Isolation and characterization of cytotoxic and insulin-releasing components from the venom of the black-necked spitting cobra Naja nigricollis (Elapidae)

Isolation and characterization of cytotoxic and insulin-releasing components from the venom of the black-necked spitting cobra Naja nigricollis (Elapidae)

Four peptides with cytotoxic activity against BRIN-BD11 rat clonal β-cells were purified from the venom of the black-necked spitting cobra Naja nigricollis using reversed-phase HPLC. The peptides were identified as members of the three-finger superfamily of snake toxins by ESI-MS/MS sequencing of tr...

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Bibliographic Details
Main Authors: J.M. Conlon, Samir Attoub, Vishal Musale, Jérôme Leprince, Nicholas R. Casewell, Libia Sanz, Juan J. Calvete
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Toxicon: X
Subjects:
Naja
Cytotoxicity
Insulinotropic activity
Three-finger toxins
Phospholipase A2
Online Access:http://www.sciencedirect.com/science/article/pii/S2590171020300084

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