Does the introduction of pre‐operative cardiopulmonary exercise testing in radical cystectomy delay or alter surgical care?
Abstract Objectives To assess if the introduction of routine pre‐operative cardiopulmonary exercise testing (CPET) in radical cystectomy has delayed surgical intervention. Materials and Methods A prospective database of patients undergoing radical cystectomy in our local health network was maintaine...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-05-01
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| Series: | BJUI Compass |
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| Online Access: | https://doi.org/10.1002/bco2.133 |
| _version_ | 1828381521244848128 |
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| author | Kathleen R. Lockhart Rosemary Carroll Albert Tiu Alison Blatt |
| author_facet | Kathleen R. Lockhart Rosemary Carroll Albert Tiu Alison Blatt |
| author_sort | Kathleen R. Lockhart |
| collection | DOAJ |
| description | Abstract Objectives To assess if the introduction of routine pre‐operative cardiopulmonary exercise testing (CPET) in radical cystectomy has delayed surgical intervention. Materials and Methods A prospective database of patients undergoing radical cystectomy in our local health network was maintained. A retrospective analysis of two years (2018–2020) included 38 patients. Of these, 15 patients had CPET pre‐operatively, and a direct comparison was performed. Results The mean time from diagnosis to cystectomy was 95 days in patients who did not have CPET compared to 110 days for those who did (p = 0.32), with comparable rates of neoadjuvant chemotherapy (NAC) (62.5% and 64.29%). Average length of stay was 18.6 days compared with 13.87 (p = 0.16), favouring the CPET group. The CPET group also had a lower readmission rate within 30 days (13.33% compared with 21.05%, p = 0.35). Cause‐specific mortality within 90 days was 10.2% and within the study timeframe was 36.84% (estimated 5‐year mortality rate 43–65%). Within the CPET group, eight had an anaerobic threshold (AT) of <11 ml/kg/min (range 6.3–10.5): Of these, 50% had Clavien‐Dindo complications of grade 2 or higher and the 90‐day mortality rate was 37.5% (cf. 0% in those with AT > 11 ml/kg/min in this series). Conclusion CPET is a valuable risk evaluation tool. This study suggested that CPET contributed to a minor non‐significant delay to surgery, however was associated with reduced length of stay and readmission rates, and was a valuable risk evaluation tool. We found that CPET AT <11 ml/kg/min is associated with higher rates of patient morbidity and perioperative mortality. |
| first_indexed | 2024-12-10T04:15:20Z |
| format | Article |
| id | doaj.art-7e48871f85fe404d997fffbf12fb71f1 |
| institution | Directory Open Access Journal |
| issn | 2688-4526 |
| language | English |
| last_indexed | 2024-12-10T04:15:20Z |
| publishDate | 2022-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | BJUI Compass |
| spelling | doaj.art-7e48871f85fe404d997fffbf12fb71f12022-12-22T02:02:36ZengWileyBJUI Compass2688-45262022-05-013323824210.1002/bco2.133Does the introduction of pre‐operative cardiopulmonary exercise testing in radical cystectomy delay or alter surgical care?Kathleen R. Lockhart0Rosemary Carroll1Albert Tiu2Alison Blatt3John Hunter Hospital Newcastle New South Wales AustraliaJohn Hunter Hospital Newcastle New South Wales AustraliaJohn Hunter Hospital Newcastle New South Wales AustraliaJohn Hunter Hospital Newcastle New South Wales AustraliaAbstract Objectives To assess if the introduction of routine pre‐operative cardiopulmonary exercise testing (CPET) in radical cystectomy has delayed surgical intervention. Materials and Methods A prospective database of patients undergoing radical cystectomy in our local health network was maintained. A retrospective analysis of two years (2018–2020) included 38 patients. Of these, 15 patients had CPET pre‐operatively, and a direct comparison was performed. Results The mean time from diagnosis to cystectomy was 95 days in patients who did not have CPET compared to 110 days for those who did (p = 0.32), with comparable rates of neoadjuvant chemotherapy (NAC) (62.5% and 64.29%). Average length of stay was 18.6 days compared with 13.87 (p = 0.16), favouring the CPET group. The CPET group also had a lower readmission rate within 30 days (13.33% compared with 21.05%, p = 0.35). Cause‐specific mortality within 90 days was 10.2% and within the study timeframe was 36.84% (estimated 5‐year mortality rate 43–65%). Within the CPET group, eight had an anaerobic threshold (AT) of <11 ml/kg/min (range 6.3–10.5): Of these, 50% had Clavien‐Dindo complications of grade 2 or higher and the 90‐day mortality rate was 37.5% (cf. 0% in those with AT > 11 ml/kg/min in this series). Conclusion CPET is a valuable risk evaluation tool. This study suggested that CPET contributed to a minor non‐significant delay to surgery, however was associated with reduced length of stay and readmission rates, and was a valuable risk evaluation tool. We found that CPET AT <11 ml/kg/min is associated with higher rates of patient morbidity and perioperative mortality.https://doi.org/10.1002/bco2.133anaerobic thresholdbladder cancercardiopulmonary exercise testperioperative careradical cystectomy |
| spellingShingle | Kathleen R. Lockhart Rosemary Carroll Albert Tiu Alison Blatt Does the introduction of pre‐operative cardiopulmonary exercise testing in radical cystectomy delay or alter surgical care? BJUI Compass anaerobic threshold bladder cancer cardiopulmonary exercise test perioperative care radical cystectomy |
| title | Does the introduction of pre‐operative cardiopulmonary exercise testing in radical cystectomy delay or alter surgical care? |
| title_full | Does the introduction of pre‐operative cardiopulmonary exercise testing in radical cystectomy delay or alter surgical care? |
| title_fullStr | Does the introduction of pre‐operative cardiopulmonary exercise testing in radical cystectomy delay or alter surgical care? |
| title_full_unstemmed | Does the introduction of pre‐operative cardiopulmonary exercise testing in radical cystectomy delay or alter surgical care? |
| title_short | Does the introduction of pre‐operative cardiopulmonary exercise testing in radical cystectomy delay or alter surgical care? |
| title_sort | does the introduction of pre operative cardiopulmonary exercise testing in radical cystectomy delay or alter surgical care |
| topic | anaerobic threshold bladder cancer cardiopulmonary exercise test perioperative care radical cystectomy |
| url | https://doi.org/10.1002/bco2.133 |
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