The liver and the haemeostatic system
The liver plays a central role in the control of haemostasis being the site of synthesis of most of the coagulation factors and natural anticoagulants, as well as fibrinolytic factors except the main activators of the fibrinolytic system (t-PA and u-PA). The liver also clears many of the activated c...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2003-01-01
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| Series: | The Saudi Journal of Gastroenterology |
| Subjects: | |
| Online Access: | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2003;volume=9;issue=2;spage=59;epage=68;aulast=Al |
| _version_ | 1818824513552384000 |
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| author | Al Ghumlas Abeer AbdelGader Abdel |
| author_facet | Al Ghumlas Abeer AbdelGader Abdel |
| author_sort | Al Ghumlas Abeer |
| collection | DOAJ |
| description | The liver plays a central role in the control of haemostasis being the site of synthesis of most of the coagulation factors and natural anticoagulants, as well as fibrinolytic factors except the main activators of the fibrinolytic system (t-PA and u-PA). The liver also clears many of the activated clotting and fibrinolytic factors, as well as haemostatic activation complexes (TAT and PAP) and end product of fibrin degradation, FDP. Therefore, liver disease results in a complex and multifactorial pattern of defects in haemostatic function in the form of: (i) decreased synthesis of coagulation factors (ii) Abnormal protein synthesis e.g. dysfibrinogen (iii) Deficiency of natural anticoagulants (iv) Enhanced fibrinolytic activity (v) Quantitative and qualitative platelet defects (vi) Consumptive coagulopathy as in advanced liver disease. These abnormalities of haemostasis, which often occurs in the form of multiple defects, underlie the haemorrhagic diathesis, which often complicates liver disease. In the same manner, measurement of various haemostatic factors can be employed to reflect the degree of liver damage |
| first_indexed | 2024-12-18T23:57:04Z |
| format | Article |
| id | doaj.art-7e52fdb521894ef4adaea8bcfb317656 |
| institution | Directory Open Access Journal |
| issn | 1319-3767 |
| language | English |
| last_indexed | 2024-12-18T23:57:04Z |
| publishDate | 2003-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Saudi Journal of Gastroenterology |
| spelling | doaj.art-7e52fdb521894ef4adaea8bcfb3176562022-12-21T20:46:39ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37672003-01-01925968The liver and the haemeostatic systemAl Ghumlas AbeerAbdelGader AbdelThe liver plays a central role in the control of haemostasis being the site of synthesis of most of the coagulation factors and natural anticoagulants, as well as fibrinolytic factors except the main activators of the fibrinolytic system (t-PA and u-PA). The liver also clears many of the activated clotting and fibrinolytic factors, as well as haemostatic activation complexes (TAT and PAP) and end product of fibrin degradation, FDP. Therefore, liver disease results in a complex and multifactorial pattern of defects in haemostatic function in the form of: (i) decreased synthesis of coagulation factors (ii) Abnormal protein synthesis e.g. dysfibrinogen (iii) Deficiency of natural anticoagulants (iv) Enhanced fibrinolytic activity (v) Quantitative and qualitative platelet defects (vi) Consumptive coagulopathy as in advanced liver disease. These abnormalities of haemostasis, which often occurs in the form of multiple defects, underlie the haemorrhagic diathesis, which often complicates liver disease. In the same manner, measurement of various haemostatic factors can be employed to reflect the degree of liver damagehttp://www.saudijgastro.com/article.asp?issn=1319-3767;year=2003;volume=9;issue=2;spage=59;epage=68;aulast=Alliver disease. haemostasiscoagulationfibrinolysisnatural anticoagulantantithrombin IIIprotein C. protein S and platelets |
| spellingShingle | Al Ghumlas Abeer AbdelGader Abdel The liver and the haemeostatic system The Saudi Journal of Gastroenterology liver disease. haemostasis coagulation fibrinolysis natural anticoagulant antithrombin III protein C. protein S and platelets |
| title | The liver and the haemeostatic system |
| title_full | The liver and the haemeostatic system |
| title_fullStr | The liver and the haemeostatic system |
| title_full_unstemmed | The liver and the haemeostatic system |
| title_short | The liver and the haemeostatic system |
| title_sort | liver and the haemeostatic system |
| topic | liver disease. haemostasis coagulation fibrinolysis natural anticoagulant antithrombin III protein C. protein S and platelets |
| url | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2003;volume=9;issue=2;spage=59;epage=68;aulast=Al |
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