Theory of mind profile and cerebellar alterations in remitted bipolar disorder 1 and 2: a comparison study
The literature on social cognition abilities in bipolar disorder (BD) is controversial about the occurrence of theory of mind (ToM) alterations. In addition to other cerebral structures, such as the frontal and limbic areas, the processing of socially relevant stimuli has also been attributed to the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Behavioral Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnbeh.2022.971244/full |
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| author | Giusy Olivito Giusy Olivito Michela Lupo Libera Siciliano Libera Siciliano Andrea Gragnani Andrea Gragnani Marco Saettoni Marco Saettoni Corinna Pancheri Matteo Panfili Fabiana Pignatelli Roberto Delle Chiaie Maria Leggio Maria Leggio |
| author_facet | Giusy Olivito Giusy Olivito Michela Lupo Libera Siciliano Libera Siciliano Andrea Gragnani Andrea Gragnani Marco Saettoni Marco Saettoni Corinna Pancheri Matteo Panfili Fabiana Pignatelli Roberto Delle Chiaie Maria Leggio Maria Leggio |
| author_sort | Giusy Olivito |
| collection | DOAJ |
| description | The literature on social cognition abilities in bipolar disorder (BD) is controversial about the occurrence of theory of mind (ToM) alterations. In addition to other cerebral structures, such as the frontal and limbic areas, the processing of socially relevant stimuli has also been attributed to the cerebellum, which has been demonstrated to be involved in the above-mentioned disorder. Nevertheless, the cerebellar contribution to ToM deficits in bipolar patients needs to be elucidated further. To this aim, two tests assessing different components of ToM were used to evaluate the ability to appreciate affective and mental states of others in 17 individuals with a diagnosis of BD type 1 (BD1) and 13 with BD type 2 (BD2), both in the euthymic phase, compared to healthy matched controls. Cerebellar gray matter (GM) volumes were extracted and compared between BD1 and controls and BD2 and controls by using voxel-based morphometry. The results showed that BD1 patients were compromised in the cognitive and advanced components of ToM, while the BD2 ToM profile resulted in a more widespread compromise, also involving affective and automatic components. Both overlapping and differing areas of cerebellar GM reduction were found. The two groups of patients presented a pattern of GM reduction in cerebellar portions that are known to be involved in the affective and social domains, such as the vermis and Crus I and Crus II. Interestingly, in both BD1 and BD2, positive correlations were detected between lower ToM scores and decreased volumes in the cerebellum. Overall, BD2 patients showed a more compromised ToM profile and greater cerebellar impairment than BD1 patients. The different patterns of structural abnormalities may account for the different ToM performances evidenced, thus leading to divergent profiles between BD1 and BD2. |
| first_indexed | 2024-04-12T23:31:33Z |
| format | Article |
| id | doaj.art-7e5456aa494d41a29b1e8a81aab9e89a |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-04-12T23:31:33Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-7e5456aa494d41a29b1e8a81aab9e89a2022-12-22T03:12:16ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532022-09-011610.3389/fnbeh.2022.971244971244Theory of mind profile and cerebellar alterations in remitted bipolar disorder 1 and 2: a comparison studyGiusy Olivito0Giusy Olivito1Michela Lupo2Libera Siciliano3Libera Siciliano4Andrea Gragnani5Andrea Gragnani6Marco Saettoni7Marco Saettoni8Corinna Pancheri9Matteo Panfili10Fabiana Pignatelli11Roberto Delle Chiaie12Maria Leggio13Maria Leggio14Ataxia Laboratory, Fondazione Santa Lucia IRCCS, Rome, ItalyDepartment of Psychology, Sapienza University of Rome, Rome, ItalyServizio di Tutela della Salute Mentale e Riabilitazione dell’Età Evolutiva ASL, Rome, ItalyAtaxia Laboratory, Fondazione Santa Lucia IRCCS, Rome, ItalyDepartment of Psychology, Sapienza University of Rome, Rome, ItalyScuola di Psicoterapia Cognitiva (SPC), Grosseto, ItalyAssociazione