Association of androgen receptor expression with glucose metabolic features in triple-negative breast cancer
<h4>Background</h4> Androgen receptor (AR) is a potential therapeutic target in triple-negative breast cancer (TNBC). We aimed to elucidate the association of AR expression with glucose metabolic features in TNBC. <h4>Methods</h4> Two independent datasets were analyzed: FDG P...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524647/?tool=EBI |
| _version_ | 1811229937659543552 |
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| author | Reeree Lee Han-Byoel Lee Jin Chul Paeng Hongyoon Choi Wonseok Whi Wonshik Han Ju Won Seok Keon Wook Kang Gi Jeong Cheon |
| author_facet | Reeree Lee Han-Byoel Lee Jin Chul Paeng Hongyoon Choi Wonseok Whi Wonshik Han Ju Won Seok Keon Wook Kang Gi Jeong Cheon |
| author_sort | Reeree Lee |
| collection | DOAJ |
| description | <h4>Background</h4> Androgen receptor (AR) is a potential therapeutic target in triple-negative breast cancer (TNBC). We aimed to elucidate the association of AR expression with glucose metabolic features in TNBC. <h4>Methods</h4> Two independent datasets were analyzed: FDG PET data of our institution and a public dataset of GSE135565. In PET analysis, patients with TNBC who underwent pretreatment PET between Jan 2013 and Dec 2017 were retrospectively enrolled. Clinicopathologic features and maximum standardized uptake value (SUVmax) of tumors were compared with AR expression. In GSE135565 dataset, glycolysis score was calculated by the pattern of glycolysis-related genes, and of which association with SUVmax and AR gene expression were analyzed. <h4>Results</h4> A total of 608 female patients were included in the PET data of our institution. SUVmax was lower in AR-positive tumors (P < 0.001) and correlated with lower AR expression (rho = –0.26, P < 0.001). In multivariate analysis, AR was a deterministic factor for low SUVmax (P = 0.012), along with other key clinicopathologic features. In the GSE135565 dataset, AR expression also exhibited a negative correlation with SUVmax (r = –0.34, P = 0.001) and the glycolysis score (r = –0.27, P = 0.013). <h4>Conclusions</h4> Low glucose metabolism is a signature of AR expression in TNBC. It is suggested that evaluation of AR expression status needs to be considered in clinical practice particularly in TNBC with low glucose metabolism. |
| first_indexed | 2024-04-12T10:21:33Z |
| format | Article |
| id | doaj.art-7e561aa21fe34636a400b40c718adb0c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T10:21:33Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7e561aa21fe34636a400b40c718adb0c2022-12-22T03:37:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01179Association of androgen receptor expression with glucose metabolic features in triple-negative breast cancerReeree LeeHan-Byoel LeeJin Chul PaengHongyoon ChoiWonseok WhiWonshik HanJu Won SeokKeon Wook KangGi Jeong Cheon<h4>Background</h4> Androgen receptor (AR) is a potential therapeutic target in triple-negative breast cancer (TNBC). We aimed to elucidate the association of AR expression with glucose metabolic features in TNBC. <h4>Methods</h4> Two independent datasets were analyzed: FDG PET data of our institution and a public dataset of GSE135565. In PET analysis, patients with TNBC who underwent pretreatment PET between Jan 2013 and Dec 2017 were retrospectively enrolled. Clinicopathologic features and maximum standardized uptake value (SUVmax) of tumors were compared with AR expression. In GSE135565 dataset, glycolysis score was calculated by the pattern of glycolysis-related genes, and of which association with SUVmax and AR gene expression were analyzed. <h4>Results</h4> A total of 608 female patients were included in the PET data of our institution. SUVmax was lower in AR-positive tumors (P < 0.001) and correlated with lower AR expression (rho = –0.26, P < 0.001). In multivariate analysis, AR was a deterministic factor for low SUVmax (P = 0.012), along with other key clinicopathologic features. In the GSE135565 dataset, AR expression also exhibited a negative correlation with SUVmax (r = –0.34, P = 0.001) and the glycolysis score (r = –0.27, P = 0.013). <h4>Conclusions</h4> Low glucose metabolism is a signature of AR expression in TNBC. It is suggested that evaluation of AR expression status needs to be considered in clinical practice particularly in TNBC with low glucose metabolism.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524647/?tool=EBI |
| spellingShingle | Reeree Lee Han-Byoel Lee Jin Chul Paeng Hongyoon Choi Wonseok Whi Wonshik Han Ju Won Seok Keon Wook Kang Gi Jeong Cheon Association of androgen receptor expression with glucose metabolic features in triple-negative breast cancer PLoS ONE |
| title | Association of androgen receptor expression with glucose metabolic features in triple-negative breast cancer |
| title_full | Association of androgen receptor expression with glucose metabolic features in triple-negative breast cancer |
| title_fullStr | Association of androgen receptor expression with glucose metabolic features in triple-negative breast cancer |
| title_full_unstemmed | Association of androgen receptor expression with glucose metabolic features in triple-negative breast cancer |
| title_short | Association of androgen receptor expression with glucose metabolic features in triple-negative breast cancer |
| title_sort | association of androgen receptor expression with glucose metabolic features in triple negative breast cancer |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524647/?tool=EBI |
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