Is There a Link between COVID-19 Infection, Periodontal Disease and Acute Myocardial Infarction?
Both periodontal disease and atherosclerosis are chronic disorders with an inflammatory substrate that leads to alteration of the host’s immune response. In PD, inflammation is responsible for bone tissue destruction, while in atherosclerosis, it leads to atheromatous plaque formation. These modific...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-10-01
|
| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/11/10/1050 |
| _version_ | 1797514109160259584 |
|---|---|
| author | Ioana-Patricia Rodean Carmen-Ioana Biriș Vasile-Bogdan Halațiu Andrei Modiga Luminița Lazăr Imre Benedek Theodora Benedek |
| author_facet | Ioana-Patricia Rodean Carmen-Ioana Biriș Vasile-Bogdan Halațiu Andrei Modiga Luminița Lazăr Imre Benedek Theodora Benedek |
| author_sort | Ioana-Patricia Rodean |
| collection | DOAJ |
| description | Both periodontal disease and atherosclerosis are chronic disorders with an inflammatory substrate that leads to alteration of the host’s immune response. In PD, inflammation is responsible for bone tissue destruction, while in atherosclerosis, it leads to atheromatous plaque formation. These modifications result from the action of pro-inflammatory cytokines that are secreted both locally at gingival or coronary sites, and systemically. Recently, it was observed that in patients with PD or with cardiovascular disease, COVID-19 infection is prone to be more severe. While the association between PD, inflammation and cardiovascular disease is well-known, the impact of COVID-19-related inflammation on the systemic complications of these conditions has not been established yet. The purpose of this review is to bring light upon the latest advances in understanding the link between periodontal–cardiovascular diseases and COVID-19 infection. |
| first_indexed | 2024-03-10T06:26:58Z |
| format | Article |
| id | doaj.art-7e4c17050fe5429bbe8dff9910b6d210 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T06:26:58Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-7e4c17050fe5429bbe8dff9910b6d2102023-11-22T18:52:45ZengMDPI AGLife2075-17292021-10-011110105010.3390/life11101050Is There a Link between COVID-19 Infection, Periodontal Disease and Acute Myocardial Infarction?Ioana-Patricia Rodean0Carmen-Ioana Biriș1Vasile-Bogdan Halațiu2Andrei Modiga3Luminița Lazăr4Imre Benedek5Theodora Benedek6Clinic of Cardiology, Emergency Clinical County Hospital, 540136 Târgu Mureș, Romania“George Emil Palade” University of Medicine, Pharmacy, Science and Technology, 540139 Târgu Mureș, RomaniaClinic of Cardiology, Emergency Clinical County Hospital, 540136 Târgu Mureș, Romania“George Emil Palade” University of Medicine, Pharmacy, Science and Technology, 540139 Târgu Mureș, Romania“George Emil Palade” University of Medicine, Pharmacy, Science and Technology, 540139 Târgu Mureș, RomaniaClinic of Cardiology, Emergency Clinical County Hospital, 540136 Târgu Mureș, RomaniaClinic of Cardiology, Emergency Clinical County Hospital, 540136 Târgu Mureș, RomaniaBoth periodontal disease and atherosclerosis are chronic disorders with an inflammatory substrate that leads to alteration of the host’s immune response. In PD, inflammation is responsible for bone tissue destruction, while in atherosclerosis, it leads to atheromatous plaque formation. These modifications result from the action of pro-inflammatory cytokines that are secreted both locally at gingival or coronary sites, and systemically. Recently, it was observed that in patients with PD or with cardiovascular disease, COVID-19 infection is prone to be more severe. While the association between PD, inflammation and cardiovascular disease is well-known, the impact of COVID-19-related inflammation on the systemic complications of these conditions has not been established yet. The purpose of this review is to bring light upon the latest advances in understanding the link between periodontal–cardiovascular diseases and COVID-19 infection.https://www.mdpi.com/2075-1729/11/10/1050acute coronary syndromeCOVID-19 infectioncytokine storminflammationmiRNAperiodontal disease |
| spellingShingle | Ioana-Patricia Rodean Carmen-Ioana Biriș Vasile-Bogdan Halațiu Andrei Modiga Luminița Lazăr Imre Benedek Theodora Benedek Is There a Link between COVID-19 Infection, Periodontal Disease and Acute Myocardial Infarction? Life acute coronary syndrome COVID-19 infection cytokine storm inflammation miRNA periodontal disease |
| title | Is There a Link between COVID-19 Infection, Periodontal Disease and Acute Myocardial Infarction? |
| title_full | Is There a Link between COVID-19 Infection, Periodontal Disease and Acute Myocardial Infarction? |
| title_fullStr | Is There a Link between COVID-19 Infection, Periodontal Disease and Acute Myocardial Infarction? |
| title_full_unstemmed | Is There a Link between COVID-19 Infection, Periodontal Disease and Acute Myocardial Infarction? |
| title_short | Is There a Link between COVID-19 Infection, Periodontal Disease and Acute Myocardial Infarction? |
| title_sort | is there a link between covid 19 infection periodontal disease and acute myocardial infarction |
| topic | acute coronary syndrome COVID-19 infection cytokine storm inflammation miRNA periodontal disease |
| url | https://www.mdpi.com/2075-1729/11/10/1050 |
| work_keys_str_mv | AT ioanapatriciarodean istherealinkbetweencovid19infectionperiodontaldiseaseandacutemyocardialinfarction AT carmenioanabiris istherealinkbetweencovid19infectionperiodontaldiseaseandacutemyocardialinfarction AT vasilebogdanhalatiu istherealinkbetweencovid19infectionperiodontaldiseaseandacutemyocardialinfarction AT andreimodiga istherealinkbetweencovid19infectionperiodontaldiseaseandacutemyocardialinfarction AT luminitalazar istherealinkbetweencovid19infectionperiodontaldiseaseandacutemyocardialinfarction AT imrebenedek istherealinkbetweencovid19infectionperiodontaldiseaseandacutemyocardialinfarction AT theodorabenedek istherealinkbetweencovid19infectionperiodontaldiseaseandacutemyocardialinfarction |