Psicologia Cognitiva (APC)/Scuola di Psicoterapia Cognitiva (SPC), Rome, ItalyScuola di Psicoterapia Cognitiva (SPC), Grosseto, ItalyUnità Funzionale Salute Mentale Adulti ASL Toscana Nord-Ovest Valle del Serchio, Pisa, ItalyDepartment of Neuroscience and Mental Health–Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, ItalyDepartment of Neuroscience and Mental Health–Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, ItalyDepartment of Psychology, Sapienza University of Rome, Rome, ItalyDepartment of Neuroscience and Mental Health–Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, ItalyAtaxia Laboratory, Fondazione Santa Lucia IRCCS, Rome, ItalyDepartment of Psychology, Sapienza University of Rome, Rome, ItalyThe literature on social cognition abilities in bipolar disorder (BD) is controversial about the occurrence of theory of mind (ToM) alterations. In addition to other cerebral structures, such as the frontal and limbic areas, the processing of socially relevant stimuli has also been attributed to the cerebellum, which has been demonstrated to be involved in the above-mentioned disorder. Nevertheless, the cerebellar contribution to ToM deficits in bipolar patients needs to be elucidated further. To this aim, two tests assessing different components of ToM were used to evaluate the ability to appreciate affective and mental states of others in 17 individuals with a diagnosis of BD type 1 (BD1) and 13 with BD type 2 (BD2), both in the euthymic phase, compared to healthy matched controls. Cerebellar gray matter (GM) volumes were extracted and compared between BD1 and controls and BD2 and controls by using voxel-based morphometry. The results showed that BD1 patients were compromised in the cognitive and advanced components of ToM, while the BD2 ToM profile resulted in a more widespread compromise, also involving affective and automatic components. Both overlapping and differing areas of cerebellar GM reduction were found. The two groups of patients presented a pattern of GM reduction in cerebellar portions that are known to be involved in the affective and social domains, such as the vermis and Crus I and Crus II. Interestingly, in both BD1 and BD2, positive correlations were detected between lower ToM scores and decreased volumes in the cerebellum. Overall, BD2 patients showed a more compromised ToM profile and greater cerebellar impairment than BD1 patients. The different patterns of structural abnormalities may account for the different ToM performances evidenced, thus leading to divergent profiles between BD1 and BD2.https://www.frontiersin.org/articles/10.3389/fnbeh.2022.971244/fullsocial cognitionmentalizingemotionvoxel-based morphometrygray matter |
| spellingShingle | Giusy Olivito Giusy Olivito Michela Lupo Libera Siciliano Libera Siciliano Andrea Gragnani Andrea Gragnani Marco Saettoni Marco Saettoni Corinna Pancheri Matteo Panfili Fabiana Pignatelli Roberto Delle Chiaie Maria Leggio Maria Leggio Theory of mind profile and cerebellar alterations in remitted bipolar disorder 1 and 2: a comparison study Frontiers in Behavioral Neuroscience social cognition mentalizing emotion voxel-based morphometry gray matter |
| title | Theory of mind profile and cerebellar alterations in remitted bipolar disorder 1 and 2: a comparison study |
| title_full | Theory of mind profile and cerebellar alterations in remitted bipolar disorder 1 and 2: a comparison study |
| title_fullStr | Theory of mind profile and cerebellar alterations in remitted bipolar disorder 1 and 2: a comparison study |
| title_full_unstemmed | Theory of mind profile and cerebellar alterations in remitted bipolar disorder 1 and 2: a comparison study |
| title_short | Theory of mind profile and cerebellar alterations in remitted bipolar disorder 1 and 2: a comparison study |
| title_sort | theory of mind profile and cerebellar alterations in remitted bipolar disorder 1 and 2 a comparison study |
| topic | social cognition mentalizing emotion voxel-based morphometry gray matter |
| url | https://www.frontiersin.org/articles/10.3389/fnbeh.2022.971244/full |
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