A case of repeated in-stent restenosis of coronary artery as a primary manifestation of seronegative antiphospholipid antibody syndrome
Abstract Background Antiphospholipid antibody syndrome (APS) is a multisystemic autoimmune disorder which affects many organs or systems; however, coronary artery is relatively less frequently involved. Case presentation A 65-year-old female with effort chest pain was hospitalized for unstable angin...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-023-03568-2 |
| _version_ | 1797363673759481856 |
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| author | Mingqiang Fu Shufu Chang Jianying Ma Junbo Ge |
| author_facet | Mingqiang Fu Shufu Chang Jianying Ma Junbo Ge |
| author_sort | Mingqiang Fu |
| collection | DOAJ |
| description | Abstract Background Antiphospholipid antibody syndrome (APS) is a multisystemic autoimmune disorder which affects many organs or systems; however, coronary artery is relatively less frequently involved. Case presentation A 65-year-old female with effort chest pain was hospitalized for unstable angina in Janurary, 2015. Coronary angiography revealed sub-total occlusion of proximal left anterior descending (LAD) coronary artery, where a drug-eluting stent was successfully deployed. The patient experienced multiple in-stent stenosis at LAD coronary artery and coronary artery bypass graft (CABG) surgery was advised. Subsequently, severe stenosis of left circumflex (LCX) coronary artery emerged, and the patient suffered persistent in-stent restenosis. Eventually, the patient was diagnosed with seronegative antiphospholipid antibody syndrome and salvaged by immunosuppressants. Conclusions Repeated in-stent restenosis could be a primary manifestation of seronegative antiphospholipid antibody syndrome, and suppression of autoimmune activity and inflammation other than purely coronary revascularization might be a better option. |
| first_indexed | 2024-03-08T16:24:22Z |
| format | Article |
| id | doaj.art-7e4e702c1e804b64a75c064a9c96ad5b |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-03-08T16:24:22Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-7e4e702c1e804b64a75c064a9c96ad5b2024-01-07T12:09:52ZengBMCBMC Cardiovascular Disorders1471-22612024-01-012411710.1186/s12872-023-03568-2A case of repeated in-stent restenosis of coronary artery as a primary manifestation of seronegative antiphospholipid antibody syndromeMingqiang Fu0Shufu Chang1Jianying Ma2Junbo Ge3Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular DiseasesDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular DiseasesDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular DiseasesDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular DiseasesAbstract Background Antiphospholipid antibody syndrome (APS) is a multisystemic autoimmune disorder which affects many organs or systems; however, coronary artery is relatively less frequently involved. Case presentation A 65-year-old female with effort chest pain was hospitalized for unstable angina in Janurary, 2015. Coronary angiography revealed sub-total occlusion of proximal left anterior descending (LAD) coronary artery, where a drug-eluting stent was successfully deployed. The patient experienced multiple in-stent stenosis at LAD coronary artery and coronary artery bypass graft (CABG) surgery was advised. Subsequently, severe stenosis of left circumflex (LCX) coronary artery emerged, and the patient suffered persistent in-stent restenosis. Eventually, the patient was diagnosed with seronegative antiphospholipid antibody syndrome and salvaged by immunosuppressants. Conclusions Repeated in-stent restenosis could be a primary manifestation of seronegative antiphospholipid antibody syndrome, and suppression of autoimmune activity and inflammation other than purely coronary revascularization might be a better option.https://doi.org/10.1186/s12872-023-03568-2Coronary artery diseasePercutaneous coronary interventionIn-stent restenosisAntiphospholipid antibody syndromeImmunotherapy |
| spellingShingle | Mingqiang Fu Shufu Chang Jianying Ma Junbo Ge A case of repeated in-stent restenosis of coronary artery as a primary manifestation of seronegative antiphospholipid antibody syndrome BMC Cardiovascular Disorders Coronary artery disease Percutaneous coronary intervention In-stent restenosis Antiphospholipid antibody syndrome Immunotherapy |
| title | A case of repeated in-stent restenosis of coronary artery as a primary manifestation of seronegative antiphospholipid antibody syndrome |
| title_full | A case of repeated in-stent restenosis of coronary artery as a primary manifestation of seronegative antiphospholipid antibody syndrome |
| title_fullStr | A case of repeated in-stent restenosis of coronary artery as a primary manifestation of seronegative antiphospholipid antibody syndrome |
| title_full_unstemmed | A case of repeated in-stent restenosis of coronary artery as a primary manifestation of seronegative antiphospholipid antibody syndrome |
| title_short | A case of repeated in-stent restenosis of coronary artery as a primary manifestation of seronegative antiphospholipid antibody syndrome |
| title_sort | case of repeated in stent restenosis of coronary artery as a primary manifestation of seronegative antiphospholipid antibody syndrome |
| topic | Coronary artery disease Percutaneous coronary intervention In-stent restenosis Antiphospholipid antibody syndrome Immunotherapy |
| url | https://doi.org/10.1186/s12872-023-03568-2 |
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