The SocioBox: A novel paradigm to assess complex social recognition in male mice
Impairments in social skills are central to mental disease, and developing tools for their assessment in mouse models is essential. Here we present the SocioBox, a new behavioral paradigm to measure social recognition memory. Using this paradigm, we show that male wildtype mice of different strains...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-08-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2016.00151/full |
| _version_ | 1828417656856772608 |
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| author | Dilja Krueger-Burg Daniela Winkler Mišo Mitkovski Fernanda Daher Anja Ronnenberg Oliver Marcus Schlüter Ekrem Dere Hannelore Ehrenreich |
| author_facet | Dilja Krueger-Burg Daniela Winkler Mišo Mitkovski Fernanda Daher Anja Ronnenberg Oliver Marcus Schlüter Ekrem Dere Hannelore Ehrenreich |
| author_sort | Dilja Krueger-Burg |
| collection | DOAJ |
| description | Impairments in social skills are central to mental disease, and developing tools for their assessment in mouse models is essential. Here we present the SocioBox, a new behavioral paradigm to measure social recognition memory. Using this paradigm, we show that male wildtype mice of different strains can readily identify an unfamiliar mouse among 5 newly acquainted animals. In contrast, female mice exhibit lower locomotor activity during social exploration in the SocioBox compared to males and do not seem to discriminate between acquainted and unfamiliar mice, likely reflecting inherent differences in gender-specific territorial tasks. In addition to a simple quantification of social interaction time of mice grounded on predefined spatial zones (zone-based method), we developed a set of unbiased, data-driven analysis tools based on heat map representations and characterized by greater sensitivity. First proof-of-principle that the SocioBox allows diagnosis of social recognition memory deficits is provided using male PSD-95 heterozygous knockout mice, a mouse model related to psychiatric pathophysiology. |
| first_indexed | 2024-12-10T14:24:47Z |
| format | Article |
| id | doaj.art-7e4a82030f5a47cab2f4774439714802 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-10T14:24:47Z |
| publishDate | 2016-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-7e4a82030f5a47cab2f47744397148022022-12-22T01:45:07ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532016-08-011010.3389/fnbeh.2016.00151210514The SocioBox: A novel paradigm to assess complex social recognition in male miceDilja Krueger-Burg0Daniela Winkler1Mišo Mitkovski2Fernanda Daher3Anja Ronnenberg4Oliver Marcus Schlüter5Ekrem Dere6Hannelore Ehrenreich7Max Planck Institute of Experimental MedicineMax Planck Institute of Experimental MedicineMax Planck Institute of Experimental MedicineMax Planck Institute of Experimental MedicineMax Planck Institute of Experimental MedicineEuropean Neuroscience InstituteUniversity Pierre and Marie Curie Paris 6Max Planck Institute of Experimental MedicineImpairments in social skills are central to mental disease, and developing tools for their assessment in mouse models is essential. Here we present the SocioBox, a new behavioral paradigm to measure social recognition memory. Using this paradigm, we show that male wildtype mice of different strains can readily identify an unfamiliar mouse among 5 newly acquainted animals. In contrast, female mice exhibit lower locomotor activity during social exploration in the SocioBox compared to males and do not seem to discriminate between acquainted and unfamiliar mice, likely reflecting inherent differences in gender-specific territorial tasks. In addition to a simple quantification of social interaction time of mice grounded on predefined spatial zones (zone-based method), we developed a set of unbiased, data-driven analysis tools based on heat map representations and characterized by greater sensitivity. First proof-of-principle that the SocioBox allows diagnosis of social recognition memory deficits is provided using male PSD-95 heterozygous knockout mice, a mouse model related to psychiatric pathophysiology.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2016.00151/fullBehaviorSchizophreniaautismgender differencesmouse modelPSD-95 |
| spellingShingle | Dilja Krueger-Burg Daniela Winkler Mišo Mitkovski Fernanda Daher Anja Ronnenberg Oliver Marcus Schlüter Ekrem Dere Hannelore Ehrenreich The SocioBox: A novel paradigm to assess complex social recognition in male mice Frontiers in Behavioral Neuroscience Behavior Schizophrenia autism gender differences mouse model PSD-95 |
| title | The SocioBox: A novel paradigm to assess complex social recognition in male mice |
| title_full | The SocioBox: A novel paradigm to assess complex social recognition in male mice |
| title_fullStr | The SocioBox: A novel paradigm to assess complex social recognition in male mice |
| title_full_unstemmed | The SocioBox: A novel paradigm to assess complex social recognition in male mice |
| title_short | The SocioBox: A novel paradigm to assess complex social recognition in male mice |
| title_sort | sociobox a novel paradigm to assess complex social recognition in male mice |
| topic | Behavior Schizophrenia autism gender differences mouse model PSD-95 |
| url | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2016.00151/full |
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