Preliminary Studies on the Synthesis of Redox-Labelled Molecularly Imprinted Nanoparticles in Sensor Development for the Quantification of Perfluoroalkyls in Water
Polyfluoroalkyl compounds (PFASs) are synthetic compounds recently classified as permanent and emerging chemicals ever since their bioaccumulation in humans and the environment, due to the presence of carbon–fluorine functional groups. The design of novel screening tools with addressed high response...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Engineering Proceedings |
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| Online Access: | https://www.mdpi.com/2673-4591/35/1/22 |
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| author | Marco Costa Sabrina Di Masi Christopher Zaleski Sergey A. Piletsky Cosimino Malitesta |
| author_facet | Marco Costa Sabrina Di Masi Christopher Zaleski Sergey A. Piletsky Cosimino Malitesta |
| author_sort | Marco Costa |
| collection | DOAJ |
| description | Polyfluoroalkyl compounds (PFASs) are synthetic compounds recently classified as permanent and emerging chemicals ever since their bioaccumulation in humans and the environment, due to the presence of carbon–fluorine functional groups. The design of novel screening tools with addressed high response time for the routine quantification of PFASs in water is highly desirable. In this work, we propose the preparation of a new voltammetric sensor based on molecularly imprinted polymer nanoparticle (nanoMIP) receptors for the highly sensitive and selective quantification of PFASs in water. The nanoMIPs were synthesized by the solid phase approach and immobilized onto functionalized screen-printed platinum electrode (SPPtE), chosen as the transduction element for sensor development. Dimensional characterization of nanoMIPs by Dynamic light scattering (DLS) shows small nanosized imprinted particles (<200 nm) with a polydispersity index (PDI) below 0.3. Electrochemical techniques were used for sensor preparation, characterization, and to assess the analytical performance, respectively. Preliminary calibration curves of nanoMIP-based sensors in a wide range of PFAS concentrations (1.5–100 ng/mL) exhibited high sensitivity toward its target. |
| first_indexed | 2024-03-10T22:48:22Z |
| format | Article |
| id | doaj.art-7e47392339894b74a3829902fa0c0f05 |
| institution | Directory Open Access Journal |
| issn | 2673-4591 |
| language | English |
| last_indexed | 2024-03-10T22:48:22Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Engineering Proceedings |
| spelling | doaj.art-7e47392339894b74a3829902fa0c0f052023-11-19T10:32:11ZengMDPI AGEngineering Proceedings2673-45912023-05-013512210.3390/IECB2023-14589Preliminary Studies on the Synthesis of Redox-Labelled Molecularly Imprinted Nanoparticles in Sensor Development for the Quantification of Perfluoroalkyls in WaterMarco Costa0Sabrina Di Masi1Christopher Zaleski2Sergey A. Piletsky3Cosimino Malitesta4Laboratorio di Chimica Analitica, Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali (DiSTeBA), Università del Salento, Via Per Monteroni, 73100 Lecce, ItalyLaboratorio di Chimica Analitica, Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali (DiSTeBA), Università del Salento, Via Per Monteroni, 73100 Lecce, ItalyDepartment of Chemistry, University of Leicester, University Rd, Leicester LE1 7RH, UKDepartment of Chemistry, University of Leicester, University Rd, Leicester LE1 7RH, UKLaboratorio di Chimica Analitica, Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali (DiSTeBA), Università del Salento, Via Per Monteroni, 73100 Lecce, ItalyPolyfluoroalkyl compounds (PFASs) are synthetic compounds recently classified as permanent and emerging chemicals ever since their bioaccumulation in humans and the environment, due to the presence of carbon–fluorine functional groups. The design of novel screening tools with addressed high response time for the routine quantification of PFASs in water is highly desirable. In this work, we propose the preparation of a new voltammetric sensor based on molecularly imprinted polymer nanoparticle (nanoMIP) receptors for the highly sensitive and selective quantification of PFASs in water. The nanoMIPs were synthesized by the solid phase approach and immobilized onto functionalized screen-printed platinum electrode (SPPtE), chosen as the transduction element for sensor development. Dimensional characterization of nanoMIPs by Dynamic light scattering (DLS) shows small nanosized imprinted particles (<200 nm) with a polydispersity index (PDI) below 0.3. Electrochemical techniques were used for sensor preparation, characterization, and to assess the analytical performance, respectively. Preliminary calibration curves of nanoMIP-based sensors in a wide range of PFAS concentrations (1.5–100 ng/mL) exhibited high sensitivity toward its target.https://www.mdpi.com/2673-4591/35/1/22molecularly imprinted polymernanoparticlessolid phase synthesisperfluorooctanoic acidscreen-printed electrodevoltammetric sensor |
| spellingShingle | Marco Costa Sabrina Di Masi Christopher Zaleski Sergey A. Piletsky Cosimino Malitesta Preliminary Studies on the Synthesis of Redox-Labelled Molecularly Imprinted Nanoparticles in Sensor Development for the Quantification of Perfluoroalkyls in Water Engineering Proceedings molecularly imprinted polymer nanoparticles solid phase synthesis perfluorooctanoic acid screen-printed electrode voltammetric sensor |
| title | Preliminary Studies on the Synthesis of Redox-Labelled Molecularly Imprinted Nanoparticles in Sensor Development for the Quantification of Perfluoroalkyls in Water |
| title_full | Preliminary Studies on the Synthesis of Redox-Labelled Molecularly Imprinted Nanoparticles in Sensor Development for the Quantification of Perfluoroalkyls in Water |
| title_fullStr | Preliminary Studies on the Synthesis of Redox-Labelled Molecularly Imprinted Nanoparticles in Sensor Development for the Quantification of Perfluoroalkyls in Water |
| title_full_unstemmed | Preliminary Studies on the Synthesis of Redox-Labelled Molecularly Imprinted Nanoparticles in Sensor Development for the Quantification of Perfluoroalkyls in Water |
| title_short | Preliminary Studies on the Synthesis of Redox-Labelled Molecularly Imprinted Nanoparticles in Sensor Development for the Quantification of Perfluoroalkyls in Water |
| title_sort | preliminary studies on the synthesis of redox labelled molecularly imprinted nanoparticles in sensor development for the quantification of perfluoroalkyls in water |
| topic | molecularly imprinted polymer nanoparticles solid phase synthesis perfluorooctanoic acid screen-printed electrode voltammetric sensor |
| url | https://www.mdpi.com/2673-4591/35/1/22 |
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