Cardiovascular Pulsatility Increases in Visual Cortex Before Blood Oxygen Level Dependent Response During Stimulus

Cardiovascular Pulsatility Increases in Visual Cortex Before Blood Oxygen Level Dependent Response During Stimulus

The physiological pulsations that drive tissue fluid homeostasis are not well characterized during brain activation. Therefore, we used fast magnetic resonance encephalography (MREG) fMRI to measure full band (0–5 Hz) blood oxygen level-dependent (BOLDFB) signals during a dynamic visual task in 23 s...

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Bibliographic Details
Main Authors: Niko Huotari, Johanna Tuunanen, Lauri Raitamaa, Ville Raatikainen, Janne Kananen, Heta Helakari, Timo Tuovinen, Matti Järvelä, Vesa Kiviniemi, Vesa Korhonen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Neuroscience
Subjects:
cardiovascular pulsations
magnetic resonance encephalography
fast fMRI
visual stimulation
task activation
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.836378/full
Description
Summary:The physiological pulsations that drive tissue fluid homeostasis are not well characterized during brain activation. Therefore, we used fast magnetic resonance encephalography (MREG) fMRI to measure full band (0–5 Hz) blood oxygen level-dependent (BOLDFB) signals during a dynamic visual task in 23 subjects. This revealed brain activity in the very low frequency (BOLDVLF) as well as in cardiac and respiratory bands. The cardiovascular hemodynamic envelope (CHe) signal correlated significantly with the visual BOLDVLF response, considered as an independent signal source in the V1-V2 visual cortices. The CHe preceded the canonical BOLDVLF response by an average of 1.3 (± 2.2) s. Physiologically, the observed CHe signal could mark increased regional cardiovascular pulsatility following vasodilation.
ISSN:1662-453X

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