Mycobacteriophages in diagnosis and alternative treatment of mycobacterial infections
Antimicrobial resistance is an increasing threat to human populations. The emergence of multidrug-resistant “superbugs” in mycobacterial infections has further complicated the processes of curing patients, thereby resulting in high morbidity and mortality. Early diagnosis and alternative treatment a...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1277178/full |
| _version_ | 1797262519373398016 |
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| author | Xudong Ouyang Xudong Ouyang Xiaotian Li Xiaotian Li Jinmiao Song Jinmiao Song Hui Wang Hui Wang Shuxian Wang Shuxian Wang Ren Fang Ren Fang Zhaoli Li Ningning Song Ningning Song |
| author_facet | Xudong Ouyang Xudong Ouyang Xiaotian Li Xiaotian Li Jinmiao Song Jinmiao Song Hui Wang Hui Wang Shuxian Wang Shuxian Wang Ren Fang Ren Fang Zhaoli Li Ningning Song Ningning Song |
| author_sort | Xudong Ouyang |
| collection | DOAJ |
| description | Antimicrobial resistance is an increasing threat to human populations. The emergence of multidrug-resistant “superbugs” in mycobacterial infections has further complicated the processes of curing patients, thereby resulting in high morbidity and mortality. Early diagnosis and alternative treatment are important for improving the success and cure rates associated with mycobacterial infections and the use of mycobacteriophages is a potentially good option. Since each bacteriophage has its own host range, mycobacteriophages have the capacity to detect specific mycobacterial isolates. The bacteriolysis properties of mycobacteriophages make them more attractive when it comes to treating infectious diseases. In fact, they have been clinically applied in Eastern Europe for several decades. Therefore, mycobacteriophages can also treat mycobacteria infections. This review explores the potential clinical applications of mycobacteriophages, including phage-based diagnosis and phage therapy in mycobacterial infections. Furthermore, this review summarizes the current difficulties in phage therapy, providing insights into new treatment strategies against drug-resistant mycobacteria. |
| first_indexed | 2024-04-24T23:58:24Z |
| format | Article |
| id | doaj.art-7e4d88882c5d402084fe74e52d16d933 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-24T23:58:24Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-7e4d88882c5d402084fe74e52d16d9332024-03-14T10:51:15ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-09-011410.3389/fmicb.2023.12771781277178Mycobacteriophages in diagnosis and alternative treatment of mycobacterial infectionsXudong Ouyang0Xudong Ouyang1Xiaotian Li2Xiaotian Li3Jinmiao Song4Jinmiao Song5Hui Wang6Hui Wang7Shuxian Wang8Shuxian Wang9Ren Fang10Ren Fang11Zhaoli Li12Ningning Song13Ningning Song14School of Life Science and Technology, Weifang Medical University, Weifang, ChinaWeifang Key Laboratory of Respiratory Tract Pathogens and Drug Therapy, Weifang, ChinaSchool of Life Science and Technology, Weifang Medical University, Weifang, ChinaWeifang Key Laboratory of Respiratory Tract Pathogens and Drug Therapy, Weifang, ChinaSchool of Life Science and Technology, Weifang Medical University, Weifang, ChinaWeifang Key Laboratory of Respiratory Tract Pathogens and Drug Therapy, Weifang, ChinaSchool of Life Science and Technology, Weifang Medical University, Weifang, ChinaWeifang Key Laboratory of Respiratory Tract Pathogens and Drug Therapy, Weifang, ChinaSchool of Life Science and Technology, Weifang Medical University, Weifang, ChinaWeifang Key Laboratory of Respiratory Tract Pathogens and Drug Therapy, Weifang, ChinaSchool of Life Science and Technology, Weifang Medical University, Weifang, ChinaWeifang Key Laboratory of Respiratory Tract Pathogens and Drug Therapy, Weifang, ChinaSAFE Pharmaceutical Technology Co. Ltd., Beijing, ChinaSchool of Life Science and Technology, Weifang Medical University, Weifang, ChinaWeifang Key Laboratory of Respiratory Tract Pathogens and Drug Therapy, Weifang, ChinaAntimicrobial resistance is an increasing threat to human populations. The emergence of multidrug-resistant “superbugs” in mycobacterial infections has further complicated the processes of curing patients, thereby resulting in high morbidity and mortality. Early diagnosis and alternative treatment are important for improving the success and cure rates associated with mycobacterial infections and the use of mycobacteriophages is a potentially good option. Since each bacteriophage has its own host range, mycobacteriophages have the capacity to detect specific mycobacterial isolates. The bacteriolysis properties of mycobacteriophages make them more attractive when it comes to treating infectious diseases. In fact, they have been clinically applied in Eastern Europe for several decades. Therefore, mycobacteriophages can also treat mycobacteria infections. This review explores the potential clinical applications of mycobacteriophages, including phage-based diagnosis and phage therapy in mycobacterial infections. Furthermore, this review summarizes the current difficulties in phage therapy, providing insights into new treatment strategies against drug-resistant mycobacteria.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1277178/fullmycobacteriophagemycobacterial infectionnon-tuberculous mycobacteriaphage therapyMycobacterium tuberculosis |
| spellingShingle | Xudong Ouyang Xudong Ouyang Xiaotian Li Xiaotian Li Jinmiao Song Jinmiao Song Hui Wang Hui Wang Shuxian Wang Shuxian Wang Ren Fang Ren Fang Zhaoli Li Ningning Song Ningning Song Mycobacteriophages in diagnosis and alternative treatment of mycobacterial infections Frontiers in Microbiology mycobacteriophage mycobacterial infection non-tuberculous mycobacteria phage therapy Mycobacterium tuberculosis |
| title | Mycobacteriophages in diagnosis and alternative treatment of mycobacterial infections |
| title_full | Mycobacteriophages in diagnosis and alternative treatment of mycobacterial infections |
| title_fullStr | Mycobacteriophages in diagnosis and alternative treatment of mycobacterial infections |
| title_full_unstemmed | Mycobacteriophages in diagnosis and alternative treatment of mycobacterial infections |
| title_short | Mycobacteriophages in diagnosis and alternative treatment of mycobacterial infections |
| title_sort | mycobacteriophages in diagnosis and alternative treatment of mycobacterial infections |
| topic | mycobacteriophage mycobacterial infection non-tuberculous mycobacteria phage therapy Mycobacterium tuberculosis |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1277178/full |
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