Trim21 depletion alleviates bone loss in osteoporosis via activation of YAP1/β-catenin signaling

Trim21 depletion alleviates bone loss in osteoporosis via activation of YAP1/β-catenin signaling

Abstract Despite the diverse roles of tripartite motif (Trim)-containing proteins in the regulation of autophagy, the innate immune response, and cell differentiation, their roles in skeletal diseases are largely unknown. We recently demonstrated that Trim21 plays a crucial role in regulating osteob...

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Bibliographic Details
Main Authors: Ri-Xu Liu, Rong-He Gu, Zhi-Peng Li, Zhi-Quan Hao, Qin-Xiao Hu, Zhen-Yan Li, Xiao-Gang Wang, Wang Tang, Xiao-He Wang, Yu-Kai Zeng, Zhen-Wei Li, Qiu Dong, Xiao-Feng Zhu, Di Chen, Ke-Wei Zhao, Rong-Hua Zhang, Zhen-Gang Zha, Huan-Tian Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2023-10-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-023-00296-3

Internet

https://doi.org/10.1038/s41413-023-00296-3

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