548Oral Administration of Platinum Nanoparticles with SOD/CAT Cascade Catalytic Activity to Alleviate Ulcerative ColitisHao Liu0Yujie Zhang1Mingzhen Zhang2Zhaoxiang Yu3Mingxin Zhang4Second Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang 712046, ChinaSchool of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an 710061, ChinaSchool of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an 710061, ChinaDepartment of General Surgery, The First Affiliated Hospital of Xi’an Medical University, Xi’an 710077, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Xi’an Medical University, Xi’an 710077, ChinaUlcerative colitis (UC) is a refractory chronic inflammatory disease involving the colon and rectum, falling under the category of inflammatory bowel disease (IBD). The accumulation of reactive oxygen species (ROS) in local tissues has been identified as a crucial contributor to the escalation of inflammatory responses. Therefore, eliminating ROS in the inflamed colon is a promising approach to treating UC. Nanomaterials with intrinsic enzyme-like activities (nanozymes) have shown significant therapeutic potential in UC. In this study, we found that platinum nanoparticles (Pt NPs) exhibited remarkable superoxide dismutase (SOD) and catalase (CAT) cascade catalytic activities, as well as effective hydroxyl radical (•OH) scavenging ability. The in vitro experiments showed that Pt NPs could eliminate excessive ROS to protect cells against oxidative stress. In the colitis model, oral administration of Pt NPs (loaded in chitosan/alginate hydrogel) could significantly alleviate UC, including reducing the colon length, the damaged epithelium, and the infiltration of inflammatory cells. Without appreciable systemic toxicity, Pt NPs represent a novel therapeutic approach to UC and are expected to achieve long-term inflammatory remission.https://www.mdpi.com/2079-4983/14/11/548ulcerative colitisplatinum (Pt NPs)nanozymeshydrogelsROS scavenging |
| spellingShingle | Hao Liu Yujie Zhang Mingzhen Zhang Zhaoxiang Yu Mingxin Zhang Oral Administration of Platinum Nanoparticles with SOD/CAT Cascade Catalytic Activity to Alleviate Ulcerative Colitis Journal of Functional Biomaterials ulcerative colitis platinum (Pt NPs) nanozymes hydrogels ROS scavenging |
| title | Oral Administration of Platinum Nanoparticles with SOD/CAT Cascade Catalytic Activity to Alleviate Ulcerative Colitis |
| title_full | Oral Administration of Platinum Nanoparticles with SOD/CAT Cascade Catalytic Activity to Alleviate Ulcerative Colitis |
| title_fullStr | Oral Administration of Platinum Nanoparticles with SOD/CAT Cascade Catalytic Activity to Alleviate Ulcerative Colitis |
| title_full_unstemmed | Oral Administration of Platinum Nanoparticles with SOD/CAT Cascade Catalytic Activity to Alleviate Ulcerative Colitis |
| title_short | Oral Administration of Platinum Nanoparticles with SOD/CAT Cascade Catalytic Activity to Alleviate Ulcerative Colitis |
| title_sort | oral administration of platinum nanoparticles with sod cat cascade catalytic activity to alleviate ulcerative colitis |
| topic | ulcerative colitis platinum (Pt NPs) nanozymes hydrogels ROS scavenging |
| url | https://www.mdpi.com/2079-4983/14/11/548 |
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