Granzymes in health and diseases: the good, the bad and the ugly

Granzymes in health and diseases: the good, the bad and the ugly

Granzymes are a family of serine proteases, composed of five human members: GA, B, H, M and K. They were first discovered in the 1980s within cytotoxic granules released during NK cell- and T cell-mediated killing. Through their various proteolytic activities, granzymes can trigger different pathway...

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Bibliographic Details
Main Authors:	Lavinia Cigalotto, Denis Martinvalet
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-04-01
Series:	Frontiers in Immunology
Subjects:	granzyme cytotoxic lymphocytes cancer inflammation wound healing
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1371743/full

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