A scoping review of physiological biomarkers in autism
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by pervasive deficits in social interaction, communication impairments, and the presence of restricted and repetitive behaviors. This complex disorder is a significant public health concern due to its escalating incidence...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1269880/full |
| _version_ | 1797690643282132992 |
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| author | Jiatong Shan Jiatong Shan Yunhao Gu Jie Zhang Xiaoqing Hu Xiaoqing Hu Haiyan Wu Tifei Yuan Di Zhao |
| author_facet | Jiatong Shan Jiatong Shan Yunhao Gu Jie Zhang Xiaoqing Hu Xiaoqing Hu Haiyan Wu Tifei Yuan Di Zhao |
| author_sort | Jiatong Shan |
| collection | DOAJ |
| description | Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by pervasive deficits in social interaction, communication impairments, and the presence of restricted and repetitive behaviors. This complex disorder is a significant public health concern due to its escalating incidence and detrimental impact on quality of life. Currently, extensive investigations are underway to identify prospective susceptibility or predictive biomarkers, employing a physiological biomarker-based framework. However, knowledge regarding physiological biomarkers in relation to Autism is sparse. We performed a scoping review to explore putative changes in physiological activities associated with behaviors in individuals with Autism. We identified studies published between January 2000 and June 2023 from online databases, and searched keywords included electroencephalography (EEG), magnetoencephalography (MEG), electrodermal activity markers (EDA), eye-tracking markers. We specifically detected social-related symptoms such as impaired social communication in ASD patients. Our results indicated that the EEG/ERP N170 signal has undergone the most rigorous testing as a potential biomarker, showing promise in identifying subgroups within ASD and displaying potential as an indicator of treatment response. By gathering current data from various physiological biomarkers, we can obtain a comprehensive understanding of the physiological profiles of individuals with ASD, offering potential for subgrouping and targeted intervention strategies. |
| first_indexed | 2024-03-12T02:03:18Z |
| format | Article |
| id | doaj.art-7e540b0018c24adc9dfdbe76528f16e3 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-12T02:03:18Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-7e540b0018c24adc9dfdbe76528f16e32023-09-07T09:36:58ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-09-011710.3389/fnins.2023.12698801269880A scoping review of physiological biomarkers in autismJiatong Shan0Jiatong Shan1Yunhao Gu2Jie Zhang3Xiaoqing Hu4Xiaoqing Hu5Haiyan Wu6Tifei Yuan7Di Zhao8Shanghai Key Laboratory of Psychotic Disorders, Brain Health Institute, National Center for Mental Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Arts and Sciences, New York University Shanghai, Shanghai, ChinaGraduate School of Education, University of Pennsylvania, Philadelphia, PA, United StatesDepartment of Neurology, Institute of Neurology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Psychology, The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaHKU, Shenzhen Institute of Research and Innovation, Shenzhen, ChinaCenter for Cognitive and Brain Sciences and Department of Psychology, Macau, ChinaShanghai Key Laboratory of Psychotic Disorders, Brain Health Institute, National Center for Mental Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Psychotic Disorders, Brain Health Institute, National Center for Mental Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaAutism spectrum disorder (ASD) is a neurodevelopmental condition characterized by pervasive deficits in social interaction, communication impairments, and the presence of restricted and repetitive behaviors. This complex disorder is a significant public health concern due to its escalating incidence and detrimental impact on quality of life. Currently, extensive investigations are underway to identify prospective susceptibility or predictive biomarkers, employing a physiological biomarker-based framework. However, knowledge regarding physiological biomarkers in relation to Autism is sparse. We performed a scoping review to explore putative changes in physiological activities associated with behaviors in individuals with Autism. We identified studies published between January 2000 and June 2023 from online databases, and searched keywords included electroencephalography (EEG), magnetoencephalography (MEG), electrodermal activity markers (EDA), eye-tracking markers. We specifically detected social-related symptoms such as impaired social communication in ASD patients. Our results indicated that the EEG/ERP N170 signal has undergone the most rigorous testing as a potential biomarker, showing promise in identifying subgroups within ASD and displaying potential as an indicator of treatment response. By gathering current data from various physiological biomarkers, we can obtain a comprehensive understanding of the physiological profiles of individuals with ASD, offering potential for subgrouping and targeted intervention strategies.https://www.frontiersin.org/articles/10.3389/fnins.2023.1269880/fullautism spectrum disorderphysiological biomarkerselectroencephalographymagnetoencephalographyelectrodermal activity markerseye-tracking markers |
| spellingShingle | Jiatong Shan Jiatong Shan Yunhao Gu Jie Zhang Xiaoqing Hu Xiaoqing Hu Haiyan Wu Tifei Yuan Di Zhao A scoping review of physiological biomarkers in autism Frontiers in Neuroscience autism spectrum disorder physiological biomarkers electroencephalography magnetoencephalography electrodermal activity markers eye-tracking markers |
| title | A scoping review of physiological biomarkers in autism |
| title_full | A scoping review of physiological biomarkers in autism |
| title_fullStr | A scoping review of physiological biomarkers in autism |
| title_full_unstemmed | A scoping review of physiological biomarkers in autism |
| title_short | A scoping review of physiological biomarkers in autism |
| title_sort | scoping review of physiological biomarkers in autism |
| topic | autism spectrum disorder physiological biomarkers electroencephalography magnetoencephalography electrodermal activity markers eye-tracking markers |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1269880/full |
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