Investigation of Prognostic Markers of Lung Adenocarcinoma Based on Tumor Metabolism-Related Genes
Lung adenocarcinoma (LUAD) is a prevalent cancer killer. Investigation on potential prognostic markers of LUAD is crucial for a patient’s postoperative planning. LUAD-associated datasets were acquired from Gene Expression Omnibus (GEO) as well as The Cancer Genome Atlas (TCGA). LUAD metabolism-assoc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2021.760506/full |
| _version_ | 1818581692730834944 |
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| author | Chong Zhang Zhehao He Ling Cheng Jinlin Cao |
| author_facet | Chong Zhang Zhehao He Ling Cheng Jinlin Cao |
| author_sort | Chong Zhang |
| collection | DOAJ |
| description | Lung adenocarcinoma (LUAD) is a prevalent cancer killer. Investigation on potential prognostic markers of LUAD is crucial for a patient’s postoperative planning. LUAD-associated datasets were acquired from Gene Expression Omnibus (GEO) as well as The Cancer Genome Atlas (TCGA). LUAD metabolism-associated differentially expressed genes were obtained, combining tumor metabolism-associated genes. COX regression analyses were conducted to build a five-gene prognostic model. Samples were divided into high- and low-risk groups by the established model. Survival analysis displayed favorable prognosis in the low-risk group in the training set. Favorable predictive performance of the model was discovered as hinted by receiver’s operative curve (ROC). Survival analysis and ROC analysis in the validation set held an agreement. Gene Set Enrichment Analysis (GSEA), tumor mutation bearing (TMB), and immune infiltration differential analysis were performed. The two groups displayed differences in glycolysis gluconeogenesis, P53 signaling pathway, etc. The high-risk group showed higher TP53 mutation frequency as well as TMB. The low-risk group displayed higher immune activity along with immune score. Altogether, this study casts light on further development of novel prognostic markers for LUAD. |
| first_indexed | 2024-12-16T07:37:32Z |
| format | Article |
| id | doaj.art-7e4f0a2ef40f475c815a04f2ba516c29 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-16T07:37:32Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-7e4f0a2ef40f475c815a04f2ba516c292022-12-21T22:39:11ZengFrontiers Media S.A.Frontiers in Genetics1664-80212021-10-011210.3389/fgene.2021.760506760506Investigation of Prognostic Markers of Lung Adenocarcinoma Based on Tumor Metabolism-Related GenesChong Zhang0Zhehao He1Ling Cheng2Jinlin Cao3Department of Thoracic Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Thoracic Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaShanghai Engineering Research Center of Pharmaceutical Translation, Shanghai, ChinaDepartment of Thoracic Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaLung adenocarcinoma (LUAD) is a prevalent cancer killer. Investigation on potential prognostic markers of LUAD is crucial for a patient’s postoperative planning. LUAD-associated datasets were acquired from Gene Expression Omnibus (GEO) as well as The Cancer Genome Atlas (TCGA). LUAD metabolism-associated differentially expressed genes were obtained, combining tumor metabolism-associated genes. COX regression analyses were conducted to build a five-gene prognostic model. Samples were divided into high- and low-risk groups by the established model. Survival analysis displayed favorable prognosis in the low-risk group in the training set. Favorable predictive performance of the model was discovered as hinted by receiver’s operative curve (ROC). Survival analysis and ROC analysis in the validation set held an agreement. Gene Set Enrichment Analysis (GSEA), tumor mutation bearing (TMB), and immune infiltration differential analysis were performed. The two groups displayed differences in glycolysis gluconeogenesis, P53 signaling pathway, etc. The high-risk group showed higher TP53 mutation frequency as well as TMB. The low-risk group displayed higher immune activity along with immune score. Altogether, this study casts light on further development of novel prognostic markers for LUAD.https://www.frontiersin.org/articles/10.3389/fgene.2021.760506/fulllung adenocarcinomaprognosis predictionGSEA enrichment analysisTP53immune infiltration |
| spellingShingle | Chong Zhang Zhehao He Ling Cheng Jinlin Cao Investigation of Prognostic Markers of Lung Adenocarcinoma Based on Tumor Metabolism-Related Genes Frontiers in Genetics lung adenocarcinoma prognosis prediction GSEA enrichment analysis TP53 immune infiltration |
| title | Investigation of Prognostic Markers of Lung Adenocarcinoma Based on Tumor Metabolism-Related Genes |
| title_full | Investigation of Prognostic Markers of Lung Adenocarcinoma Based on Tumor Metabolism-Related Genes |
| title_fullStr | Investigation of Prognostic Markers of Lung Adenocarcinoma Based on Tumor Metabolism-Related Genes |
| title_full_unstemmed | Investigation of Prognostic Markers of Lung Adenocarcinoma Based on Tumor Metabolism-Related Genes |
| title_short | Investigation of Prognostic Markers of Lung Adenocarcinoma Based on Tumor Metabolism-Related Genes |
| title_sort | investigation of prognostic markers of lung adenocarcinoma based on tumor metabolism related genes |
| topic | lung adenocarcinoma prognosis prediction GSEA enrichment analysis TP53 immune infiltration |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2021.760506/full |
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