In Silico Evaluation of the Potential Association of the Pathogenic Mutations of Alpha Synuclein Protein with Induction of Synucleinopathies

In Silico Evaluation of the Potential Association of the Pathogenic Mutations of Alpha Synuclein Protein with Induction of Synucleinopathies

Alpha synuclein (α-Syn) is a neuronal protein encoded by the SNCA gene and is involved in the development of Parkinson’s disease (PD). The objective of this study was to examine in silico the functional implications of non-synonymous single nucleotide polymorphisms (nsSNPs) in the SNCA gene. We used...

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Bibliographic Details
Main Authors: Mohamed E. Elnageeb, Imadeldin Elfaki, Khalid M. Adam, Elsadig Mohamed Ahmed, Elkhalifa M. Elkhalifa, Hytham A. Abuagla, Abubakr Ali Elamin Mohamed Ahmed, Elshazali Widaa Ali, Elmoiz Idris Eltieb, Ali M. Edris
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Diseases
Subjects:
synucleinopathies
Parkinson’s disease (PD)
alpha-synuclein (α-Syn) protein
SNCA gene non-synonymous single nucleotide polymorphisms (nsSNPs)
bioinformatics
Online Access:https://www.mdpi.com/2079-9721/11/3/115

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