Progress in CRISPR/Cas9 for CAR-T cell therapy of tumors
CRISPR/Cas9 gene editing technology can effectively solve the problem of insufficient source of T cells in chimerical antigen receptor-T (CAR-T) therapy and enhance their anti-tumor abilities by knocking out the genes related to the suppression of T cells activity. The technology can also be used to...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2023-08-01
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| Series: | Jichu yixue yu linchuang |
| Subjects: | |
| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2023-43-8-1313.pdf |
| _version_ | 1797366356139573248 |
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| author | WU Qi, WANG Shaobo |
| author_facet | WU Qi, WANG Shaobo |
| author_sort | WU Qi, WANG Shaobo |
| collection | DOAJ |
| description | CRISPR/Cas9 gene editing technology can effectively solve the problem of insufficient source of T cells in chimerical antigen receptor-T (CAR-T) therapy and enhance their anti-tumor abilities by knocking out the genes related to the suppression of T cells activity. The technology can also be used to construct T cells with dual-targeting effect to stop tumor immune escape and inhibit recurrence and drug resistance development during chemotherapy. Compared with the other genetic engineering technologies that have complex processes, multiple genome editing by CRISPR/Cas9 is a technology of efficient and convenient to operate.So it is believed to be valuable and potential target molecules for CAR-T therapy. |
| first_indexed | 2024-03-08T17:03:04Z |
| format | Article |
| id | doaj.art-7e4dfbf6903648a385ac6ee128934cb3 |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T17:03:04Z |
| publishDate | 2023-08-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-7e4dfbf6903648a385ac6ee128934cb32024-01-04T07:33:24ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252023-08-014381313131610.16352/j.issn.1001-6325.2023.08.1313Progress in CRISPR/Cas9 for CAR-T cell therapy of tumorsWU Qi, WANG Shaobo0PET/CT Center, the Affiliated Hospital of Kunming University of Science and Technology, the First People's Hospital of Yunnan Province, Kunming 650032, ChinaCRISPR/Cas9 gene editing technology can effectively solve the problem of insufficient source of T cells in chimerical antigen receptor-T (CAR-T) therapy and enhance their anti-tumor abilities by knocking out the genes related to the suppression of T cells activity. The technology can also be used to construct T cells with dual-targeting effect to stop tumor immune escape and inhibit recurrence and drug resistance development during chemotherapy. Compared with the other genetic engineering technologies that have complex processes, multiple genome editing by CRISPR/Cas9 is a technology of efficient and convenient to operate.So it is believed to be valuable and potential target molecules for CAR-T therapy.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2023-43-8-1313.pdfcar-t cells|crispr/cas9|immunotherapy |
| spellingShingle | WU Qi, WANG Shaobo Progress in CRISPR/Cas9 for CAR-T cell therapy of tumors Jichu yixue yu linchuang car-t cells|crispr/cas9|immunotherapy |
| title | Progress in CRISPR/Cas9 for CAR-T cell therapy of tumors |
| title_full | Progress in CRISPR/Cas9 for CAR-T cell therapy of tumors |
| title_fullStr | Progress in CRISPR/Cas9 for CAR-T cell therapy of tumors |
| title_full_unstemmed | Progress in CRISPR/Cas9 for CAR-T cell therapy of tumors |
| title_short | Progress in CRISPR/Cas9 for CAR-T cell therapy of tumors |
| title_sort | progress in crispr cas9 for car t cell therapy of tumors |
| topic | car-t cells|crispr/cas9|immunotherapy |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2023-43-8-1313.pdf |
| work_keys_str_mv | AT wuqiwangshaobo progressincrisprcas9forcartcelltherapyoftumors |